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  • 8-羟基白鲜碱

    Robustine

    8-羟基白鲜碱
    产品编号 CFN96362
    CAS编号 2255-50-7
    分子式 = 分子量 C12H9NO3 = 215.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The stem woods of Zanthoxylum avicennae.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    8-羟基白鲜碱 CFN96362 2255-50-7 1mg QQ客服:3257982914
    8-羟基白鲜碱 CFN96362 2255-50-7 5mg QQ客服:3257982914
    8-羟基白鲜碱 CFN96362 2255-50-7 10mg QQ客服:3257982914
    8-羟基白鲜碱 CFN96362 2255-50-7 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universita' Degli Studi Di Cagliari (Italy)
  • Max-Planck-Insitut (Germany)
  • Periyar University (India)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Universidade Federal de Santa Catarina (Brazil)
  • Aveiro University (Portugal)
  • University of East Anglia (United Kingdom)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Tohoku University (Japan)
  • Kitasato University (Japan)
  • University of Fribourg (Switzerland)
  • University of Zurich (Switzerland)
  • University of Bonn (Germany)
  • Universidade de Franca (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Cell Biochem.2022, 123(7):1222-1236.
  • Journal of Functional Foods2022, 91:105019.
  • Pharmaceutics.2021, 13(7):1028.
  • Microorganisms.2021, 9(12):2514.
  • Nutrients.2022, 14(19):4170.
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • Journal of Phytopathology2021, 169,Issue11-12.
  • Nutraceuticals2022, 2(3),150-161
  • Molecules2022, 27(11):3606.
  • Molecules.2021, 26(8):2161.
  • Reprod Toxicol.2020, 96:1-10.
  • Sci Adv.2018, 4(10)
  • J Exp Bot.2016, 67(12):3777-88
  • Pharmaceuticals (Basel). 2021, 14(10):986.
  • Aging (Albany NY).2021, 13(19):22867-22882.
  • Scientific World Journal.2014, 2014:654193
  • Molecules.2023, 28(16):6025.
  • 2023, 24(6):5769.Int J Mol Sci.
  • Int J Mol Sci.2019, 21(1):E265
  • Anticancer Res.2021, 41(3):1357-1364.
  • Anat Rec (Hoboken).2021, 304(2):323-332.
  • Korean J. Medicinal Crop Sci2021, 10:345-352.
  • Evid Based Complement Alternat Med.2021, 2021:8707280.
  • ...
  • 生物活性
    Description: Robustine may have anti-inflammatory activity, it exhibits inhibition (IC 50 < or = 18.19 microM) of superoxide anion generation by human neutrophils in response to formyl- l-methionyl- l-leucyl- l-phenylalanine/cytochalasin B (FMLP/CB).
    Targets: Immunology & Inflammation related | PDE
    In vitro:
    J Nat Prod. 2008 Feb;71(2):212-7.
    Neolignans, a coumarinolignan, lignan derivatives, and a chromene: anti-inflammatory constituents from Zanthoxylum avicennae.[Pubmed: 18211005 ]

    METHODS AND RESULTS:
    Eight new compounds, including four new neolignans, (7' S,8' S)-bilagrewin ( 1), (7' S,8' S)-5-demethoxybilagrewin ( 2), (7' S,8' S)-5- O-demethyl-4'- O-methylbilagrewin ( 3), and (7' S,8' S)-nocomtal ( 4), a new coumarinolignan, (7' S,8' S)-4'- O-methylcleomiscosin D ( 5), two new lignan derivatives, (+)-9'- O-( Z)-feruloyl-5,5'-dimethoxylariciresinol ( 6) and (+)-9'- O-( E)-feruloyl-5,5'-dimethoxylariciresinol ( 7), and a new chromene, ( E)-3-(2,2-dimethyl-2 H-chromen-6-yl)prop-2-enal ( 8), have been isolated from the stem wood of Zanthoxylum avicennae, together with 18 known compounds ( 9- 26). The structures of these new compounds were determined through spectroscopic and MS analyses.
    CONCLUSIONS:
    (7' S,8' S)-4'- O-Methylcleomiscosin D ( 5), cleomiscosin D ( 9), skimmianine ( 18), Robustine ( 19), and integrifoliolin ( 23) exhibited inhibition (IC 50 < or = 18.19 microM) of superoxide anion generation by human neutrophils in response to formyl- l-methionyl- l-leucyl- l-phenylalanine/cytochalasin B (FMLP/CB). In addition, skimmianine ( 18) inhibited FMLP/CB-induced elastase release with an IC 50 value of 19.15 +/- 0.66 microM.
    Arch Pharm Res. 2005 Jun;28(6):675-9.
    Inhibitory effects of furoquinoline alkaloids from Melicope confusa and Dictamnus albus against human phosphodiesterase 5 (hPDE5A) in vitro.[Pubmed: 16042076]
    Eight furoquinoline alkaloids were purified from two plants belonging to the Rutaceae family. Kokusaginine, skimmianine, evolitrine, and confusameline were purified from Melicope confusa, and haplopine, Robustine, dictamine, and gamma-fagarine from Dictamnus albus.
    METHODS AND RESULTS:
    In this study, the eight furoquinoline alkaloids were examined for inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro. DNA encoding the catalytic domain of human PDE5A was amplified from the mRNA of T24 cells by RT-PCR and was fused to GST in an expression vector. GST-tagged PDE5A was then purified by glutathione affinity chromatography and used in inhibition assays. Of the eight alkaloids, gamma-fagarine was the most potent inhibitor of PDE5A, and its single methoxy group at the C-8 position was shown to be critical for inhibitory activity.
    CONCLUSIONS:
    These results clearly illustrate the relationship between PDE5A inhibition and the methoxy group position in furoquinoline alkaloids.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.6468 mL 23.2342 mL 46.4684 mL 92.9368 mL 116.171 mL
    5 mM 0.9294 mL 4.6468 mL 9.2937 mL 18.5874 mL 23.2342 mL
    10 mM 0.4647 mL 2.3234 mL 4.6468 mL 9.2937 mL 11.6171 mL
    50 mM 0.0929 mL 0.4647 mL 0.9294 mL 1.8587 mL 2.3234 mL
    100 mM 0.0465 mL 0.2323 mL 0.4647 mL 0.9294 mL 1.1617 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    尖叶云香碱; 吴茱萸素; Evoxine CFN98849 522-11-2 C18H21NO6 = 347.4 5mg QQ客服:2056216494
    异白鲜碱; Isodictamnine CFN96762 484-74-2 C12H9NO2 = 199.20 5mg QQ客服:1413575084
    异榆桔碱; Isopteleine CFN96763 2181-84-2 C13H11NO3 = 229.23 5mg QQ客服:2056216494
    异斑点沸林草碱; Isomaculosidine CFN96765 518-96-7 C14H13NO4 = 259.26 5mg QQ客服:3257982914
    8-羟基白鲜碱; Robustine CFN96362 2255-50-7 C12H9NO3 = 215.2 5mg QQ客服:3257982914
    gamma-花椒碱; gamma-Fagarine CFN98858 524-15-2 C13H11NO3 = 229.2 5mg QQ客服:2056216494
    Maculosidin; Maculosidin CFN95126 522-19-0 C14H13NO4 = 259.3 5mg QQ客服:215959384
    单叶芸香品碱; Haplopine CFN96010 5876-17-5 C13H11NO4 = 245.2 5mg QQ客服:2056216494
    茵芋碱; Skimmianin CFN92555 83-95-4 C14H13NO4 = 259.3 20mg QQ客服:1413575084
    7-异戊烯氧基-gamma-花椒碱; 7-Isopentenyloxy-gamma-fagarine CFN98242 23417-92-7 C18H19NO4 = 313.4 5mg QQ客服:2159513211

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