草质素苷

Rhodionin

	产品编号	CFN99758
	CAS编号	85571-15-9
	分子式 = 分子量	C₂₁H₂₀O₁₁ = 448.38
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The herbs of Rhodiola rosea
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产品名称	产品编号	CAS编号	包装	QQ客服
草质素苷	CFN99758	85571-15-9	1mg	QQ客服：3257982914
草质素苷	CFN99758	85571-15-9	5mg	QQ客服：3257982914
草质素苷	CFN99758	85571-15-9	10mg	QQ客服：3257982914
草质素苷	CFN99758	85571-15-9	20mg	QQ客服：3257982914

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Description:

Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs; they can significantly suppress the elevation of the postprandial blood triglyceride level, suggests that they may be to the treatment of lifestyle-related diseases such as hyperlipidemia and exogeneous obesity and to health foods. Rhodionin has antioxidant activity, it exhibits potent 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging activities, with IC50 values of 19.49 ± 0.21 uM.

Targets:

CYP450 2D6

In vitro:

Molecules. 2012 Sep 27;17(10):11484-94.

The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of Rhodiola sachalinensis A. BOR.[Pubmed: 23018923]

Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4'-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), Rhodionin (7), and rhodiosin (8).
METHODS AND RESULTS:
Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.In this study, 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity and nitrotetrazolium blue chloride (NBT) superoxide scavenging activity were measured to assess the antioxidant activity of the components from RRS. DPPH has the ability to easily accept hydrogen atoms because it contains an unstable element, the hydrazyl nitrogen, therefore, antioxidant activity can be measured because DPPH loses its violet color when it receives hydrogens from antioxidants [18]. Additionally, NBT has the ability to easily receive superoxide because it contains unstable anions. Therefore, antioxidant activity may be measured when NBT loses its yellow color upon reaction with abundant superoxide [19]. Among the compounds from RRS, 7(Rhodionin) and 8 exhibited the most potent DPPH free radical scavenging activities, with IC50 values of 19.49 ± 0.21 and 27.77 ± 0.61 μM, respectively, compared to the positive control, L-ascorbic acid (IC50 = 32.89 ± 0.70 μM). The other compounds did not exhibit activities in this assay up to 100 μM (Table 2).

In vivo:

Planta Med. 2008 Nov;74(14):1716-9.

Constituents of Rhodiola rosea showing inhibitory effect on lipase activity in mouse plasma and alimentary canal.[Pubmed: 18982538 ]

As a methanol extract of the rhizome of Rhodiola rosea inhibits the activity of lipase in isolated mouse plasma in vitro and in the mouse gastrointestinal tube in vivo, the active components in this plant were investigated.
METHODS AND RESULTS:
After fractionation and separation processes, rhodionin and rhodiosin were isolated as active ingredients. Their IC50 values were 0.093 mM and 0.133 mM in vitro, respectively. Both compounds significantly suppressed the elevation of the postprandial blood triglyceride level, e.g., by 45.6 % (150 mg/kg, 60 min after oral administration) and 57.6 % (200 mg/kg, 180 min after oral administration), respectively.
CONCLUSIONS:
Consequently, we anticipate the application of this plant and its constituents to the treatment of lifestyle-related diseases such as hyperlipidemia and exogeneous obesity and to health foods.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
望春花黄酮醇苷I; Buddlenoid A	CFN95025	142750-32-1	C₃₀H₂₆O₁₃ = 594.5	5mg	QQ客服：215959384
Chiirirhamnin; Chiirirhamnin	CFN92202	195450-50-1	C₂₇H₃₀O₁₅ = 594.5	5mg	QQ客服：215959384
山奈酚-7-O-新橘皮糖苷; Kaempferol-7-O-neohesperidoside	CFN70290	17353-03-6	C₂₇H₃₀O₁₅ = 594.5	5mg	QQ客服：1457312923
山奈酚7-O-芸香糖苷; Kaempferol 7-O-rutinoside	CFN91528	103102-81-4	C₂₇H₃₀O₁₅ = 594.5	5mg	QQ客服：215959384
异山柰素 7-芸香糖苷; Isokaempferide 7-rutinoside	CFN95635	18467-06-6	C₂₈H₃₂O₁₅ = 608.6	5mg	QQ客服：2159513211
山奈苷; Kaempferitrin	CFN98756	482-38-2	C₂₇H₃₀O₁₄ = 578.5	20mg	QQ客服：1457312923
3-O-(6’’-O-乙酰基)葡糖甙-7-O-鼠李糖苷堪非醇酯; Kaempferol 3-O-(6''-O-acetyl)glucoside-7-O-rhamnoside	CFN97134	66465-24-5	C₂₉H₃₂O₁₆ = 636.6	5mg	QQ客服：1413575084
山柰酚-3,4'-二-O-葡萄糖苷; Kaempferol 3,4'-di-O-glucoside	CFN95357	71939-16-7	C₂₇H₃₀O₁₆ = 610.5	5mg	QQ客服：2159513211
山奈酚 3,5-双葡萄糖苷; Kaempferol 3,5-O-diglucoside	CFN95487	205103-97-5	C₂₇H₃₀O₁₆ = 610.5	10mg	QQ客服：2159513211
山柰酚 3,4'-二葡萄糖-7-鼠李糖苷; Kaempferol 3,4'-diglucoside 7-rhamnoside	CFN70251	1131009-93-2	C₃₃H₄₀O₂₀ = 756.7	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2303 mL	11.1513 mL	22.3025 mL	44.605 mL	55.7563 mL
5 mM	0.4461 mL	2.2303 mL	4.4605 mL	8.921 mL	11.1513 mL
10 mM	0.223 mL	1.1151 mL	2.2303 mL	4.4605 mL	5.5756 mL
50 mM	0.0446 mL	0.223 mL	0.4461 mL	0.8921 mL	1.1151 mL
100 mM	0.0223 mL	0.1115 mL	0.223 mL	0.4461 mL	0.5576 mL

草质素苷

Rhodionin

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