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  • 开环异落叶松树脂酚

    Secoisolariciresinol

    开环异落叶松树脂酚
    产品编号 CFN98363
    CAS编号 29388-59-8
    分子式 = 分子量 C20H26O6 = 362.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The heartwoods of Podocarpus spicata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    开环异落叶松树脂酚 CFN98363 29388-59-8 1mg QQ客服:2056216494
    开环异落叶松树脂酚 CFN98363 29388-59-8 5mg QQ客服:2056216494
    开环异落叶松树脂酚 CFN98363 29388-59-8 10mg QQ客服:2056216494
    开环异落叶松树脂酚 CFN98363 29388-59-8 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of British Columbia (Canada)
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  • University of Malaya (Malaysia)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Ain Shams University (Egypt)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Sci Food Agric.2017, 97(5):1656-1662
  • JAOCS2021, 98(7):779-794.
  • Pol J Microbiol.2021, 70(1):117-130.
  • Viruses.2021, 13(11):2118.
  • Ind Crops Prod.2015, 67:185-191
  • Antioxidants (Basel).2020, 9(2): E119
  • Molecules.2021, 26(16):4722.
  • Pharmaceutics2022, 14(2),376.
  • Sci Rep.2023, 13(1):21690.
  • J Agric Food Chem.2020, 68(51):15164-15175
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • Nutrients.2022, 14(16):3393.
  • Revista Brasileira de Farmacognosia2021, 31:794-804.
  • BMB Rep.2018, 51(5):249-254
  • Foods.2020, 9(10):1348.
  • Ulm University Medical Center2020, doi: 10.18725.
  • Chem Biol Interact.2022, 368:110248.
  • Food Chem.2023, 404(Pt A):134517.
  • J Cell Mol Med.2021, 25(5):2645-2654.
  • Int J Mol Med.2015, 35(5):1237-45
  • Nutrients.2022, 14(19):4170.
  • Journal of Food Hygiene and Safety2019, 34(5):413-420
  • Journal of Plant Growth Regulation2022, 10705-2.
  • ...
  • 生物活性
    Description: Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation in 3T3-L1 adipocytes. Secoisolariciresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. (-)-Secoisolariciresinol exerts a suppressive effect on the gain of body weight of mice fed a high-fat diet by inducing gene expression of adiponectin, resulting in the altered expression of various genes related to the synthesis and β-oxidation of fatty acids.
    Targets: IFN-γ | TNF-α | Estrogen receptor | Progestogen receptor
    In vitro:
    Biosci Biotechnol Biochem. 2009 Jan;73(1):35-9.
    The Effect of Secoisolariciresinol on 3T3-L1 Adipocytes and the Relationship between Molecular Structure and Activity.[Pubmed: 19129664 ]
    As we have reported, flaxseed lignan, (+)-Secoisolariciresinol (SECO), (-)-SECO, and meso-SECO were stereoselectively synthesized and their biological functions were evaluated.
    METHODS AND RESULTS:
    In the present study, we focused on the effects of SECOs on the regulation of 3T3-L1 adipocytes, and identified the structure-activity relationships. Optically active SECO and meso-SECO were tested for their effects on lipid metabolism in 3T3-L1 adipocytes. (-)-SECO accelerated adiponectin production of 3T3-L1 adipocytes. On the other hand, (+)- and meso-SECO suppressed the production of adiponectin. In addition, triglyceride (TG) accumulation in 3T3-L1 adipocytes was significantly suppressed by all three SECOs tested here, as was 17beta-estradiol, when the SECOs were added to the medium during induction of 3T3-L1 preadipocytes to adipocytes. Especially, (-)-SECO strongly reduced TG accumulation.
    CONCLUSIONS:
    It is well-known that SECO has estrogen-like activity. Hence the estrogen-like activity of each SECO compound was assessed. Only (-)-SECO had estrogen-like activity.
    Int J Angiol. 2000 Oct;9(4):220-225.
    Antioxidant Activity of Secoisolariciresinol Diglucoside-derived Metabolites, Secoisolariciresinol, Enterodiol, and Enterolactone.[Pubmed: 11062311]

    METHODS AND RESULTS:
    Secoisolariciresinol diglucoside (SDG), an antioxidant isolated from flaxseed, is metabolized to Secoisolariciresinol (SECO), enterodiol (ED), and enterolactone (EL) in the body. The effectiveness of SDG in hypercholesterolemic atherosclerosis, diabetes, and endotoxic shock could be due to these metabolites. These metabolites may have antioxidant activity. However, the antioxidant activity of these metabolites is not known. The antioxidant activity of SECO, ED, and EL was investigated using chemiluminescence (CL) of zymosan-activated polymorphonuclear leukocytes (PMNLs) [PMNL-CL]. Other antioxidants (SDG and vitamin E) were also used for comparison. SDG, SECO, ED, EL, and vitamin E, each in the concentration of 0.5, 1.0, 2.5, 5.0 and 10.0 mg/ml, produced a concentration-dependent reduction in zymosan-activated PMNL-CL. SDG, SECO, ED, EL, and vitamin E, in the concentration of 2.5 mg/ml, produced a reduction of zymosan-activated PMNL-CL by 23.8%, 91.2%, 94.2%, 81.6% and 18.7%, respectively. Activated PMNLs produce reactive oxygen species and luminol-dependent CL reflects the amount of oxygen species generated from activated PMNLs. The reduction of PMNL-CL, therefore, reflects the antioxidant activity of the compounds studied.
    CONCLUSIONS:
    These results suggest that the metabolites of SDG have antioxidant activity. The antioxidant activity was highest with SECO and ED and lowest with vitamin E. The antioxidant potency of SECO, ED, EL, and SDG was 4.86, 5.02, 4.35, and 1.27 respectively, as compared to vitamin E. SECO, ED and EL are respectively 3.82, 3.95, and 3.43 more potent than SDG.
    In vivo:
    Food Funct. 2014 Mar;5(3):491-501.
    Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humans.[Pubmed: 24429845]
    Secoisolariciresinol-diglycoside (SDG), a natural dietary lignan of flaxseeds now available in dietary supplements, is converted by intestinal bacteria to the mammalian lignans enterodiol and enterolactone.
    METHODS AND RESULTS:
    Our objective was to determine the bioavailability and pharmacokinetics of Secoisolariciresinol-diglycoside in purified flaxseed extracts under dose-ranging and steady-state conditions, and to examine whether differences in Secoisolariciresinol-diglycoside purity influence bioavailability. Pharmacokinetic studies were performed on healthy postmenopausal women after oral intake of 25, 50, 75, 86 and 172 mg of Secoisolariciresinol-diglycoside. Extracts differing in Secoisolariciresinol-diglycoside purity were compared, and steady-state lignan concentrations measured after daily intake for one week. Blood and urine samples were collected at timed intervals and Secoisolariciresinol, enterodiol and enterolactone concentrations measured by mass spectrometry. Secoisolariciresinol-diglycoside was efficiently hydrolyzed and converted to Secoisolariciresinol.
    CONCLUSIONS:
    This study defines the pharmacokinetics of Secoisolariciresinol-diglycoside and shows it is first hydrolyzed and then metabolized in a time-dependent sequence to Secoisolariciresinol, enterodiol and ultimately enterolactone, and these metabolites are efficiently absorbed.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7594 mL 13.7969 mL 27.5938 mL 55.1876 mL 68.9845 mL
    5 mM 0.5519 mL 2.7594 mL 5.5188 mL 11.0375 mL 13.7969 mL
    10 mM 0.2759 mL 1.3797 mL 2.7594 mL 5.5188 mL 6.8985 mL
    50 mM 0.0552 mL 0.2759 mL 0.5519 mL 1.1038 mL 1.3797 mL
    100 mM 0.0276 mL 0.138 mL 0.2759 mL 0.5519 mL 0.6898 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (E)-(1,3-苯并二恶茂-5-甲基)(1,3-苯并二恶茂-5-亚甲基) 丁二酸二甲酯; Dehydroheliobuphthalmin CFN99046 103001-05-4 C22H20O8 = 412.4 5mg QQ客服:2056216494
    二氢愈创木脂酸; Dihydroguaiaretic acid CFN97133 66322-34-7 C20H26O4 = 330.4 10mg QQ客服:2159513211
    安五脂素; Anwulignan CFN98539 107534-93-0 C20H24O4 = 328.41 20mg QQ客服:3257982914
    赤式-6-澳白木脂素; erythro-Austrobailignan-6 CFN95501 114127-24-1 C20H24O4 = 328.4 10mg QQ客服:3257982914
    Schineolignin B; Schineolignin B CFN92717 1352185-26-2 C22H30O5 = 374.5 5mg QQ客服:2159513211
    华中五脂素; Sphenanlignan CFN95245 866347-36-6 C21H26O5 = 358.4 5mg QQ客服:1457312923
    Arisanschinin E; Arisanschinin E CFN95221 1333378-33-8 C21H28O5 = 360.5 5mg QQ客服:1413575084
    前五味子脂素; Pregomisin CFN96694 66280-26-0 C22H30O6 = 390.47 10mg QQ客服:215959384
    脱水开环异落叶松树脂酚; Anhydrosecoisolariciresinol CFN89236 29388-33-8 C20H24O5 = 344.40 5mg QQ客服:2056216494
    4,4'-[[(2S,3S,4S)-四氢-2-甲氧基-3,4-呋喃二基]二(亚甲基)]二[2-甲氧基苯酚]; 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan CFN96711 1206464-65-4 C21H26O6 = 374.43 5mg QQ客服:215959384

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