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  • 钩毛茜草素 C

    Rubioncolin C

    钩毛茜草素 C
    产品编号 CFN89245
    CAS编号 132242-52-5
    分子式 = 分子量 C27H22O6 = 442.46
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Quinones
    植物来源 The roots and rhizomes of Rubia podantha.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    钩毛茜草素 C CFN89245 132242-52-5 1mg QQ客服:2159513211
    钩毛茜草素 C CFN89245 132242-52-5 5mg QQ客服:2159513211
    钩毛茜草素 C CFN89245 132242-52-5 10mg QQ客服:2159513211
    钩毛茜草素 C CFN89245 132242-52-5 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Hawaii Cancer Center (USA)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Sanford Burnham Medical Research Institute (USA)
  • Heidelberg University (Germany)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Sri Ramachandra University (India)
  • Seoul National University (Korea)
  • Institute of Chinese Materia Medica (China)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Kyung Hee University (Korea)
  • National Chung Hsing University (Taiwan)
  • Chinese University of Hong Kong (China)
  • FORTH-IMBB (Greece)
  • Medizinische Universit?t Wien (Austria)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytomedicine.2019, 55:229-237
  • Int J Mol Sci.2021, 22(21):11447.
  • Mol Microbiol.2019, 112(1):317-332
  • Saudi Pharmaceutical Journal2023, 31(12):101829
  • Nat Prod Commun.2018, 10.1177
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Heliyon.2022, e12337.
  • Metabolites.2020, 10(11):440.
  • Planta Med.2016, 82(13):1208-16
  • VNU Journal of Science2023, 39(2):24-33.
  • Asian Pac J Cancer Prev.2021, 22(S1):97-106.
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Microb Biotechnol.2021, 14(5):2009-2024.
  • Molecules.2019, 24(4):E744
  • Heinrich Heine University Dusseldorf2021, 62203.
  • Pharmaceutics.2022, 14(12):2765.
  • Anticancer Res.2018, 38(4):2127-2135
  • Institute of Food Science & Technology2021, 56(11).
  • Phytochemistry Letters2015, 243-247
  • South African Journal of Botany2021, 142:114-123.
  • Front Chem.2022, 10:1048467.
  • Phytomedicine.2015, 22(14):1262-8
  • Toxins (Basel).2022, 14(12):824.
  • ...
  • 生物活性
    Description: Rubioncolin C shows good cytotoxicity with IC50 value of 1.53 uM and NF-κB inhibitory activity with IC50 value of 2.97 uM.
    Targets: NF-kB
    In vitro:
    Phytochemistry. 2017 Nov 10;145:153-160.
    Rubipodanones A-D, naphthohydroquinone dimers from the roots and rhizomes of Rubia podantha.[Pubmed: 29132078 ]
    Four previously undescribed naphthohydroquinone dimers named rubipodanones A-D, together with 19 known quinones containing three known napthohydroquinone dimers named Rubioncolin C, methyl 5-hydroxy-dinaphtho[1,2-2',3']furan-7,12-dione-6-carboxylate and rubialatin B, were isolated from the roots and rhizomes of Rubia podantha.
    METHODS AND RESULTS:
    Their structures and absolute configurations were determined mainly by NMR, X-ray diffraction, and computational methods. Rubipodanones C and D, the glycosides of rubipodanone A and a pair of C-3 epimer, are the first identified dimeric napthohydroquinone glycosides from the Rubia plants. All naphthohydroquinone dimers were evaluated for their cytotoxicities against ten tumor cell lines and effects on the tumor-associated NF-κB signaling pathway, and Rubioncolin C showed the best cytotoxicity with IC50 value of 1.53 μM and NF-κB inhibitory activity with IC50 value of 2.97 μM.
    CONCLUSIONS:
    These results also demonstrated that the key roles of C-3 configuration and sugar group for biological activities of rubipodanone C.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2601 mL 11.3005 mL 22.6009 mL 45.2018 mL 56.5023 mL
    5 mM 0.452 mL 2.2601 mL 4.5202 mL 9.0404 mL 11.3005 mL
    10 mM 0.226 mL 1.13 mL 2.2601 mL 4.5202 mL 5.6502 mL
    50 mM 0.0452 mL 0.226 mL 0.452 mL 0.904 mL 1.13 mL
    100 mM 0.0226 mL 0.113 mL 0.226 mL 0.452 mL 0.565 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    叶点霉素; Phyllostine CFN97901 27270-89-9 C7H6O4 = 154.1 5mg QQ客服:1413575084
    (4R)-3,4-二氢-4,8-二羟基-1(2H)-萘酮; Regiolone CFN96886 137494-04-3 C10H10O3 = 178.18 5mg QQ客服:3257982914
    2-羟基-1,4萘醌; 2-Hydroxy-1,4-naphoquinone CFN91715 83-72-7 C10H6O3 = 174.15 20mg QQ客服:2159513211
    胡桃酮,5-羟基对萘醌; Juglone CFN90497 481-39-0 C10H6O3 = 174.16 20mg QQ客服:3257982914
    2-甲氧基-1,4-萘并醌; 2-Methoxy-1,4-naphthoquinone CFN95269 2348-82-5 C11H8O3 = 188.2 20mg QQ客服:3257982914
    兰雪醌; Plumbagin CFN90444 481-42-5 C11H8O3 = 188.17 20mg QQ客服:2056216494
    梅笠草素; Chimaphilin CFN95676 482-70-2 C12H10O2 = 186.2 20mg QQ客服:3257982914
    7-(Hydroxymethyl)-2-methyl-1,4-naphthalenedione; 7-(Hydroxymethyl)-2-methyl-1,4-naphthalenedione CFN95672 145626-36-4 C12H10O3 = 202.2 10mg QQ客服:215959384
    新化合物33; New compound 33 CFN95706 N/A C18H20O8 = 364.4 5mg QQ客服:2159513211
    茅膏醌; Droserone CFN91989 478-40-0 C11H8O4 = 204.18 5mg QQ客服:2056216494

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