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  • 桔梗皂苷D2

    Platycodin D2

    桔梗皂苷D2
    产品编号 CFN93260
    CAS编号 66663-90-9
    分子式 = 分子量 C63H102O33 = 1387.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Platycodon grandiflorum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    桔梗皂苷D2 CFN93260 66663-90-9 1mg QQ客服:3257982914
    桔梗皂苷D2 CFN93260 66663-90-9 5mg QQ客服:3257982914
    桔梗皂苷D2 CFN93260 66663-90-9 10mg QQ客服:3257982914
    桔梗皂苷D2 CFN93260 66663-90-9 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plants (Basel).2022, 11(21):2947.
  • Plants (Basel).2021, 10(5):951.
  • J Appl Biol Chem2021, 64(3):245-251.
  • Agronomy2020, 10(3),388.
  • Front Pharmacol.2021, 12:744624.
  • Viruses.2017, 9(10)
  • J Nutr Biochem.2022, 107:109064.
  • Mutlu Yanic S, Ates EG. JOTCSA.2023, 10(4);893-902.
  • Biomed Pharmacother.2022, 145:112474.
  • Int J Mol Sci.2019, 20(3):E651
  • J Ethnopharmacol.2021, 267:113615.
  • Oncotarget.2017, 8(64):108006-108019
  • Biomed Pharmacother.2022, 146:112497.
  • Horticulture Research2022, uhac276.
  • Antioxidants (Basel).2022, 11(1):171.
  • Molecules.2019, 24(1):E159
  • Theoretical and Experimental Plant Physiology 2022, 34,53-62
  • Natural Product Communications2020, doi: 10.1177.
  • Pharmaceutics2022, 14(2),376.
  • Nat Plants.2016, 3:16205
  • Appl. Sci.2020, 10,1304
  • Aquaculture2017, 481:94-102
  • Biomed Pharmacother.2021, 137:111362.
  • ...
  • 生物活性
    Description: Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses. Polygalacin D2 has anti-cancer activity, it exhibits significant inhibition on the proliferation of five kinds of cultured human tumor cell lines.
    Targets: IFN-γ | IL Receptor | HBV
    In vitro:
    Planta Med. 2005 Jun;71(6):566-8.
    Isolation of a new saponin and cytotoxic effect of saponins from the root of Platycodon grandiflorum on human tumor cell lines.[Pubmed: 15971131]

    METHODS AND RESULTS:
    A novel triterpenoid saponin, deapioplatycoside E (1) was isolated from the root extract of Platycodon grandiflorum, together with the seven known saponins 2 - 8, i. e., platycoside E (2), deapioplatycodin D3 (3), platycodin D3 (4), polygalacin D2 (5), platycodin D2 (6), deapioplatycodin D (7) and platycodin D (8). The structure of the new saponin 1 was determined on the basis of spectral analysis and chemical evidence.
    CONCLUSIONS:
    The crude saponin fraction (ED50: ca. 10 - 15 microg/mL) and compounds 6 - 8 (ED50: ca. 4 - 18 microg/mL) exhibited significant inhibition on the proliferation of five kinds of cultured human tumor cell lines, i. e., A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitro.
    Chem Biodivers. 2010 Jan;7(1):178-85.
    Platycodin D2 improves specific cellular and humoral responses to hepatitis B surface antigen in mice.[Pubmed: 20087984 ]
    Platycodin D2 (PD2), a saponin isolated from the root of Platycodon grandiflorum, was evaluated for its haemolytic activity and adjuvant potential on the cellular and humoral immune responses to ovalbumin (OVA) in ICR mice.
    METHODS AND RESULTS:
    The HD(50) values of PD2 and Quil A were 18.57+/-1.37 and 5.76+/-0.23 microg/ml against 0.5% rabbit red blood cell, respectively, implicating the less haemolytic activity for PD2 than Quil A. ICR mice were immunized subcutaneously with OVA 100 microg alone or with OVA 100 microg dissolved in saline containing Alum (200 microg), or PD2 (25, 50, 75 or 100 microg) on Day 1 and 15. Two weeks later (Day 28), concanavalin A (Con A)-, lipopolysaccharide (LPS-) and OVA-stimulated splenocyte proliferation and OVA-specific antibodies in serum were measured. PD2 significantly enhanced the Con A-, LPS-, and OVA-induced splenocyte proliferation in the OVA-immunized mice (P<0.05, P<0.01 or P<0.001). OVA-specific IgG, IgG1, IgG2a, and IgG2b antibody titers in serum were also significantly enhanced by PD2 compared with OVA control group (P<0.05, P<0.01 or P<0.001). Further, the effects of PD2 on mRNA expression of cytokines and transcription factors in Con A-stimulated mice splenocytes were evaluated by RT-PCR analysis. PD2 significantly promoted the mRNA expression of cytokines IL-2, IFN-gamma, IL-4, and IL-10 and transcription factors T-bet and GATA-3 (P<0.05, P<0.01 or P<0.001).
    CONCLUSIONS:
    In conclusion, the results suggest that PD2 could be safely used as adjuvant eliciting Th1 and Th2 immune responses.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.7207 mL 3.6036 mL 7.2072 mL 14.4144 mL 18.018 mL
    5 mM 0.1441 mL 0.7207 mL 1.4414 mL 2.8829 mL 3.6036 mL
    10 mM 0.0721 mL 0.3604 mL 0.7207 mL 1.4414 mL 1.8018 mL
    50 mM 0.0144 mL 0.0721 mL 0.1441 mL 0.2883 mL 0.3604 mL
    100 mM 0.0072 mL 0.036 mL 0.0721 mL 0.1441 mL 0.1802 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    瓜子金皂苷XXXV; Polygalasaponin XXXV CFN95176 184479-28-5 C63H98O31 = 1351.5 5mg QQ客服:215959384
    远志皂苷B; Onjisaponin B CFN90600 35906-36-6 C75H112O35 = 1573.69 5mg QQ客服:1457312923
    瓜子金皂苷XXXI; Polygalasaponin XXXI CFN90728 79103-90-5 C75H112O36 = 1589.67 5mg QQ客服:215959384
    瓜子金皂苷XLIX; Polygalasaponin XLIX CFN95117 1033593-12-2 C64H102O33 = 1399.47 10mg QQ客服:1413575084
    冬青苷XLVIII; Ilexoside XLVIII CFN91698 129095-76-7 C42H66O15 = 811.0 5mg QQ客服:2056216494
    川续断皂苷VI; 木通皂苷D; Asperosaponin VI CFN99766 39524-08-8 C47H76O18 = 929.10 20mg QQ客服:215959384
    辽东楤木皂苷VII; Araloside VII CFN80402 340982-22-1 C54H88O24 = 1121.26 5mg QQ客服:2056216494
    常春藤苷D; 常春藤皂苷D; Hederacoside D CFN90184 760961-03-3 C53H86O22 = 1074.56 20mg QQ客服:1413575084
    瓜子金皂苷戊; Polygalasaponin E CFN95138 882664-72-4 C47H74O19 = 943.1 5mg QQ客服:2159513211
    瓜子金皂苷II; Polygalasaponin II CFN91789 162857-62-7 C48H78O19 = 959.12 5mg QQ客服:3257982914

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