Info: Read More
  • 中药标准品生产商,产品定制服务
  • 伪金丝桃素

    Pseudohypericin

    伪金丝桃素
    产品编号 CFN99591
    CAS编号 55954-61-5
    分子式 = 分子量 C30H16O9 = 520.44
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Anthraquinones
    植物来源 The herbs of Hypericum perforatum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    伪金丝桃素 CFN99591 55954-61-5 1mg QQ客服:215959384
    伪金丝桃素 CFN99591 55954-61-5 5mg QQ客服:215959384
    伪金丝桃素 CFN99591 55954-61-5 10mg QQ客服:215959384
    伪金丝桃素 CFN99591 55954-61-5 20mg QQ客服:215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universitas Airlangga (Indonesia)
  • University of Hawaii Cancer Center (USA)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Julius Kühn-Institut (Germany)
  • Aarhus University (Denmark)
  • University of Mysore (India)
  • University of East Anglia (United Kingdom)
  • University of Melbourne (Australia)
  • Deutsches Krebsforschungszentrum (Germany)
  • Rio de Janeiro State University (Brazil)
  • University Medical Center Mainz (Germany)
  • University of Vigo (Spain)
  • University of South Australia (Australia)
  • Universidad de La Salle (Mexico)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2022, 27(7):2360.
  • Pharmaceuticals (Basel).2020, 13(10):302.
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • PLoS One.2021, 16(9):e0257243.
  • Nutrients.2019, 11(4):E936
  • Phytother Res.2019, 33(7):1784-1793
  • University of Central Lancashire2017, 20472
  • BMC Plant Biol.2021, 21(1):60.
  • Molecules 2022, 27(3),960.
  • Environ Toxicol.2023, 23929.
  • Phytother Res.2015, 29(7):1088-96
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • BMB Rep.2020, 53(4):218-222.
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • Mol Cells.2015, 38(9):765-72
  • Research on Crops.2017, 18(2)
  • Srinagarind Medical Journal2017, 32(1)
  • LWT-Food Sci Technol2020, 109163
  • Antioxidants (Basel).2022, 11(12):2411.
  • Evid Based Complement Alternat Med.2021, 8855980.
  • Biomed Pharmacother.2022, 156:113929.
  • Molecules.2017, 22(11)
  • Molecules.2017, 22(6)
  • ...
  • 生物活性
    Description: Pseudohypericin has photocytotoxic, and antiretroviral activities, it has potential therapeutic value in diseases such as AIDS. Pseudohypericin can inhibit LPS-stimulated PGE2 and NO in mouse macrophages by potentiating suppressor of cytokine signaling 3 (SOCS3) expression, it has anti-tumor potential.
    Targets: PGE | NO | SOCS3
    In vitro:
    J.Photoch.Photobiol. B , 1998, 45(2-3):87-94.
    Photocytotoxic effect of pseudohypericin versus hypericin.[Reference: WebLink]
    Pseudohypericin and hypericin, the major photosensitizing constituents of Hypericum perforatum, are believed to cause hypericism.
    METHODS AND RESULTS:
    Since hypericin has been proposed as a photosensitizer for photodynamic cancer therapy, the photocytotoxicity of its congener Pseudohypericin has been investigated. The presence of foetal calf serum (FCS) or albumin extensively inhibits the photocytotoxic effect of Pseudohypericin against A431 tumour cells, and is associated with a large decrease in cellular uptake of the compound. These results suggest that Pseudohypericin, in contrast to hypericin, interacts strongly with constituents of FCS, lowering its interaction with cells.
    CONCLUSIONS:
    Since Pseudohypericin is two to three times more abundant in Hypericum than hypericin and the bioavailabilities of Pseudohypericin and hypericin after oral administration are similar, these results suggest that hypericin, and not Pseudohypericin, is likely to be the constituent responsible for hypericism. Moreover, the dramatic decrease of photosensitizing activity of Pseudohypericin in the presence of serum may restrict its applicability in clinical situations.
    P. Natl. Acad. Sci., 1989, 86(15):5963-7.
    Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin.[Reference: WebLink]

    METHODS AND RESULTS:
    Administration of the aromatic polycyclic dione compounds hypericin or Pseudohypericin to experimental animals provides protection from disease induced by retroviruses that give rise to acute, as well as slowly progressive, diseases. For example, survival from Friend virus-induced leukemia is significantly prolonged by both compounds, with hypericin showing the greater potency. Viremia induced by LP-BM5 murine immunodeficiency virus is markedly suppressed after infrequent dosage of either substance. These compounds affect the retroviral infection and replication cycle at least at two different points: (i) Assembly or processing of intact virions from infected cells was shown to be affected by hypericin. Electron microscopy of hypericin-treated, virus-producing cells revealed the production of particles containing immature or abnormally assembled cores, suggesting the compounds may interfere with processing of gag-encoded precursor polyproteins. The released virions contain no detectable activity of reverse transcriptase. (ii) Hypericin and Pseudohypericin also directly inactivate mature and properly assembled retroviruses as determined by assays for reverse transcriptase and infectivity.
    CONCLUSIONS:
    Accumulating data from our laboratories suggest that these compounds inhibit retroviruses by unconventional mechanisms and that the potential therapeutic value of hypericin and Pseudohypericin should be explored in diseases such as AIDS.
    Cancer Prev. Res., 2010, 3(12 Supplement).
    Download citationShare Request full-text Pseudohypericin in Hypericum perforatum inhibited LPS-stimulated PGE2 and NO in mouse macrophages by potentiating SOCS3 expression[Reference: WebLink]
    Hypericum perforatum, also known as ‘St John’s wort’, is one of the most studied medicinal plants. Despite its primary use as an anti-depression agent, certain compounds such as hypericin and hyperforin in H. perforatum extract have been shown to inhibit tumor growth by inducing apoptosis/necrosis and inhibiting angiogenesis. Using hypericin in photodynamic cancer therapy is also being studied. Our previous studies have demonstrated that H. perforatum extract and a group of 4 compounds in it, namely Pseudohypericin, amentoflavone, quercetin, and chlorogenic acid, decreased lipopolysaccharide (LPS)-stimulated macrophage inflammatory response, and identified the activation of suppressor of cytokine signaling 3 (SOCS3) as a candidate mechanism for this activity. Given that both inflammation and SOCS3 suppression are associated with tumor progression, we studied the role of SOCS3 activation in the anti-inflammatory activity of H. perforatum extract and its components.
    METHODS AND RESULTS:
    Specific siRNA was used to knockdown the expression of SOCS3 in RAW 264.7 mouse macrophages. Activation of SOCS3 in macrophages was measured at mRNA and protein levels using qRT-PCR and Western blot. H. perforatum extract at 30 μg/mL, the 4 compounds at the same concentrations as in the extract, and the combinations of individual compounds were applied to macrophages with and without SOCS3 knockdown to reveal whether their inhibition of LPS-stimulated prostaglandin E2 (PGE2) and nitric oxide (NO) was dependent on SOCS3. SOCS3 expression in the mouse macrophages was activated upon LPS stimulation and further potentiated by H. perforatum extract and the 4 compounds studied. SOCS3 siRNA transfection significantly compromised the activation of SOCS3. H. perforatum extract and the 4 compounds reduced LPS-stimulated PGE2 and NO production, but only the inhibitory effect of the 4 compounds was negated by SOCS3 knockdown. Combinations of two or three of the 4 compounds that include Pseudohypericin, the most essential component among the four that act synergistically in reducing macrophage inflammatory response, lost their inhibitory effect on PGE2 and NO production in SOCS3 knockdown cells.
    CONCLUSIONS:
    SOCS3 activation was critical for Pseudohypericin’s independent and interactive anti-inflammatory activity with amentoflavone, quercetin, and chlorogenic acid. H. perforatum extract utilized alternative mechanisms that are SOCS3 independent to inhibit macrophage inflammation. In addition to light-activated cytotoxicity and inhibition of angiogenesis, magnification of SOCS3 activation by H. perforatum extract might contribute to its anti-tumor potential.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9215 mL 9.6073 mL 19.2145 mL 38.429 mL 48.0363 mL
    5 mM 0.3843 mL 1.9215 mL 3.8429 mL 7.6858 mL 9.6073 mL
    10 mM 0.1921 mL 0.9607 mL 1.9215 mL 3.8429 mL 4.8036 mL
    50 mM 0.0384 mL 0.1921 mL 0.3843 mL 0.7686 mL 0.9607 mL
    100 mM 0.0192 mL 0.0961 mL 0.1921 mL 0.3843 mL 0.4804 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1,5,7'-联大黄素甲醚; Floribundone 1 CFN97845 118555-84-3 C32H22O10 = 566.52 5mg QQ客服:2056216494
    原金丝桃素; Protohypericin CFN93055 548-03-8 C30H18O8 = 506.46 5mg QQ客服:2159513211
    金丝桃素; Hypericin CFN99188 548-04-9 C30H16O8 = 504.45 20mg QQ客服:3257982914
    伪金丝桃素; Pseudohypericin CFN99591 55954-61-5 C30H16O9 = 520.44 5mg QQ客服:3257982914
    原伪金丝桃素; Protopseudohypericin CFN90677 54328-09-5 C30H18O9 = 522.46 10mg QQ客服:215959384
    番泻苷元A; Sennidin A CFN99597 641-12-3 C30H18O10 = 538.46 5mg QQ客服:1413575084
    番泻苷元B; Sennidin B CFN99598 517-44-2 C30H18O10 = 538.46 5mg QQ客服:1413575084
    番泻苷A; Sennoside A CFN99903 81-27-6 C42H38O20 = 862.74 20mg QQ客服:3257982914
    番泻苷B; Sennoside B CFN99904 128-57-4 C42H38O20 = 862.74 20mg QQ客服:2159513211
    番泻苷C; Sennoside C CFN99905 37271-16-2 C42H40O19 = 848.76 10mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产