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    异东莨菪醇

    Scopoline

    异东莨菪醇
    产品编号 CFN00228
    CAS编号 487-27-4
    分子式 = 分子量 C8H13NO2 = 155.20
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Alkaloids
    植物来源 The herbs of Atropa belladonna.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异东莨菪醇 CFN00228 487-27-4 1mg QQ客服:1413575084
    异东莨菪醇 CFN00228 487-27-4 5mg QQ客服:1413575084
    异东莨菪醇 CFN00228 487-27-4 10mg QQ客服:1413575084
    异东莨菪醇 CFN00228 487-27-4 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Nanjing University of Chinese Medicine (China)
  • Auburn University (USA)
  • Agricultural Research Organization (ARO) (Israel)
  • Mahatma Gandhi University (India)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Aveiro University (Portugal)
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  • Universidad de La Salle (Mexico)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Anal Bioanal Chem. 2016, 408(15)
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Front Pharmacol.2017, 8:205
  • Anal Chim Acta.2018, 1039:162-171
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • Mol Cells.2018, 41(8):771-780
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Int J Mol Sci.2019, 21(1):E265
  • J Med Food.2019, 22(10):1067-1077
  • J Pharmaceut Biomed2020, 182:113110
  • J Ethnopharmacol.2020, 249:112381
  • Appl. Sci.2020, 10(20), 7323.
  • Agronomy2020, 10(3),388.
  • Front Microbiol.2020, 11:583594.
  • Pharmaceutics.2020, 12(9):882.
  • Evid Based Complement Alternat Med.2020, 2020:9416962.
  • Molecules.2020, 25(20):4851.
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • Food Chem. 2020, 320:126530
  • J Nat Med.2020, 74(3):550-560.
  • Processes2020, 8(12),1540.
  • ...
  • 生物活性
    Description: Scopoline, tropinol, ecgonine, and granatoline derivatives are therapeutic agents of the pyrrole and pyridine group. Scopoline has fungitoxic effects, it is inhibitory to Sclerotinia at similar doses to scopoletin; as scopolin is known to be less phytotoxic than ayapin and scopoletin, its accumulation may well confer head rot resistance with minimal plant damage and might be one of the bases for resistance to Sclerotinia.
    Targets: Antifection
    In vitro:
    Euphytica, 2006, 147(3):451-60.
    Fungitoxic effect of scopolin and related coumarins on Sclerotinia sclerotiorum. A way to overcome sunflower head rot[Reference: WebLink]

    METHODS AND RESULTS:
    The content of coumarins, as probable phytoalexins, was analysed in four sunflower genotypes that ranged in responses to head rot from highly susceptible to highly resistant. Low levels of all coumarins (scopolin, scopoletin and ayapin) were detected in the three most susceptible genotypes irrespective of time after inoculation. However, in the resistant genotype there was a clear time-dependent disease-induced increase of all coumarins that reached a maximum after 10-14 days. Detailed comparison of the most susceptible and the resistant genotype showed that in the resistant but not the susceptible, scopoletin peroxidase activity increased during the course of the experiment.
    CONCLUSIONS:
    Results confirmed a clear negative correlation between coumarin content and disease symptoms and in particular for scopolin(Scopoline). Furthermore we show for the first time that scopolin(Scopoline) is inhibitory to Sclerotinia at similar doses to scopoletin. As scopolin(Scopoline) is known to be less phytotoxic than ayapin and scopoletin, its accumulation may well confer head rot resistance with minimal plant damage and might be one of the bases for resistance to Sclerotinia.
    Bulletin of the Torrey Botanical Club, 1970, 97(1):22-33.
    Effects of Scopoletin on Growth, CO2 Exchange Rates, and Concentration of Scopoletin, Scopolin, and Chlorogenic Acids in Tobacco, Sunflower, and Pigweed.[Reference: WebLink]
    In an attempt to establish the effects of scopoletin on growth of tobacco, sunflower, and pigweed, seedlings were treated with scopoletin through a nutrient culture.
    METHODS AND RESULTS:
    A threshold level of inhibition was found in all cases between 10-4M and 10-3M concentrations of scopoletin with the former showing no major growth effects, whereas the 10-3M solutions were greatly inhibitory to all three species. All 5 x 10-4M treatments had an intermediate effect on growth. Analyses of scopoletin, scopolin(Scopoline), and chlorogenic acid concentrations of tobacco and sunflower treated with 10-4M and 5 x 10-4M scopoletin concentrations showed that at both of these levels, scopoletin and scopolin(Scopoline) increased significantly in the tissue when compared with the control. The plants treated with the 5 x 10-4M solution had the largest increase in these compounds. The great increase in scopolin(Scopoline) suggested a direct conversion of scopoletin to its glycoside, scopolin(Scopoline), within the plant. Chlorogenic acid levels were not different from controls and the variations in isomers (band 510 and neochlorogenic acid) were indefinite. A reduced shoot:root ratio coincided with a greater build up of scopoletin and scopolin(Scopoline) in the shoots than in the roots of inhibited tobacco seedlings. Respiration rates in treated plants remained unchanged, but CO2 exchange analyses indicated that a reduced net photosynthetic rate was a contributing factor to reduced growth. Net photosynthesis in 10-3M scopoletin treated tobacco plants was depressed to as low as 34% of that of the controls by the fourth day after treatment. In sunflowers, which normally have very small amounts of scopoletin and scopolin(Scopoline) in the tissue, growth retardation was not as pronounced and the lowest photosynthetic rate resulting from treatment was 74% of controls. Reduced growth in leaf area over a 12 day experiment correlated well with the significant reduction in the rate of net photosynthesis in tobacco and a fairly good correlation was found also in sunflower. Amounts of CO2 fixed/illumination hour in treated plants compared with controls reinforced the conclusion that a reduction in net photosynthesis contributed to plant inhibition in tobacco and sunflower plants.
    CONCLUSIONS:
    Limited experiments with pigweed also indicated significantly reduced photosynthesis in the 10-3M scopoletin treated seedlings. Scopoletin could contribute to a cooperative effect causing plant inhibition in the natural environment and therefore be a factor of ecological significance.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.4433 mL 32.2165 mL 64.433 mL 128.866 mL 161.0825 mL
    5 mM 1.2887 mL 6.4433 mL 12.8866 mL 25.7732 mL 32.2165 mL
    10 mM 0.6443 mL 3.2216 mL 6.4433 mL 12.8866 mL 16.1082 mL
    50 mM 0.1289 mL 0.6443 mL 1.2887 mL 2.5773 mL 3.2216 mL
    100 mM 0.0644 mL 0.3222 mL 0.6443 mL 1.2887 mL 1.6108 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Benzoyltropein; Benzoyltropein CFN00212 19145-60-9 C15H19NO2 = 245.32 5mg QQ客服:2056216494
    辣根碱; Cochlearine CFN00213 52418-07-2 C15H19NO3 = 261.32 5mg QQ客服:3257982914
    Tropanyl 3-hydroxy-4-methoxycinnamate; Tropanyl 3-hydroxy-4-methoxycinnamate CFN00216 86702-58-1 C18H23NO4 = 317.38 5mg QQ客服:2159513211
    妥帕可卡因; Tropacocaine CFN00219 537-26-8 C15H19NO2 = 245.32 5mg QQ客服:1457312923
    东莨菪碱; Atroscine CFN00227 138-12-5 C17H21NO4 = 303.36 5mg QQ客服:2932563308
    异东莨菪醇; Scopoline CFN00228 487-27-4 C8H13NO2 = 155.20 5mg QQ客服:2159513211
    惕各酰托品因; Tigloyltropeine CFN00230 495-83-0 C13H21NO2 = 223.31 5mg QQ客服:1457312923
    托品林; Tigloidine CFN00231 533-08-4 C13H21NO2 = 223.31 5mg QQ客服:2932563308
    天仙子胺; Hyoscyamine CFN00232 101-31-5 C17H23NO3 = 289.37 20mg QQ客服:2159513211
    硫酸天仙子胺水合物; Hyoscyamine sulfate hydrate CFN90713 620-61-1 (C17H23NO3)2.H2SO4 = 694.83 20mg QQ客服:2159513211

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