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  • 芸香内酯

    Rutamarin

    芸香内酯
    产品编号 CFN89223
    CAS编号 14882-94-1
    分子式 = 分子量 C21H24O5 = 356.41
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The herbs of Ruta angustifolia Pers.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    芸香内酯 CFN89223 14882-94-1 1mg QQ客服:215959384
    芸香内酯 CFN89223 14882-94-1 5mg QQ客服:215959384
    芸香内酯 CFN89223 14882-94-1 10mg QQ客服:215959384
    芸香内酯 CFN89223 14882-94-1 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Periyar University (India)
  • Regional Crop Research Institute (Korea)
  • University of Bordeaux (France)
  • University of Bonn (Germany)
  • Biotech R&D Institute (USA)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Universidad de Antioquia (Colombia)
  • University of Parma (Italy)
  • Universidad Industrial de Santander (Colombia)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of Indonesia (Indonesia)
  • Washington State University (USA)
  • Kyoto University (Japan)
  • Universita' Degli Studi Di Cagliari (Italy)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Biomol Struct Dyn.2022, 5;1-17.
  • QASCF2022, 14(4).
  • Cell Signal.2022, 99:110433.
  • Scientific World Journal.2014, 2014:654193
  • Int J Mol Sci.2023, 24(17):13230.
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Vietnam Journal of Food Control.2022, 5(3):pp.488-497.
  • BMC Microbiol.2019, 19(1):78
  • Trop J Pharm Res.2023, 22(3):283-288.
  • Biomolecules.2022, 12(12):1754.
  • Malaysian Journal of Analytical Sciences2022, 26(2):360-369.
  • Molecules2020, 25(4):892
  • Research on Crops.2017, 18(3):569
  • Planta Med.2019, 85(9-10):766-773
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • J Pharm Biomed Anal.2017, 140:274-280
  • Int J Mol Sci.2022, 23(11):6104.
  • Antioxidants (Basel).2022, 11(12):2411.
  • Regul Toxicol Pharmacol.2023, 142:105433.
  • Food Sci Biotechnol.2021, 30(2):217-226.
  • Int J Mol Sci.2017, 19(1)
  • Molecules2022, 27(9):2827.
  • Vietnam J. Chem.2023, 61(3),308-317
  • ...
  • 生物活性
    Description: (+)-Rutamarin is effective in inhibiting EBV DNA replication and virion production but shows little adverse effect on cell proliferation.It is a dual inducer of both GLUT4 translocation and expression efficiently ameliorates glucose homeostasis in insulin-resistant mice. Rutamarin exhibits remarkable cytotoxic activity against HT29 cells (IC50 value of 5.6 uM), it has the potential to be developed as an anticancer agent.
    Targets: Caspase | GLUT | PI3K | Akt
    In vitro:
    Pharmacogn Mag. 2017 Jul;13(Suppl 2):S179-S188.
    Rutamarin, an Active Constituent from Ruta angustifolia Pers., Induced Apoptotic Cell Death in the HT29 Colon Adenocarcinoma Cell Line.[Pubmed: 28808378]
    Ruta angustifolia Pers. is a perennial herb that is cultivated worldwide, including Southeast Asia, for the treatment of various diseases as traditional medicine. The purpose of the study was to identify an active principle of R. angustifolia and to investigate its effect on the HT29 cell death.
    METHODS AND RESULTS:
    The methanol and fractionated extracts (hexane, chloroform, ethyl acetate, and water) of R. angustifolia Pers. were initially investigated for their cytotoxic activity against two human carcinoma cell lines (MCF7 and HT29) and a normal human colon fibroblast cell line (CCD-18Co) using sulforhodamine B cytotoxicity assay. Eight compounds including Rutamarin were isolated from the active chloroform extract and evaluated for their cytotoxic activity against HT29 human colon carcinoma cell line and CCD-18Co noncancer cells. Further studies on the induction of apoptosis such as morphological examinations, biochemical analyses, cell cycle analysis, and caspase activation assay were conducted in Rutamarin-treated HT29 cells. Rutamarin exhibited remarkable cytotoxic activity against HT29 cells (IC50 value of 5.6 μM) but was not toxic to CCD-18Co cells. The morphological and biochemical hallmarks of apoptosis including activation of caspases 3, 8, and 9 were observed in Rutamarin-treated HT29 cells. These may be associated with cell cycle arrest at the G0/G1 and G2/M checkpoints, which was also observed in HT29 cells.
    CONCLUSIONS:
    The present study describes Rutamarin-induced apoptosis in the HT29 cell line for the first time and suggests that Rutamarin has the potential to be developed as an anticancer agent.
    Antiviral Res. 2014 Jul;107:95-101.
    Antiviral activity of topoisomerase II catalytic inhibitors against Epstein-Barr virus.[Pubmed: 24821256 ]
    Herpesviruses require several cellular proteins for their lytic DNA replication including topoisomerase II (Topo II). Thus, Topo II could be an effective drug target against herpesviral infection.
    METHODS AND RESULTS:
    In this study, we examined several Topo II catalytic inhibitors for their potentials in blocking EBV replication and becoming efficacious antiviral agents. Topo II catalytic inhibitors in general exhibited marked inhibition of EBV lytic replication and minimal cytotoxicity. In particular, (+)-rutamarin, with the best selectivity index (SI>63) among the inhibitors tested in this study, is effective in inhibiting EBV DNA replication and virion production but shows little adverse effect on cell proliferation, suggesting its potential to become an efficacious and safe drug for the treatment of human diseases associated with EBV infection.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8058 mL 14.0288 mL 28.0576 mL 56.1151 mL 70.1439 mL
    5 mM 0.5612 mL 2.8058 mL 5.6115 mL 11.223 mL 14.0288 mL
    10 mM 0.2806 mL 1.4029 mL 2.8058 mL 5.6115 mL 7.0144 mL
    50 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.1223 mL 1.4029 mL
    100 mM 0.0281 mL 0.1403 mL 0.2806 mL 0.5612 mL 0.7014 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-羟基-3-异戊烯基香豆素; 7-Hydroxy-3-prenylcoumarin CFN97429 86654-26-4 C14H14O3 = 230.3 5mg QQ客服:2056216494
    7-羟基-6-甲氧基-3-异戊烯基香豆素; 7-Hydroxy-6-methoxy-3-prenylcoumarin CFN98374 299159-90-3 C15H16O4 = 260.3 5mg QQ客服:1413575084
    3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin; 3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin CFN89287 61899-42-1 C15H16O4 = 260.28 5mg QQ客服:215959384
    状芸香素 ; Chalepensin CFN89033 13164-03-9 C16H14O3 = 254.28 5mg QQ客服:1413575084
    芸香内酯; Rutamarin CFN89223 14882-94-1 C21H24O5 = 356.41 5mg QQ客服:3257982914
    三叉苦甲素; Evodosin A CFN89021 1291053-38-7 C14H16O6 = 280.27 5mg QQ客服:1413575084
    12-氧代四环香豆素A; 12-Oxocalanolide A CFN97812 161753-49-7 C22H24O5 = 368.43 5mg QQ客服:2056216494
    胡桐素E; Calanolide E CFN99466 142566-61-8 C22H28O6 = 388.5 5mg QQ客服:3257982914
    7-氨基-4-甲基-3-香豆素醋酸; 7-Amino-4-methylcoumarin CFN90420 106562-32-7 C12H11NO4 = 233.22 5mg QQ客服:215959384

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