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  • 丹酚酸B

    Salvianolic acid B

    丹酚酸B
    产品编号 CFN99332
    CAS编号 115939-25-8
    分子式 = 分子量 C36H30O16 = 718.62
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The roots of Salvia miltiorrhiza Bge.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    丹酚酸B CFN99332 115939-25-8 10mg QQ客服:2159513211
    丹酚酸B CFN99332 115939-25-8 20mg QQ客服:2159513211
    丹酚酸B CFN99332 115939-25-8 50mg QQ客服:2159513211
    丹酚酸B CFN99332 115939-25-8 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Utah State University (USA)
  • St. Jude Children Research Hospital (USA)
  • University of Indonesia (Indonesia)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Kyung Hee University (Korea)
  • University of Fribourg (Switzerland)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
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  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Universiti Putra Malaysia(UPM) (Malaysia)
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  • University of Amsterdam (Netherlands)
  • University of British Columbia (Canada)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Hepatocell Carcinoma.2022, 9:327-341.
  • Ann Transl Med.2019, 7(23):731
  • Int Immunopharmacol.2019, 71:22-31
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • JMSACL2023, 09.002
  • ACS Omega2020, 5,33,20825-20830
  • Agriculture2022, 12(2),227.
  • Antioxidants (Basel).2020, 9(11):1121.
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  • BMC Complement Med Ther. 2020, 20(1):94.
  • Anal Biochem.2019, 569:10-15
  • J Appl Biol Chem2022, 65:343−348.
  • J Chromatogr A.2022, 1685:463640.
  • J Traditional Thai Medical Res.2022, 8(1):pp1-14.
  • Oxid Med Cell Longev2019, 9056845:13
  • Plants (Basel).2021, 10(11):2317.
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  • Front Endocrinol (Lausanne).2020, 11:568436.
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  • ...
  • 生物活性
    Description: Salvianolic acid B is a bioactive compound isolated from the Chinese medicinal herb Danshen, which is used for treating neoplastic and chronic inflammatory diseases in China, it shows a protective action against the ischemia-reperfusion induced injury in rat brain. It inhibited the expression of COX,ERK,TNF-α, NO.
    Targets: COX | ERK | TNF-α | NO
    In vitro:
    Eur J Pharmacol. 2012 Dec 15;697(1-3):81-7.
    Salvianolic acid B possesses vasodilation potential through NO and its related signals in rabbit thoracic aortic rings.[Pubmed: 23051676]
    Salviae miltiorrhizae, a traditional Chinese medicine, is widely used in the treatment of cardiovascular and cerebrovascular diseases. Salvianolic acid B is identified as one of the most important water-soluble active ingredients in Salviae miltiorrhizae and associated with the activation of Ca(2+) channel of cytomembrane. But the further mechanism of action was not very clearly.
    METHODS AND RESULTS:
    In our study, we investigated the vasodilation activity of Salvianolic acid B using the isolated thoracic aortic rings from Japanese white rabbit. Salvianolic acid B significantly released the contraction of the isolated thoracic aortic rings induced by phenylephrine and CaCl(2) while had no effects on the aortic rings with KCl stimulated. Different with Di-ao-xin-xue-kang capsule, Salvianolic acid B caused an increase of Ca(2+) in cytoplasm from not only activation of Ca(2+) channel in cytomembrane but also release of endogenous Ca(2+). Then, a series of endogenous Ca(2+) inhibitors were pretreated to explore the mechanism of Salvianolic acid B, and the results provided further evidences that Salvianolic acid B causes intracellular calcium release in ryanodine receptors-dependent manners. Moreover, combining l-arginine (l-Arg) with Salvianolic acid B promoted the vasodilation activity suggesting a relationship with nitric oxide (NO). To further investigated its mechanism, both guanylate cyclase (GC) inhibitor and NO Synthase inhibitor were used and demonstrated to block vasodilation activity of the aortic rings.
    CONCLUSIONS:
    Our findings reveal a NO-sGC-cGMP signals dependence mechanism of Salvianolic acid B on its vasodilation activity which provide an evidence for its subsequent application in clinic.
    In vivo:
    Asian Pac J Trop Med. 2014 Apr;7(4):280-4.
    Effect and mechanism of salvianolic acid B on the myocardial ischemia-reperfusion injury in rats.[Pubmed: 24507676]
    To investigate the effect of Salvianolic acid B on rats with myocardial ischemia-reperfusion injury.
    METHODS AND RESULTS:
    SD rats were randomly divided into five groups (n=10 in each group): A sham operation group, B ischemic reperfusion group model group, C low dose Salvianolic acid B group, D median dose Salvianolic acid B group, E high dose Salvianolic acid B group. One hour after establishment of the myocardial ischemia-reperfusion model, the concentration and the apoptotic index of the plasma level of myocardial enzymes (CTn I, CK-MB), SOD, MDA, NO, ET were measured. Heart tissues were obtained and micro-structural changes were observed. RESULTS: Compared the model group, the plasma CTn, CK-MB, MDA and ET contents were significantly increased, NO, T-SOD contents were decreased in the treatment group (group C, D, and E) (P<0.05); compared with group E, the plasma CTn I, CK-MB, MDA and ET levels were increased, the NO, T-SOD levels were decreased in groups C and D (P<0.05). Infarct size was significantly reduced, and the myocardial ultrastructural changes were improved significantly in treatment group.
    CONCLUSIONS:
    Salvianolic acid B has a significant protective effect on myocardial ischemia-reperfusion injury. It can alleviate oxidative stress, reduce calcium overload, improve endothelial function and so on.
    Int J Biochem Cell Biol. 2014 Jun;51:1-9.
    Salvianolic acid B promotes osteogenesis of human mesenchymal stem cells through activating ERK signaling pathway.[Pubmed: 24657587]
    Salvianolic acid B, a major bioactive component of Chinese medicine herb, Salvia miltiorrhiza, is widely used for treatment of cardiovascular diseases. Our recent studies have shown that Salvianolic acid B can prevent development of osteoporosis. However, the underlying mechanisms are still not clarified clearly.
    METHODS AND RESULTS:
    In the present study, we aim to investigate the effects of Salvianolic acid B on viability and osteogenic differentiation of human mesenchymal stem cells (hMSCs). The results showed Salvianolic acid B (Sal B) had no obvious toxic effects on hMSCs, whereas Sal B supplementation (5μM) increased the alkaline phosphatase activity, osteopontin, Runx2 and osterix expression in hMSCs. Under osteogenic induction condition, Sal B (5μM) significantly promoted mineralization; and when the extracellular-signal-regulated kinases signaling (ERK) pathway was blocked, the anabolic effects of Sal B were diminished, indicating that Sal B promoted osteogenesis of hMSCs through activating ERK signaling pathway.
    CONCLUSIONS:
    The current study confirms that Sal B promotes osteogenesis of hMSCs with no cytotoxicity, and it may be used as a potential therapeutic agent for the management of osteoporosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3916 mL 6.9578 mL 13.9156 mL 27.8311 mL 34.7889 mL
    5 mM 0.2783 mL 1.3916 mL 2.7831 mL 5.5662 mL 6.9578 mL
    10 mM 0.1392 mL 0.6958 mL 1.3916 mL 2.7831 mL 3.4789 mL
    50 mM 0.0278 mL 0.1392 mL 0.2783 mL 0.5566 mL 0.6958 mL
    100 mM 0.0139 mL 0.0696 mL 0.1392 mL 0.2783 mL 0.3479 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    荆芥素A; Schizotenuin A CFN95614 144608-09-3 C36H28O16 = 716.6 10mg QQ客服:2159513211
    7'(Z)-(8''R,8'''R)-表-丹酚酸E; 7'(Z)-(8''R,8'''R)-epi-salvianolic acid E CFN80290 N/A C36H30O16 = 718.15 5mg QQ客服:1457312923
    迷迭香酸; Rosmarinic acid CFN99103 20283-92-5 C18H16O8 = 360.31 20mg QQ客服:1457312923
    迷迭香酸甲酯; Methyl rosmarinate CFN97567 99353-00-1 C19H18O8 = 374.4 20mg QQ客服:3257982914
    迷迭香酸-4-氧-葡萄糖苷; Rosmarinyl glucoside CFN95297 910028-78-3 C24H26O13 = 522.5 5mg QQ客服:1413575084
    Clinopodic acid E; Clinopodic acid E CFN95595 159736-38-6 C27H22O12 = 538.5 5mg QQ客服:3257982914
    丹酚酸D; Salvianolic acid D CFN90223 142998-47-8 C20H18O10 = 492.44 5mg QQ客服:215959384
    丹酚酸A; Salvianolic acid A CFN99161 96574-01-5 C26H22O10 = 494.45 20mg QQ客服:1457312923
    丹酚酸A甲酯; Methyl salvionolate A CFN92564 1015171-69-3 C27H24O10 = 508.5 5mg QQ客服:1457312923
    异丹酚酸C; Isosalvianolic acid C CFN92565 142115-17-1 C26H20O10 = 492.4 5mg QQ客服:3257982914

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