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  • 奴夫卡因

    Procaine

    奴夫卡因
    产品编号 CFN94479
    CAS编号 59-46-1
    分子式 = 分子量 C13H20N2O2 = 236.31
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
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    奴夫卡因 CFN94479 59-46-1 10mg QQ客服:1457312923
    奴夫卡因 CFN94479 59-46-1 20mg QQ客服:1457312923
    奴夫卡因 CFN94479 59-46-1 50mg QQ客服:1457312923
    奴夫卡因 CFN94479 59-46-1 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Universidade de Franca (Brazil)
  • University of Helsinki (Finland)
  • Copenhagen University (Denmark)
  • Sri Ramachandra University (India)
  • University of Madras (India)
  • University of Illinois at Chicago (USA)
  • National Hellenic Research Foundation (Greece)
  • Universidad de La Salle (Mexico)
  • Mahidol University (Thailand)
  • Monash University (Australia)
  • Srinakharinwirot University (Thailand)
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  • Yale University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2021, 12:764297.
  • Phytomedicine.2019, 58:152893
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • Plants (Basel).2021, 10(4):702.
  • Pharmacognosy Journal, 2021, 13(5).
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Plant Foods Hum Nutr.2020, 10.1007
  • SBRAS2016, 12
  • Biomedicines.2021, 9(8):954.
  • Int J Mol Sci.2017, 19(1)
  • Cells.2022, 11(8), 1311.
  • Acta Physiologiae Plantarum2016, 38:7
  • Front Pharmacol.2020, 11:683.
  • J Separation Science & Technology2016, 51:1579-1588
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • J Ethnopharmacol.2023, 317:116789.
  • Antioxidants (Basel).2021, 10(10):1620.
  • J of Pharmaceutical Analysis2020, doi: 10.1016
  • J Nat Med.2022, 76(1):59-67.
  • JEJU National University2022, 24032.
  • Plant J.2017, 90(3):535-546
  • Molecules.2022, 27(13):4227.
  • ...
  • 生物活性
    Description: Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. It is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells, it inhibits the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells.
    Targets: DNA/RNA Synthesis
    In vitro:
    Cancer Res. 2003 Aug 15;63(16):4984-9.
    Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.[Pubmed: 12941824]
    Methylation-associated silencing of tumor suppressor genes is recognized as being a molecular hallmark of human cancer. Unlike genetic alterations, changes in DNA methylation are potentially reversible. This possibility has attracted considerable attention from a therapeutics standpoint. Nucleoside-analogue inhibitors of DNA methyltransferases, such as 5-aza-2'-deoxycytidine, are able to demethylate DNA and restore silenced gene expression. Unfortunately, the clinical utility of these compounds has not yet been fully realized, mainly because of their side effects. A few non-nucleoside inhibitors of DNA methyltransferases have been reported, including the anti-arrhythmia drug procainamide. Following this need to find new demethylating agents, we have tested the potential use of procaine, an anesthetic drug related to procainamide.
    METHODS AND RESULTS:
    Using the MCF-7 breast cancer cell line, we have found that procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands, such as those located in the promoter region of the RAR beta 2 gene, restoring gene expression of epigenetically silenced genes. This property may be explained by our finding that procaine binds to CpG-enriched DNA. Finally, procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest.
    CONCLUSIONS:
    Thus, procaine is a promising candidate agent for future cancer therapies based on epigenetics.
    Anesth Analg. 2003 Jul;97(1):85-90,
    Procaine and mepivacaine have less toxicity in vitro than other clinically used local anesthetics.[Pubmed: 12818948]
    The neurotoxicity of local anesthetics can be demonstrated in vitro by the collapse of growth cones and neurites in cultured neurons. We compared the neurotoxicity of procaine, mepivacaine, ropivacaine, bupivacaine, lidocaine, tetracaine, and dibucaine by using cultured neurons from the freshwater snail Lymnaea stagnalis. A solution of local anesthetics was added to the culture dish to make final concentrations ranging from 1 x 10(-6) to 2 x 10(-2) M. Morphological changes in the growth cones and neurites were observed and graded 1 (moderate) or 2 (severe). The median concentrations yielding a score of 1 were 5 x 10(-4) M for procaine, 5 x 10(-4) M for mepivacaine, 2 x 10(-4) M for ropivacaine, 2 x 10(-4) M for bupivacaine, 1 x 10(-4) M for lidocaine, 5 x 10(-5) M for tetracaine, and 2 x 10(-5) M for dibucaine. Statistically significant differences (P < 0.05) were observed between mepivacaine and ropivacaine, bupivacaine and lidocaine, lidocaine and tetracaine, and tetracaine and dibucaine. The order of neurotoxicity was procaine = mepivacaine < ropivacaine = bupivacaine < lidocaine < tetracaine < dibucaine. Although lidocaine is more toxic than bupivacaine and ropivacaine, mepivacaine, which has a similar pharmacological effect to lidocaine, has the least-adverse effects on cone growth among clinically used local anesthetics.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.2317 mL 21.1586 mL 42.3173 mL 84.6346 mL 105.7932 mL
    5 mM 0.8463 mL 4.2317 mL 8.4635 mL 16.9269 mL 21.1586 mL
    10 mM 0.4232 mL 2.1159 mL 4.2317 mL 8.4635 mL 10.5793 mL
    50 mM 0.0846 mL 0.4232 mL 0.8463 mL 1.6927 mL 2.1159 mL
    100 mM 0.0423 mL 0.2116 mL 0.4232 mL 0.8463 mL 1.0579 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    p-3-甲氨基正丙基苯酚; p-3-Methylamino propyl phenol CFN00078 32180-92-0 C10H15NO = 165.23 5mg QQ客服:1457312923
    盐酸多巴胺; Dopamine hydrochloride CFN90036 62-31-7 C8H11NO2 = 153.18 20mg QQ客服:2159513211
    肾上腺素; Adrenaline CFN90032 51-43-4 C9H13NO3 = 183.2 20mg QQ客服:2159513211
    去甲肾上腺素; Norepinephrine CFN90047 51-41-2 C8H11NO3 = 169.18 20mg QQ客服:1457312923
    3-羟基-2-苯基-丙酰胺; 3-Hydroxy-2-phenyl-propanamide CFN94011 56598-62-0 C9H11NO2 = 165.19 5mg QQ客服:1413575084
    α-乙酰氨基肉桂酸; 2-(Acetylamino)-3-phenyl-2-propenoic acid CFN98187 5469-45-4 C11H11NO3 = 205.21 20mg QQ客服:1413575084
    辛弗林; Synephrine CFN99551 94-07-5 C9H13NO2 = 167.21 20mg QQ客服:215959384
    大麦芽碱; Hordenine CFN99901 539-15-1 C10H15NO = 165.24 20mg QQ客服:3257982914
    N-甲基大麦芽碱; Candicine CFN91816 6656-13-9 C11H18NO = 180.3 5mg QQ客服:2056216494
    棍掌碱; 棍常碱; Coryneine CFN91803 7224-66-0 C11H18NO2 = 196.3 5mg QQ客服:2159513211

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