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  • 垫状卷柏三酚

    Selaginellin

    垫状卷柏三酚
    产品编号 CFN95030
    CAS编号 941269-84-7
    分子式 = 分子量 C34H24O5 = 512.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Selaginella pulvinata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    垫状卷柏三酚 CFN95030 941269-84-7 1mg QQ客服:1413575084
    垫状卷柏三酚 CFN95030 941269-84-7 5mg QQ客服:1413575084
    垫状卷柏三酚 CFN95030 941269-84-7 10mg QQ客服:1413575084
    垫状卷柏三酚 CFN95030 941269-84-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Leipzig (Germany)
  • University of Illinois at Chicago (USA)
  • National Cancer Center Research Institute (Japan)
  • National Research Council of Canada (Canada)
  • FORTH-IMBB (Greece)
  • University of Stirling (United Kingdom)
  • Osmania University (India)
  • Universiti Malaysia Pahang (Malaysia)
  • Chungnam National University (Korea)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Universidade Católica Portuguesa (Portugal)
  • University of Medicine and Pharmacy (Romania)
  • University of South Australia (Australia)
  • Melbourne University (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Agriculture2022, 12(2),227.
  • Pharmacol Rep.2020, 72(2):472-480.
  • Phytother Res.2022, 35844057.
  • Planta Med.2018, 84(15):1101-1109
  • J Appl Biol Chem2021, 64(3):245-251.
  • Exp Neurobiol.2018, 27(3):200-209
  • BMC Complement Altern Med.2014, 14:352
  • J Food Compos Anal2017, 62:197-204
  • J Cosmet Dermatol.2022, 21(1):396-402.
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • Journal of Apiculture2019, 34(2):131-136
  • GENENCELL2023, 25:4356740
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Cytotechnology2022, s10616
  • Nutrients.2022, 14(19):4170.
  • Mol Med Rep.2022, 26(4):299.
  • South African J of Botany2020, 135:50-57
  • J. Soc. Cosmet. Sci. Korea2021, 47(1):57-63
  • Pharmacol Rep.2022, 74(1):175-188.
  • Oncol Rep.2019, 41(4):2453-2463
  • Fitoterapia.2018, 124:92-102
  • J. Traditional Thai Medical Res. 2022,8(1):1-14.
  • Biomed Pharmacother.2021, 137:111362.
  • ...
  • 生物活性
    Description: Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression of klotho gene. Selaginellin shows inhibitory effect on high glucose-induced cell injury and apoptosis in differentiated PC12 cells, which is related to inhibition of LOX-1/NADPH oxidase-reactive oxygen species/caspase-3 signaling pathway.
    Targets: Caspase | ROS | NADPH-oxidase | LOX
    In vitro:
    Naunyn Schmiedebergs Arch Pharmacol. 2010 Jan;381(1):73-81.
    Protective effect of selaginellin on glutamate-induced cytotoxicity and apoptosis in differentiated PC12 cells.[Pubmed: 19936711 ]
    L-glutamate plays a key role in neuronal cell death associated with many neurodegenerative conditions such as cerebral ischemia, hypoxia, Alzheimer's, Huntington's, and Parkinson's diseases.
    METHODS AND RESULTS:
    Selaginellin, a component extracted from Saussurea pulvinata (Hook.et Grev.) Maximo, was assessed for its ability to protect rat pheochromocytoma (PC12) cells against oxidative toxicity induced by glutamate. The differentiated PC12 cells were pretreated with various concentrations (10(-7), 3 x 10(-7), or 10(-6) M) of Selaginellin for 1 h prior to exposure to L-glutamate. Selaginellin was shown to protect PC12 cells against glutamate toxicity, as determined by characteristic morphological features, lactate dehydrogenase release and cell viability, and apoptosis as evaluated by Hoechst 33342 staining assay and caspase-3 activity. In addition, the increase in levels of reactive oxygen species and decrease in klotho gene expression induced by glutamate were significantly reversed by Selaginellin.
    CONCLUSIONS:
    Our study suggests that Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression of klotho gene.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9508 mL 9.7542 mL 19.5084 mL 39.0168 mL 48.771 mL
    5 mM 0.3902 mL 1.9508 mL 3.9017 mL 7.8034 mL 9.7542 mL
    10 mM 0.1951 mL 0.9754 mL 1.9508 mL 3.9017 mL 4.8771 mL
    50 mM 0.039 mL 0.1951 mL 0.3902 mL 0.7803 mL 0.9754 mL
    100 mM 0.0195 mL 0.0975 mL 0.1951 mL 0.3902 mL 0.4877 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    马尿酸; Hippuric acid CFN70124 495-69-2 C9H9NO3 = 179.1 20mg QQ客服:2056216494
    6'-O-反式-肉桂酰 8-表金吉苷酸 ; 6'-O-Cinnamoyl-8-epikingisidic acid CFN96754 1403984-03-1 C25H28O12 = 520.48 5mg QQ客服:1457312923
    23,24-二氢异葫芦素 B; 23,24-dihydroisocucurbitacin B CFN92894 68354-21-2 C32H48O8 = 560.72 5mg QQ客服:1413575084
    Bonducellpin C; Bonducellpin C CFN89369 197781-84-3 C23H32O7 = 420.49 5mg QQ客服:3257982914

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