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  • 五味子酯甲

    Schisantherin A

    五味子酯甲
    产品编号 CFN99925
    CAS编号 58546-56-8
    分子式 = 分子量 C30H32O9 = 536.56
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Lignans
    植物来源 The seeds of Schisandra chinensis (Turcz.) Baill.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    五味子酯甲 CFN99925 58546-56-8 10mg QQ客服:215959384
    五味子酯甲 CFN99925 58546-56-8 20mg QQ客服:215959384
    五味子酯甲 CFN99925 58546-56-8 50mg QQ客服:215959384
    五味子酯甲 CFN99925 58546-56-8 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Minnesota (USA)
  • Wroclaw Medical University (Poland)
  • University of Helsinki (Finland)
  • Lund University (Sweden)
  • Mahatma Gandhi University (India)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Max-Planck-Insitut (Germany)
  • Shanghai Institute of Organic Chemistry (China)
  • University of East Anglia (United Kingdom)
  • Universidad Veracuzana (Mexico)
  • Pennsylvania State University (USA)
  • University of Parma (Italy)
  • Center for protein Engineering (CIP) (Belgium)
  • Almansora University (Egypt)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J.Food Processing & Preservation2022, jfpp.16666
  • Food Bioscience2023, 56:103311.
  • Molecules.2021, 26(2):313.
  • bioRxiv - Biochemistry2023, 548213.
  • Psychopharmacology (Berl).2020, 10.1007
  • Int J Mol Sci.2020, 21(9):3144.
  • J Biomol Struct Dyn.2022, 1-21.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • University of Stuttgart2021, 11682.
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • J Agric Food Chem.2020, 68(51):15164-15175
  • Advances in Traditional Medicine 2021, 21:779-789.
  • Foods.2021, 10(11):2754.
  • J Hematol Oncol.2018, 11(1):112
  • Food Chem Toxicol.2020, 135:110863
  • Phytother Res.2015, 29(7):1088-96
  • Int J Mol Sci.2021, 22(21):11836.
  • Molecules.2021, 26(4):1084.
  • Korean Journal of Pharmacognosy2018, 49(1):76-83
  • Molecules.2019, 24(4):E709
  • FEBS Lett.2015, 589(1):182-7
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • Processes 2021, 9(5),894.
  • ...
  • 生物活性
    Description: Schisantherin A exhibits anti-tussive, sedative, anti-inflammatory, antioxidant, anti-osteoporotic, neuroprotective, cognition enhancing, and cardioprotective activities. Schisantherin A can significantly attenuate Aβ1-42-induced learning and memory impairment and noticeably improve the histopathological changes in the hippocampus. Schisantherin A exhibits neuroprotection against 1-methyl-4-phenylpyridinium ion (MPP(+)) through the regulation of two distinct pathways including increasing CREB-mediated Bcl-2 expression and activating PI3K/Akt survival signaling.
    Targets: ROS | NO | NOS | MAPK | PI3K | GSK-3 | IL Receptor | PGE | TNF-α | COX | ERK | p38MAPK | JNK | NF-kB | Beta Amyloid | Akt
    In vivo:
    PLoS One. 2013 Apr 19;8(4):e61590.
    Protective role of deoxyschizandrin and schisantherin A against myocardial ischemia-reperfusion injury in rats.[Pubmed: 23620773]

    METHODS AND RESULTS:
    Anesthetized male rats were treated once with deoxyschizandrin(DSD) and Schisantherin A(STA) (each 40 μmol/kg) through the tail vein after 45 min of ischemia, followed by 2-h reperfusion. Cardiac function, infarct size, biochemical markers, histopathology and apoptosis were measured and mRNA expression of gp91 (phox) in myocardial tissue assessed by RT-PCR. Neonatal rat cardiomyocytes were pretreated with DSD and STA and then damaged by H2O2. Cell apoptosis was tested by a flow cytometric assay. Compared with the I/R group: (i) DSD and STA could significantly reduce the abnormalities of LVSP, LVEDP, ±dp/dtmax and arrhythmias, thereby showing their protective roles in cardiac function; (ii) DSD and STA could significantly attenuate the infarct size and MDA release while increasing SOD activity, suggesting a role in reducing myocardial injury; (iii) tissue morphology and myocardial textual analysis revealed that DSD and STA mitigated changes in myocardial histopathology; (iv) DSD and STA decreased apoptosis (33.56±2.58% to 10.28±2.80% and 10.98±1.99%, respectively) and caspase-3 activity in the myocardium (0.62±0.02 OD/mg to 0.38±0.02 OD/mg and 0.32±0.02 OD/mg, respectively), showing their protective effects upon cardiomyocytes; and (v) DSD and STA had similar protective effects on I/R injury as those seen with the positive control metoprolol. In vitro, DSD and STA could significantly decrease the apoptosis of neonatal cardiomyocytes.
    CONCLUSIONS:
    These data suggest that DSD and STA can protect against myocardial I/R injury. The underlining mechanism may be related to their role in inhibiting cardiomyocyte apoptosis.
    Biochem Biophys Res Commun. 2014 Jul 4;449(3):344-50.
    Schisantherin A suppresses osteoclast formation and wear particle-induced osteolysis via modulating RANKL signaling pathways.[Pubmed: 2484538]
    Receptor activator of NF-κB ligand (RANKL) plays critical role in osteoclastogenesis. Targeting RANKL signaling pathways has been a promising strategy for treating osteoclast related bone diseases such as osteoporosis and aseptic prosthetic loosening. Schisantherin A (SA), a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent, but its effect on osteoclasts has been hitherto unknown.
    METHODS AND RESULTS:
    In the present study, SA was found to inhibit RANKL-induced osteoclast formation and bone resorption. The osteoclastic specific marker genes induced by RANKL including c-Src, SA inhibited OSCAR, cathepsin K and TRAP in a dose dependent manner. Further signal transduction studies revealed that SA down-regulate RANKL-induced nuclear factor-kappaB (NF-κB) signaling activation by suppressing the phosphorylation and degradation of IκBα, and subsequently preventing the NF-κB transcriptional activity. Moreover, SA also decreased the RANKL-induced MAPKs signaling pathway, including JNK and ERK1/2 posphorylation while had no obvious effects on p38 activation. Finally, SA suppressed the NF-κB and MAPKs subsequent gene expression of NFATc1 and c-Fos. In vivo studies, SA inhibited osteoclast function and exhibited bone protection effect in wear-particle-induced bone erosion model. Taken together, SA could attenuate osteoclast formation and wear particle-induced osteolysis by mediating RANKL signaling pathways.
    CONCLUSIONS:
    These data indicated that SA is a promising therapeutic natural compound for the treatment of osteoclast-related prosthesis loosening.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8637 mL 9.3186 mL 18.6372 mL 37.2745 mL 46.5931 mL
    5 mM 0.3727 mL 1.8637 mL 3.7274 mL 7.4549 mL 9.3186 mL
    10 mM 0.1864 mL 0.9319 mL 1.8637 mL 3.7274 mL 4.6593 mL
    50 mM 0.0373 mL 0.1864 mL 0.3727 mL 0.7455 mL 0.9319 mL
    100 mM 0.0186 mL 0.0932 mL 0.1864 mL 0.3727 mL 0.4659 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    当归酰基戈米辛H; Angeloylgomisin H CFN90710 66056-22-2 C28H36O8 = 500.58 10mg QQ客服:1457312923
    鹤庆五味子辛素; Schisanwilsonin H CFN92350 1181216-83-0 C30H32O9 = 536.6 5mg QQ客服:2159513211
    南五味子素; Kadsurin CFN92728 51670-40-7 C25H30O8 = 458.5 5mg QQ客服:215959384
    表戈米辛O; Epigomisin O CFN90733 73036-31-4 C23H28O7 = 416.46 5mg QQ客服:3257982914
    戈米辛O; Gomisin O CFN90751 72960-22-6 C23H28O7 = 416.46 10mg QQ客服:215959384
    当归酰基戈米辛 O; Angeloylgomisin O CFN89067 83864-69-1 C28H34O8 = 498.57 10mg QQ客服:2056216494
    鹤庆五味子癸素; Schisanwilsonin I CFN98732 1181216-84-1 C28H34O9 = 514.6 5mg QQ客服:1457312923
    内南五味子酯 C; Interiotherin C CFN92730 460090-65-7 C30H36O10 = 556.6 5mg QQ客服:2159513211
    滇藏五味子素G; Negsehisandrin G CFN90533 1023744-69-5 C28H36O7 = 484.6 10mg QQ客服:1457312923
    五味子酯乙; Schisantherin B CFN99924 58546-55-7 C28H34O9 = 514.57 20mg QQ客服:215959384

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