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  • 柴胡皂苷B1

    Saikosaponin B1

    柴胡皂苷B1
    产品编号 CFN99127
    CAS编号 58558-08-0
    分子式 = 分子量 C42H68O13 = 780.98
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Bupleurum chinense DC.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    柴胡皂苷B1 CFN99127 58558-08-0 10mg QQ客服:3257982914
    柴胡皂苷B1 CFN99127 58558-08-0 20mg QQ客服:3257982914
    柴胡皂苷B1 CFN99127 58558-08-0 50mg QQ客服:3257982914
    柴胡皂苷B1 CFN99127 58558-08-0 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Copenhagen University (Denmark)
  • University of Bordeaux (France)
  • University of Wollongong (Australia)
  • University of Vienna (Austria)
  • University of Hertfordshire (United Kingdom)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Cornell University (USA)
  • University of Zurich (Switzerland)
  • The University of Newcastle (Australia)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Amsterdam (Netherlands)
  • Chinese University of Hong Kong (China)
  • Lodz University of Technology (Poland)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci Rep.2019, 9(1):6429
  • Antioxidants (Basel).2022, 11(12):2496.
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • J Food Biochem.2020, 44(6):e13198.
  • Plant Pathology2022, 13527
  • Biosci. Rep.2020, 10.1024
  • Foods.2022, 11(12):1773.
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Nutrients.2021, 13(8):2901.
  • Biomolecules.2019, 9(11):E696
  • Industrial Crops and Products2019, 140:111612
  • Foods.2020, 9(10):1348.
  • Molecules.2018, 23(7):E1659
  • Curr Issues Mol Biol.2022, 44(10):5106-5116.
  • J Ginseng Res.2022, 46(1):104-114.
  • Chem Biol Interact.2019, 298:1-7
  • Food Res Int.2020, 133:109130.
  • J Pharmaceut Biomed2020, 178:112894
  • mBio.2020, 11(3):e00686-20.
  • United States Patent Application2020, 20200038363
  • Forensic Sci Int.2022, 341:111475.
  • FEBS Lett.2015, 589(1):182-7
  • FEBS Lett.2021, 595(20):2608-2615.
  • ...
  • 生物活性
    Description: Saikosaponin B1 may be as anti-schizophrenic candidate drugs, it can suppress the signal transduction after binding of EGF.
    Targets: EGFR
    In vitro:
    Biomed. Chromatogr., 2015, 30(3):191-6.
    Recognition and identification of active components from Radix Bupleuri using human neuroblastoma SH-SY5Y cells[Reference: WebLink]
    Aim to screen active components of Radix bupleuri (a traditional Chinese herb) and discover novel anti-schizophrenic candidate drugs by using human neuroblastoma SH-SY5Y cells. SH-SY5Y cells were used for preparation of the stationary phase in the Cell Membrane Chromatography (CMC) model.
    METHODS AND RESULTS:
    Retention components by the SH-SY5Y/CMC model were collected and then analyzed by GC/MS under the optimized conditions in offline conditions. After investigating the suitability and reliability of the SH-SY5Y/CMC method using amisulpride and haloperidol as standard compounds, this method was applied to screening active components from the extracts of Radix bupleuri. Retention components of SH-SY5Y/CMC model were saikosaponin A, saikosaponin B1, saikosaponin B2, saikosaponin C and saikosaponin D, which were identified by the GC/MS method. In vitro pharmacological trials-MTT, saikosaponin B1, saikosaponin B2 and saikosaponin C could protect SY5Y cells. The protect effect of saikosaponin B1 and saikosaponin C were concentration dependent. Saikosaponin A and saikosaponin D inhibited cell viability at concentrations greater than 30 μg/mL (P<0.05). Via SH-SY5Y/CMC method and SH-SY5Y MTT trial, we rapidly detected target components from Radix bupleuri, accurately identified them and found out their different effects on SH-SY5Y cells.
    CONCLUSIONS:
    Saikosaponin B1, saikosaponin B2 and saikosaponin C may be as anti-schizophrenic candidate drugs.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2804 mL 6.4022 mL 12.8044 mL 25.6089 mL 32.0111 mL
    5 mM 0.2561 mL 1.2804 mL 2.5609 mL 5.1218 mL 6.4022 mL
    10 mM 0.128 mL 0.6402 mL 1.2804 mL 2.5609 mL 3.2011 mL
    50 mM 0.0256 mL 0.128 mL 0.2561 mL 0.5122 mL 0.6402 mL
    100 mM 0.0128 mL 0.064 mL 0.128 mL 0.2561 mL 0.3201 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-羟基巴戟醌; 3-hydroxymorindone CFN80104 80368-74-7 C15H10O6 = 286.24 10mg QQ客服:215959384
    Pyranojacareubin; Pyranojacareubin CFN89137 78343-62-1 C23H20O6 = 392.40 5mg QQ客服:215959384
    Annphenone; Annphenone CFN95426 61775-18-6 C15H20O9 = 344.3 10mg QQ客服:2056216494
    Isolintetralin; Isolintetralin CFN92070 145459-30-9 C23H28O6 = 400.5 5mg QQ客服:2056216494

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