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  • 五味子酯乙

    Schisantherin B

    五味子酯乙
    产品编号 CFN99924
    CAS编号 58546-55-7
    分子式 = 分子量 C28H34O9 = 514.57
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Lignans
    植物来源 The seeds of Schisandra chinensis (Turcz.) Baill.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    五味子酯乙 CFN99924 58546-55-7 10mg QQ客服:1148253675
    五味子酯乙 CFN99924 58546-55-7 20mg QQ客服:1148253675
    五味子酯乙 CFN99924 58546-55-7 50mg QQ客服:1148253675
    五味子酯乙 CFN99924 58546-55-7 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Auckland (New Zealand)
  • Pennsylvania State University (USA)
  • Sant Gadge Baba Amravati University (India)
  • Biotech R&D Institute (USA)
  • Semmelweis Unicersity (Hungary)
  • Calcutta University (India)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Universite de Lille1 (France)
  • University of Perugia (Italy)
  • University of Bonn (Germany)
  • University of East Anglia (United Kingdom)
  • National Research Council of Canada (Canada)
  • Medical University of South Carolina (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Exp Parasitol.2015, 153:160-4
  • J-STAGE2015, 249-255
  • Acta Agriculturae Scandinavica2015, 381-383
  • Nat Prod Sci.2016, 22(2)
  • Front Pharmacol.2016, 7:460
  • Vojnosanit Pregl2016, 75(00):391-391
  • PLoS One.2017, 12(3):e0173585
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Plant Cell Tiss Org2017, 479-486
  • Arch Toxicol.2017, 91(10):3225-3245
  • Chemistry of Natural Compounds2018, 204–206
  • Life Sci.2018, 209:498-506
  • Sci Adv.2018, 4(10)
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • Microb Pathog.2019, 131:128-134
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Int J Mol Sci.2019, 20(16):E4015
  • Environ Toxicol.2019, 34(12):1354-1362
  • J Funct Foods2019, 54:449-456
  • Genes Genomics.2020, 10.1007
  • Nutrients2020, 12(2):488
  • J Sep Sci.2020, 201901140
  • ...
  • 生物活性
    Description: Schisantherin B may protect against cognitive deficits and neurodegeneration induced by Aβ1-42 in mice by regulating the glutamate transporter type 1 (GLT-1) restoration as well as the capacity of Glycogen synthase kinase3β(GSK3β), it also shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis.
    Targets: P450 (e.g. CYP17) | GSK-3 | Beta Amyloid
    In vivo:
    Phytomedicine. 2014 Apr 15;21(5):766-72.
    Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp.[Pubmed: 24462213]
    We recently reported that Wuzhi tablet (WZ), a preparation of the ethanol extract of Wuweizi (Schisandra sphenanthera), had significant effects on blood concentrations of Tacrolimus (FK506) in renal transplant recipients and rats. The active lignans in WZ are schisandrin A, schisandrin B, schisandrin C, schisandrol A, schisandrol B, schisantherin A, and Schisantherin B. Until now, whether the pharmacokinetics of these lignans in WZ would be affected by FK506 remained unknown.
    METHODS AND RESULTS:
    Therefore, this study aimed to investigate whether and how FK506 affected pharmacokinetics of lignans in WZ in rats and the potential roles of CYP3A and P-gp. After a single oral co-administration of FK506 and WZ, the blood concentration of lignans in WZ was decreased by FK506; furthermore, the AUC of schisantherin A, schisandrin A, schisandrol A and schisandrol B was only 64.5%, 47.2%, 55.1% and 57.4% of that of WZ alone group, respectively. Transport study in Caco-2 cells showed that these lignans were not substrates of P-gp, suggesting decreased blood concentration of lignans by FK506 was not via P-gp pathway. Metabolism study in the human recombinant CYP 3A showed that these lignans had higher affinity to CYP3A than that of FK506, and thus had a stronger CYP3A-mediated metabolism.
    CONCLUSIONS:
    It was concluded that the blood concentrations of these lignans were decreased and their CYP3A-mediated metabolisms were increased in the presence of FK506 since these lignans had higher affinity to CYP3A.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9434 mL 9.7169 mL 19.4337 mL 38.8674 mL 48.5843 mL
    5 mM 0.3887 mL 1.9434 mL 3.8867 mL 7.7735 mL 9.7169 mL
    10 mM 0.1943 mL 0.9717 mL 1.9434 mL 3.8867 mL 4.8584 mL
    50 mM 0.0389 mL 0.1943 mL 0.3887 mL 0.7773 mL 0.9717 mL
    100 mM 0.0194 mL 0.0972 mL 0.1943 mL 0.3887 mL 0.4858 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    鹤庆五味子癸素; Schisanwilsonin I CFN98732 1181216-84-1 C28H34O9 = 514.6 5mg QQ客服:1413575084
    内南五味子酯 C; Interiotherin C CFN92730 460090-65-7 C30H36O10 = 556.6 5mg QQ客服:3257982914
    滇藏五味子素G; Negsehisandrin G CFN90533 1023744-69-5 C28H36O7 = 484.6 5mg QQ客服:2159513211
    五味子酯甲; Schisantherin A CFN99925 58546-56-8 C30H32O9 = 536.56 20mg QQ客服:1413575084
    戈米辛D; Gomisin D CFN90122 60546-10-3 C28H34O10 = 530.56 10mg QQ客服:2932563308
    戈米辛 E; Gomisin E CFN96725 72960-21-5 C28H34O9 = 514.57 5mg QQ客服:2932563308
    戈米辛F; Gomisin F CFN92719 62956-47-2 C28H34O9 = 514.6 5mg QQ客服:1148253675
    戈米辛G; Gomisin G CFN90123 62956-48-3 C30H32O9 = 536.6 10mg QQ客服:3257982914
    戈米辛H; Gomisin H CFN94008 66056-20-0 C23H30O7 = 418.5 10mg QQ客服:1148253675
    巴豆酰戈米辛 H; Tigloylgomisin H CFN96618 66069-55-4 C28H36O8 = 500.59 5mg QQ客服:3257982914

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