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    产品编号 CFN98850
    CAS编号 522-12-3
    分子式 = 分子量 C21H20O11 = 448.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Apocynum venetum L.
    产品名称 产品编号 CAS编号 包装 QQ客服
    槲皮苷 CFN98850 522-12-3 10mg QQ客服:2159513211
    槲皮苷 CFN98850 522-12-3 20mg QQ客服:2159513211
    槲皮苷 CFN98850 522-12-3 50mg QQ客服:2159513211
    槲皮苷 CFN98850 522-12-3 100mg QQ客服:2159513211
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    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    doi: 10.1016/j.molcel.2017.10.022.

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    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
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    doi: 10.1038/nplants.2016.205.

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  • Universidad de Ciencias y Artes de Chiapas (Mexico)
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  • 生物活性
    Description: Quercitrin is an antibacterial agent and inhibits the oxidation of low-density lipoproteins and prevent an allergic reaction; quercitrin and DNJ in combination as a potent anticariogenic agent against S. mutans.Quercitrin has antioxidant, anti-inflammatory, anti-cancer, and anti-allergic activities. Quercitrin has antiproliferative and apoptotic effects on lung cancer cells and colon cancer cells by modulating the immune response; it promotes osteoblast differentiation in MC3T3-E1 cells and also inhibit osteoclastogenesis in RAW264.7 cells.
    Targets: Caspase | MMP(e.g.TIMP) | NF-kB | JNK | HO-1 | ERK | p38MAPK | PARP
    In vitro:
    Arch Med Res. 2014 Aug;45(6):445-54.
    Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer.[Pubmed: 25193878]
    Quercitrin (QR; quercetin-3-O-rhamnoside) has been used previously as an antibacterial agent and has been shown to inhibit the oxidation of low-density lipoproteins and prevent an allergic reaction. Furthermore, it was demonstrated that quercitrin exerts protective effects against H2O2-induced dysfunction in lung fibroblast cells. However, the mechanisms of quercitrin effects on cancer cell proliferation and apoptosis is not well understood. The aim of this study is to investigate the cytotoxic and apoptotic effects of quercitrin and the molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer (NSCLC) cell lines.
    Time- and dose-dependent antiproliferative and apoptotic effects of quercitrin determined by WST-1 cell proliferation assay, lactate dehydrogenase (LDH) cytotoxicity assay, determination of nucleosome enrichment factor, changes in caspase-3 activity, loss of mitochondrial membrane potential (MMP) and also the localization of phosphatidylserine in the plasma membrane. Changes in whole genome gene expression levels were examined by Illumina Human HT-12v4 beadchip microarrays. There were significant increases in caspase-3 activity, loss of MMP, and increases in apoptotic cell population in response to quercitrin in A549 and NCI-H358 NSCLC cells in a time- and dose-dependent manner.
    Our results demonstrated that genes involved in leukocyte transendothelial migration, cell adhesion and phosphatidylinositol signaling system pathways were the most statistically significant pathways in NCI-H358 and A549 cells. These results revealed that quercitrin has antiproliferative and apoptotic effects on lung cancer cells by modulating the immune response. After confirming its anticarcinogenic effects in vivo, quercitrin could be a novel and strong anticancer agent against NSCLC.
    PLoS One. 2014 Mar 12;9(3):e91736.
    Inhibition of major virulence pathways of Streptococcus mutans by quercitrin and deoxynojirimycin: a synergistic approach of infection control.[Pubmed: 24622055]
    To evaluate the synergistic effect of Quercitrin and Deoxynojirimycin (DNJ) together with their individual inhibitory effect against virulence pathways of Streptococcus mutans.
    MICs of both the compounds were determined by the microdilution method, followed by their in vitrosynergy using checkerboard and time kill assay. The nature of interaction was classified as synergistic on the basis of fractional inhibitory concentration index (FICI) value of ≤0.5. Furthermore, the activity of Quercitrin and DNJ was evaluated individually and in combination against various cariogenic properties of S. mutans UA159 such as acidogenesis, aciduracity, glucan production, hydrophobicity, biofilm and adherence. Moreover, expression of virulent genes in S. mutans was analysed by quantitative RT- PCR (qRT-PCR) and inhibition of F1F0-ATPase, lactate dehydrogenase and enolase was also evaluated. Finally, scanning electron microscopy (SEM) was used to investigate structural obliteration of biofilm. The in vitro synergism between Quercitrin and DNJ was observed, with a FICI of 0.313. Their MIC values were found to be 64 μg/ml and 16 μg/ml respectively. The synergistic combination consistently showed best activity against all the virulence factors as compared to Quercitrin and DNJ individually. A reduction in glucan synthesis and biofilm formation was observed at different phases of growth. The qRT-PCR revealed significant downregulation of various virulent genes. Electron micrographs depicted the obliteration of biofilm as compared to control and the activity of cariogenic enzymes was also inhibited.
    The whole study reflects a prospective role of Quercitrin and DNJ in combination as a potent anticariogenic agent against S. mutans.
    In vivo:
    Eur J Immunol. 2005 Feb;35(2):584-92.
    In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway.[Pubmed: 15668926 ]
    Quercetin is a common antioxidant flavonoid found in vegetables, which is usually present in glycosylated forms, such as quercitrin (3-rhamnosylquercetin). Previous in vitro experiments have shown that quercetin exerts a bigger effect than quercitrin in the down-regulation of the inflammatory response. However, such results have not been reproduced in in vivo experimental models of intestinal inflammation, in which quercetin did not show beneficial effects while its glycosides, quercitrin or rutin, have demonstrated their effectiveness.
    In this study, we have reported that the in vivo effects of quercitrin in the experimental model of rat colitis induced by dextran sulfate sodium can be mediated by the release of quercetin generated after glycoside's cleavage by the intestinal microbiota. This is supported by the fact that quercetin, but not quercitrin, is able to down-regulate the inflammatory response of bone marrow-derived macrophages in vitro. Moreover, we have demonstrated that quercetin inhibits cytokine and inducible nitric oxide synthase expression through inhibition of the NF-kappaB pathway without modification of c-Jun N-terminal kinase activity (both in vitro and in vivo).
    As a conclusion, our report suggests that quercitrin releases quercetin in order to perform its anti-inflammatory effect which is mediated through the inhibition of the NF-kappaB pathway.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2302 mL 11.1508 mL 22.3015 mL 44.603 mL 55.7538 mL
    5 mM 0.446 mL 2.2302 mL 4.4603 mL 8.9206 mL 11.1508 mL
    10 mM 0.223 mL 1.1151 mL 2.2302 mL 4.4603 mL 5.5754 mL
    50 mM 0.0446 mL 0.223 mL 0.446 mL 0.8921 mL 1.1151 mL
    100 mM 0.0223 mL 0.1115 mL 0.223 mL 0.446 mL 0.5575 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    槲皮素-7-葡萄糖苷; 槲皮素-7-O-beta-D-吡喃葡萄糖苷; Quercetin-7-O-beta-D-glucopyranoside CFN99771 491-50-9 C21H20O12 = 464.38 10mg QQ客服:1413575084
    槲皮素-7-O-(6″-O-丙二酰基)-β-D-葡萄糖苷; Quercetin 7-O-(6''-O-malonyl)-beta-D-glucoside CFN95208 98767-37-4 C24H22O15 = 550.4 5mg QQ客服:2932563308
    栎草亭-7-O-葡萄糖苷; Quercetagetin-7-O-glucoside CFN90855 548-75-4 C21H20O13 = 480.4 10mg QQ客服:3257982914
    Gossypin; Gossypin CFN91987 652-78-8 C21H20O13 = 480.38 20mg QQ客服:1457312923
    棉皮素-8-O-葡萄糖醛酸苷; Hibifolin CFN70410 55366-56-8 C21H18O14 = 494.4 20 mg QQ客服:1413575084
    槲皮素-3-O-葡萄糖-7-O-鼠李糖苷; Quercetin 3-O-glucoside-7-O-rhamnoside CFN90738 18016-58-5 C27H30O16 = 610.52 5mg QQ客服:2932563308
    Clovin; Clovin CFN90913 81970-00-5 C33H40O20 = 756.66 5mg QQ客服:3257982914
    槲皮素-3-O-槐二糖-7-O-鼠李糖苷; Quercetin 3-O-sophoroside-7-O-rhamnoside CFN91129 64828-40-6 C33H40O21 = 772.7 5mg QQ客服:2159513211
    槲皮素-3-O-beta-D-葡萄糖-7-O-beta-D-龙胆双糖苷; Quercetin 3-O-beta-D-glucose-7-O-beta-D-gentiobioside CFN90920 60778-02-1 C33H40O22 = 788.66 20mg QQ客服:1457312923
    槲皮素-3-芸香糖苷-7-葡萄糖苷; Quercetin 3-rutinoside 7-glucoside CFN70335 30311-61-6 C33H40O21 = 772.7 5mg QQ客服:2159513211





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