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  • 甲基异茜草素-1-甲醚

    Rubiadin 1-methyl ether

    甲基异茜草素-1-甲醚
    产品编号 CFN97227
    CAS编号 7460-43-7
    分子式 = 分子量 C16H12O4 = 268.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Anthraquinones
    植物来源 The herbs of Paederia scandens (Lour.) Merr.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甲基异茜草素-1-甲醚 CFN97227 7460-43-7 1mg QQ客服:1457312923
    甲基异茜草素-1-甲醚 CFN97227 7460-43-7 5mg QQ客服:1457312923
    甲基异茜草素-1-甲醚 CFN97227 7460-43-7 10mg QQ客服:1457312923
    甲基异茜草素-1-甲醚 CFN97227 7460-43-7 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universite de Lille1 (France)
  • Lund University (Sweden)
  • Max-Planck-Insitut (Germany)
  • Colorado State University (USA)
  • University of Bordeaux (France)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • University of Virginia (USA)
  • Universidad Veracuzana (Mexico)
  • Massachusetts General Hospital (USA)
  • University of Stirling (United Kingdom)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Universidad Industrial de Santander (Colombia)
  • Mendel University in Brno (Czech Republic)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2018, 19(9):E2601
  • Natural Product Communications2020, doi: 10.1177.
  • Indian J. of Experimental Bio.2020, 9(58).
  • Bio-protocol2018, 9(14):e3301
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • J Med Food.2021, 24(3):209-217.
  • Synthetic and Systems Biotechnology2023, j.synbio.
  • Antioxidants (Basel).2022, 11(12):2496.
  • J Hematol Oncol.2018, 11(1):112
  • PLoS One.2017, 12(3):e0173585
  • Neurochem Int.2020, 133:104629
  • Environ Toxicol.2021, doi: 10.1002
  • Front Nutr.2021, 8: 687851.
  • BMC Complement Altern Med.2018, 18(1):221
  • Molecules.2018, 23(9):E2121
  • Front Pharmacol.2021, 12:615157.
  • Molecules.2019, 24(11):E2102
  • Int. J. Mol. Sci. 2022, 23(3),1696.
  • Phytomedicine.2023, 117:154929.
  • Biomed Pharmacother.2020, 128:110318.
  • Nutrients.2020, 12(3):595.
  • Molecules.2018, 23(7):E1659
  • Natural Product Communications2020, doi: 10.1177.
  • ...
  • 生物活性
    Description: Rubiadin-1-methyl ether probed as Type I photosensitizers. Rubiadin 1-methyl ether decreases the number of parasites (schizonts) in a dose-dependent manner, and 100% of inhibition was obtained with 30 to 40 micrograms. Rubiadin-1-methyl ether shows strong enhancing activity for adipocyte differentiation, it could be beneficial in the treatment of diabetes. Rubiadin-1-methyl ether has therapeutic potential against osteoporosis, it can promote osteoblast proliferation and inhibit osteoclast TRAP activity and bone resorption, and the inhibitory effects on osteoclastic bone, antiosteoporotic activity of M. officinalis .
    Targets: Antifection
    In vitro:
    Nat Prod Res. 2012;26(18):1750-4.
    Anthraquinones from Morinda officinalis roots enhance adipocyte differentiation in 3T3-L1 cells.[Pubmed: 22008000]
    To search for anti-diabetic and insulin-sensitising natural products, the effect on adipocyte differentiation was investigated by assessing fat accumulation in 3T3-L1 preadipocytes using Oil Red O staining.
    METHODS AND RESULTS:
    Fractionation and separation of n-hexane and CHCl₃ fractions of Morinda officinalis (Rubiaceae) using several chromatographic methods led to the isolation of three anthraquinones, 1,2-dimethoxyanthraquinone (1), alizarin-2-methyl ether (2) and rubiadin-1-methyl ether (3). Among them, alizarin-2-methyl ether (2) showed the strongest enhancing activity, followed by Rubiadin 1-methyl ether (3) and 1,2-dimethoxyanthraquinone (1). At a concentration of 100 µM, alizarin-2-methyl ether (2) enhanced adipocyte differentiation by up to 131% (compared to insulin-treated cells).
    CONCLUSIONS:
    Thus, these compounds could be beneficial in the treatment of diabetes.
    Planta Med. 1992 Dec;58(6):533-4.
    Effects of three compounds extracted from Morinda lucida on Plasmodium falciparum.[Pubmed: 1484892]
    The effects of three compounds, digitolutein (1), rubiadin 1-methyl ether (2) and damnacanthal (3) extracted from the stem bark and the roots of Morinda lucida Benth. on the growth of Plasmodium falciparum in vitro were investigated.
    METHODS AND RESULTS:
    The number of parasites (schizonts) decreased significantly in a dose-dependent manner, and 100% of inhibition was obtained with 30 to 40 micrograms of each compound tested. The IC50 values were calculated.
    J Photochem Photobiol B. 2005 Jan 14;78(1):77-83.
    Natural anthraquinones probed as Type I and Type II photosensitizers: singlet oxygen and superoxide anion production.[Pubmed: 15629252 ]
    The photosensitizing properties of six anthraquinones (AQs): soranjidiol (1), soranjidiol-1-methyl ether (2), rubiadin (3), rubiadin-1-methyl ether (4), damnacanthal (5) and damnacanthol (6), isolated from leaves and stems of Heterophyllaea pustulata Hook. f. (Rubiaceae) were studied.
    METHODS AND RESULTS:
    By means of photobiological and photophysical methods in vitro, the type of photosensitization that these metabolites are capable of producing was determined. Whereas the photosensitized generation of superoxide anion radical (O(2)(-)) (Type I) was evaluated in leukocyte suspensions, singlet molecular oxygen ((1)O(2)) production (Type II) was examined in organic solution. In addition, the quantum yield of (1)O(2) (Phi) in chloroform was measured for those AQs that generate it.
    CONCLUSIONS:
    It was established that 4 behaves exclusively as a Type I photosensitizer. By contrast, the others AQs act by both types of mechanisms, among which 5 showed the largest Phi of (1)O(2).
    Biochem Biophys Res Commun . 2018 Dec 2;506(4):927-931.
    Rubiadin-1-methyl ether from Morinda officinalis How. Inhibits osteoclastogenesis through blocking RANKL-induced NF-κB pathway[Pubmed: 30392907]
    Abstract Rubiadin-1-methyl ether (RBM) is a natural anthraquinone compound isolated from the root of Morinda officinalis How. In our previous study, RBM was found to have inhibitory effects on the TRAP activity of osteoclasts, which means that RBM may be a candidate for therapy of bone diseases characterized by enhanced bone resorption. However, the further effect of RBM on osteoclasts and the underlying mechanism remain unclear. In the present study, we investigated the effects of RBM isolated from Morinda officinalis How. on osteoclasts derived from bone marrow macrophages (BMMs) and the underlying mechanism in vitro. RBM at the dose that did not affect the viability of cells significantly inhibited RANKL-induced osteoclastogenesis and actin ring formation of osteoclast, while RBM performed a stronger effect at the early stage. In addition, RBM downregulated the expression of osteoclast-related proteins, including nuclear factor of activated T cells cytoplasmic 1 (NFATc1), cellular oncogene Fos (c-Fos), matrix metallopeptidase 9 (MMP-9) and cathepsin K (CtsK) as shown by Western blot. Furthermore, RBM inhibited the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decreased the nuclear translocation of p65. Collectively, the results suggest that RBM inhibit osteoclastic bone resorption through blocking NF-κB pathway and may be a promising agent for the prevention and treatment of bone diseases characterized by excessive bone resorption.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7272 mL 18.6359 mL 37.2717 mL 74.5434 mL 93.1793 mL
    5 mM 0.7454 mL 3.7272 mL 7.4543 mL 14.9087 mL 18.6359 mL
    10 mM 0.3727 mL 1.8636 mL 3.7272 mL 7.4543 mL 9.3179 mL
    50 mM 0.0745 mL 0.3727 mL 0.7454 mL 1.4909 mL 1.8636 mL
    100 mM 0.0373 mL 0.1864 mL 0.3727 mL 0.7454 mL 0.9318 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2-羟基-3-羟甲基蒽醌 ; 2-Hydroxy-3-(hydroxymethyl)anthraquinone CFN92112 68243-30-1 C15H10O4 = 254.2 5mg QQ客服:2159513211
    锈色洋地黄醌醇; Digiferruginol CFN92536 24094-45-9 C15H10O4 = 254.2 5mg QQ客服:3257982914
    2-甲基蒽醌; Tectoquinone CFN92570 84-54-8 C15H10O2 = 222.2 20mg QQ客服:2159513211
    2-羟基-3-甲基蒽醌; 2-Hydroxy-3-methylanthraquinone CFN99810 17241-40-6 C15H10O3 = 238.2 10mg QQ客服:2056216494
    1-羟基-2-甲基蒽醌; 1-Hydroxy-2-methylanthraquinone CFN92567 6268-09-3 C15H10O3 = 238.2 5mg QQ客服:215959384
    1,2-二羟基-3-甲基蒽醌; 1,2-dihydroxy-3-methyl-anthracene-9,10-dione CFN92558 602-63-1 C15H10O4 = 254.2 5mg QQ客服:1413575084
    洋地黄蒽醌; Digitolutein CFN92109 477-86-1 C16H12O4 = 268.3 5mg QQ客服:215959384
    甲基异茜草素-1-甲醚; Rubiadin 1-methyl ether CFN97227 7460-43-7 C16H12O4 = 268.3 10mg QQ客服:1457312923
    茜根定; Rubiadin CFN99270 117-02-2 C15H10O4 = 254.2 10mg QQ客服:3257982914
    芦西定; Lucidin CFN80213 478-08-0 C15H10O5 = 270.05 5mg QQ客服:2159513211

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