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  • 原薯蓣皂苷

    Protodioscin

    原薯蓣皂苷
    产品编号 CFN99517
    CAS编号 55056-80-9
    分子式 = 分子量 C51H84O22 = 1049.21
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The rhizomes of Dioscorea nipponica Makino.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    原薯蓣皂苷 CFN99517 55056-80-9 10mg QQ客服:1413575084
    原薯蓣皂苷 CFN99517 55056-80-9 20mg QQ客服:1413575084
    原薯蓣皂苷 CFN99517 55056-80-9 50mg QQ客服:1413575084
    原薯蓣皂苷 CFN99517 55056-80-9 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad Industrial de Santander (Colombia)
  • Universite Libre de Bruxelles (Belgium)
  • Center for protein Engineering (CIP) (Belgium)
  • University of Auckland (New Zealand)
  • Charles Sturt University (Denmark)
  • Sri Ramachandra University (India)
  • Chinese University of Hong Kong (China)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Monash University Sunway Campus (Malaysia)
  • University of Indonesia (Indonesia)
  • FORTH-IMBB (Greece)
  • Srinakharinwirot University (Thailand)
  • University of Cincinnati (USA)
  • Aveiro University (Portugal)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Drug Des Devel Ther.2020, 14:969-976.
  • Sci Rep.2023, 13(1):21690.
  • Evid Based Complement Alternat Med.2020, 2020:8582318.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2022, 1203:123307.
  • Food Science and Biotechnology2015, 2205-2212
  • Pharmaceutics.2022, 14(12):2765.
  • QASCF2022, 14(4).
  • Biomol Ther (Seoul).2020, 28(6):542-548.
  • Int J Mol Sci.2019, 20(16):E4015
  • J Cell Mol Med.2023, 27(11):1592-1602.
  • Int J Biol Macromol.2020, 169:342-351
  • J Clin Med.2019, 8(10):E1664
  • Cell Rep.2022, 39(1):110643.
  • Antimicrob Agents Chemother.2020, AAC.01921-20.
  • South African J of Plant&Soil2018, 29-32
  • Front Chem.2022, 10:1048467.
  • Academic J of Second Military Medical University2018, 39(11)
  • Plants (Basel).2022, 11(16):2126.
  • Processes2021, 9(11),2065.
  • Front Pharmacol.2018, 9:236
  • Saudi Pharm J2020, 10.1016
  • Molecules.2019, 24(21):E3834
  • Heinrich Heine University Dusseldorf2021, 62203.
  • ...
  • 生物活性
    Description: Protodioscin has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties. It appears to possess aphrodisiac activity probably due to its androgen increasing property, it will be useful in developing health food supplement(s) and/or drug(s) against hyperlipidemia.
    Targets: Androgen Receptor
    In vitro:
    Phytomedicine . 2016 Nov 15;23(12):1504-1510.
    Protodioscin ameliorates fructose-induced renal injury via inhibition of the mitogen activated protein kinase pathway[Pubmed: 27765371]
    Abstract Background: High dietary fructose can cause metabolic syndrome and renal injury. Purpose: The effects of protodioscin on metabolic syndrome and renal injury were investigated in mice receiving high-dose fructose. Methods: Mice received 30% (w/v) fructose in water and standard chow for 6 weeks to induce metabolic syndrome and were divided into four groups to receive carboxymethylcellulose sodium, allopurinol (5 mg/kg) and protodioscin (5 and 10 mg/kg) continuously for 6 weeks, respectively. The glucose intolerance, serum uric acid (UA), blood urea nitrogen (BUN), creatinine (Cr), total cholesterol (TC), triglyceride (TG), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were determined. Results: Protodioscin significantly improved glucose intolerance and reduced the levels of serum UA, BUN, Cr, TC and TG. Histological examinations showed that protodioscin ameliorated glomerular and tubular pathological changes. Protodioscin significantly reduced renal concentrations of IL-1β, IL-6 and TNF-α by inhibiting the activation of nuclear factor-κB, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase. In addition, the effect of protodioscin on the mitogen activated protein kinases (MAPK) pathway was examined. Conclusion: Taken together, protodioscin is a potential drug candidate for high dietary fructose-induced metabolic syndrome and renal injury. Keywords: High fructose feeding; Inflammatory; MAPK pathway; Protodioscin; Renal injury.
    Steroids . 2016 Sep;113:52-63.
    Potential neuroprotection of protodioscin against cerebral ischemia-reperfusion injury in rats through intervening inflammation and apoptosis[Pubmed: 27343977]
    Abstract The aim of the current research is to investigate the cerebral-protection of protodioscin on a transient cerebral ischemia-reperfusion (I/R) model and to explore its possible underlying mechanisms. The rats were preconditioned with protodioscin at the doses of 25 and 50mgkg(-1) prior to surgery. Then the animals were subjected to right middle cerebral artery occlusion (MCAO) using an intraluminal method by inserting a thread (90min surgery). After the blood flow was restored in 24h via withdrawing the thread, some representative indicators for the cerebral injury were evaluated by various methods including TTC-staining, TUNEL, immunohistochemistry, and Western blotting. As compared with the operated rats without drug intervening, treatment with protodioscin apparently lowered the death rate and improved motor coordination abilities through reducing the deficit scores and cerebral infarct volume. What's more, an apparent decrease in neuron apoptosis detected in hippocampus CA1 and cortex of the ipsilateral hemisphere might attribute to alleviate the increase in Caspase-3 and Bax/Bcl-2 ratio. Meanwhile, concentrations of several main pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in the serum were also significantly suppressed. Finally, the NF-κB and IκBa protein expressions in the cytoplasm of right injured brain were remarkably up-regulated, while NF-κB in nucleus was down-regulated. Therefore, these observed findings demonstrated that protodioscin appeared to reveal potential neuroprotection against the I/R injury due to its anti-inflammatory and anti-apoptosis properties. This therapeutic effect was probably mediated by the inactivation of NF-κB signal pathways. Keywords: Bax/Bcl-2 ratio; Caspase-3; Middle cerebral artery occlusion; NF-κB; Pro-inflammatory cytokines; Protodioscin.
    Planta Med . 2010 Oct;76(15):1642-6.
    Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica[Pubmed: 20509104]
    Abstract Developing drugs against metabolic-related disorders, including obesity and hyperlipidemia, is of importance for human health. Here, a bioactive phytochemical, protodioscin, isolated from the rhizomes of Dioscorea nipponica (Rhizoma Dioscoreae Nipponicae), was identified for its anti-hyperlipidemic effect. In hyperlipidemic rats, the post-administration of protodioscin significantly reduced the time of blood coagulation. In addition, the blood levels of triglyceride, cholesterol, low-density and high-density lipoproteins were also changed accordingly. Taken together, this was the first report of an antihyperlipidemic effect of protodioscin. Its great availability in various vegetables and medicinal plants will be useful in developing health food supplement(s) and/or drug(s) against hyperlipidemia.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9531 mL 4.7655 mL 9.531 mL 19.062 mL 23.8275 mL
    5 mM 0.1906 mL 0.9531 mL 1.9062 mL 3.8124 mL 4.7655 mL
    10 mM 0.0953 mL 0.4765 mL 0.9531 mL 1.9062 mL 2.3827 mL
    50 mM 0.0191 mL 0.0953 mL 0.1906 mL 0.3812 mL 0.4765 mL
    100 mM 0.0095 mL 0.0477 mL 0.0953 mL 0.1906 mL 0.2383 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    重楼皂苷G; Polyphyllin G CFN99955 76296-75-8 C51H84O22 = 1049.22 5mg QQ客服:1457312923
    原皂苷Pa; Parisaponin I CFN90702 561007-63-4 C50H82O22 = 1034.0 5mg QQ客服:1457312923
    原皂苷Pb; Dichotomin CFN90703 53093-47-3 C57H94O26 = 1195.34 5mg QQ客服:2159513211
    知母皂苷B; Anemarsaponin B CFN99532 139051-27-7 C45H74O18 = 903.04 20mg QQ客服:215959384
    知母皂苷BIII; Anemarsaponin BIII CFN90778 142759-74-8 C45H74O18 = 903.1 5mg QQ客服:2159513211
    知母皂苷C; Timorsaponin C CFN90779 185432-00-2 C45H74O18 = 903.1 5mg QQ客服:2056216494
    伪原皂苷Pa; Parisyunnanoside B CFN90704 945865-37-2 C50H80O21 = 1016.0 10mg QQ客服:3257982914
    伪原薯蓣皂苷; Pseudoprotodioscin CFN90694 102115-79-7 C51H82O2 = 1031.18 20mg QQ客服:215959384
    黄山药皂苷C; Dioscoreside C CFN95345 C52H84O22 = 1061.2 5mg QQ客服:2056216494
    黄山药皂苷E; Dioscoreside E CFN95346 435321-73-6 C52H84O23 = 1077.2 5mg QQ客服:2159513211

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