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  • 球松素; 乔松酮

    Pinostrobin

    球松素; 乔松酮
    产品编号 CFN98739
    CAS编号 480-37-5
    分子式 = 分子量 C16H14O4 = 270.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Cajanus cajan
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    球松素; 乔松酮 CFN98739 480-37-5 10mg QQ客服:1457312923
    球松素; 乔松酮 CFN98739 480-37-5 20mg QQ客服:1457312923
    球松素; 乔松酮 CFN98739 480-37-5 50mg QQ客服:1457312923
    球松素; 乔松酮 CFN98739 480-37-5 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Florida A&M University (USA)
  • Yale University (USA)
  • University of Zurich (Switzerland)
  • University of Illinois (USA)
  • University of Canterbury (New Zealand)
  • Universidad Veracuzana (Mexico)
  • University of Melbourne (Australia)
  • Cornell University (USA)
  • Korea Food Research Institute(KFRI) (Korea)
  • Donald Danforth Plant Science Center (USA)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Seoul National University (Korea)
  • Kamphaengphet Rajabhat University (Thailand)
  • Gyeongsang National University (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Agric Food Chem.2018, 66(1):351-358
  • Srinagarind Medical Journal2019, 34(1)
  • J Mass Spectrom.2022, 57(2):e4810.
  • Cells.2021, 10(10):2633.
  • J Nat Med.2020, 74(3):550-560.
  • LWT2021, 150:112021.
  • LWT-Food Science and Technology2017, 75:488-496
  • Clin Exp Pharmacol Physiol.2020, doi: 10.1111
  • Int J Mol Sci.2022, 23(13):7115.
  • Phytomedicine.2019, 67:153159
  • Anal Sci.2019, 35(12):1317-1325
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Biomolecules2021, 11(10),1513.
  • Biosci Rep.2018, 38(4)
  • Oxid Med Cell Longev.2022, 2022:5888636.
  • J of Ana. Chem.2019, 74(11):1113-1121
  • Anal Chim Acta.2018, 1039:162-171
  • Molecules.2016, 21(6)
  • Nutrients.2018, 10(12):E1998
  • J Appl Biol Chem2023, 66:455−461
  • Pharmaceuticals (Basel).2020, 13(9):262.
  • J Biochem Mol Toxicol.2022, e23211.
  • ...
  • 生物活性
    Description: Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aβ(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis. Pinostrobin has anti-inflammatory, anti-hemorrhagic and analgesic activity, it can inhibit HSV-1 replication with 50% effective concentration (EC(50)) of 22.71 ± 1.72 ug/ml.
    Targets: TNF-α | IL Receptor | Beta Amyloid | Bcl-2/Bax | HSV
    In vitro:
    J Ethnopharmacol. 2014 Sep 29;155(3):1609-15.
    Inhibition of the toxic effects of Bothrops asper venom by pinostrobin, a flavanone isolated from Renealmia alpinia (Rottb.) MAAS.[Pubmed: 25138354]
    Renealmia alpinia has been traditionally used to treat snakebites by indigenous Embera-Katíos tribes belonging to the regions of Antioquia and Chocó, Colombia, and it has been shown to inhibit the enzymatic and biological activities of Bothrops venoms and their purified phospholipase A2 (PLA2) toxins. In addition to its common local usage against snakebites, Renealmia alpinia is commonly used to treat pain. To evaluate the inhibitory ability of pinostrobin, the main compound in the dichloromethane extract of Renealmia alpinia, on the toxic effects of Bothrops asper venom through in vitro and in vivo models and to evaluate its activity against pain and edema.
    METHODS AND RESULTS:
    Pinostrobin was isolated from the dichloromethane extract of Renealmia alpinia leaves. The protective properties of the extract and of pinostrobin against the indirect hemolytic, coagulant and proteolytic effects of Bothrops asper venom were evaluated in vitro, and the anti-hemorrhagic and anti-inflammatory activity were evaluated in vivo. Renealmia alpinia extract significantly inhibited the proteolytic activity and indirect hemolytic activity of Bothrops asper venom at a venom:extract ratio of 1:20. Moreover, the present data demonstrate that pinostrobin may mitigate some venom-induced local tissue damage due to hemorrhagic effects, and the compound is also responsible for the analgesic and anti-inflammatory activity of the extract from Renealmia alpinia. This is the first report to describe pinostrobin in the species Renealmia alpinia and its properties in vitro against Bothrops asper venom.
    CONCLUSIONS:
    Our studies of the activity of Renealmia alpinia against the venom of Bothrops asper have confirmed that this species possesses inhibitory effects against Bothrops asper venom in both in vitro and in vivo models and that these effects may be due to pinostrobin, supporting the traditional usage of the plant. Additionally, pinostrobin may be responsible for the anti-hemorrhagic and analgesic activity (peripheral analgesic activity) of Renealmia alpinia.
    Cell Mol Neurobiol. 2012 Nov;32(8):1223-30.
    Protective effects of pinostrobin on β-amyloid-induced neurotoxicity in PC12 cells.[Pubmed: 22565301]
    Pinostrobin, a potent flavonoid inducer, is the major and most active ingredient of Folium cajani. The present study aimed to investigate whether Pinostrobin could provide protective effect against Aβ(25-35)-induced neurotoxicity in cultured rat pheochromocytoma (PC12) cells.
    METHODS AND RESULTS:
    The PC12 cells were pretreated with different concentrations of Pinostrobin for 2 h, followed by the challenge with 20 μM Aβ(25-35) for 24 h. The results showed that pretreatment with Pinostrobin significantly elevated cell viability, decreased the lactate dehydrogenase activity, the levels of intracellular reactive oxygen species and calcium, and mitochondrial membrane potential in Aβ(25-35)-treated PC12 cells. In addition, Pinostrobin significantly suppressed the formation of DNA fragmentation and increased the ratio of Bcl-2/Bax.
    CONCLUSIONS:
    These results indicate that Pinostrobin was able to exert a neuroprotective effect against Aβ(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis.
    Phytomedicine. 2011 Jan 15;18(2-3):110-8.
    Activity investigation of pinostrobin towards herpes simplex virus-1 as determined by atomic force microscopy.[Pubmed: 20739162]
    In the present study, the antiviral activity of pinostrobin towards herpes simplex virus-1 (HSV-1) was investigated by MTT assay and atomic force microscopy.
    METHODS AND RESULTS:
    Pinostrobin can inhibit HSV-1 replication with 50% effective concentration (EC(50)) of 22.71 ± 1.72 μg/ml. MTT assay showed HSV-1 was significantly inhibited when pretreated with pinostrobin, with the inhibition of 85.69 ± 2.59%. Significant changes in morphology and size of HSV-1 were observed by atomic force microscopy (AFM) in response to pinostrobin treatment. AFM topography and phase images showed that with increasing time, the envelope was shedded and damaged, finally leading to virus inactivation. With increasing concentration, pinostrobin caused a gradual leakage, also contributing to breakage of the envelope and virus inactivation. Treatment effect of oral pinostrobin in vivo showed that pinostrobin (50mg/kg/dose) possesses definite therapeutical effect in the development of lesion score.
    CONCLUSIONS:
    In general, the results showed that AFM represents a powerful technique for the investigation of morphology and size of HSV-1 treated by antiviral agents. AFM is applicable to study chemically induced morphological changes at the nanometer level.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6996 mL 18.498 mL 36.9959 mL 73.9919 mL 92.4898 mL
    5 mM 0.7399 mL 3.6996 mL 7.3992 mL 14.7984 mL 18.498 mL
    10 mM 0.37 mL 1.8498 mL 3.6996 mL 7.3992 mL 9.249 mL
    50 mM 0.074 mL 0.37 mL 0.7399 mL 1.4798 mL 1.8498 mL
    100 mM 0.037 mL 0.185 mL 0.37 mL 0.7399 mL 0.9249 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    二氢黄芩素; Dihydrobaicalein CFN93796 35683-17-1 C15H12O5 = 272.3 5mg QQ客服:2056216494
    二氢木蝴蝶素A; Dihydrooroxylin A CFN92591 18956-18-8 C16H14O5 = 286.3 5mg QQ客服:2159513211
    5-羟基-6,7-二甲氧基黄烷酮; Onysilin CFN92422 73695-94-0 C17H16O5 = 300.3 5mg QQ客服:3257982914
    5-羟基-7,8-二甲氧基黄烷酮; 5-Hydroxy-7,8-dimethoxyflavanone CFN99241 113981-49-0 C17H16O5 = 300.3 5mg QQ客服:2056216494
    7-羟基-5,8-二甲氧基黄烷酮; 7-Hydroxy-5,8-dimethoxyflavanone CFN98910 54377-24-1 C17H16O5 = 300.3 5mg QQ客服:2056216494
    8-羟基-5,7-二甲氧基黄烷酮; 8-Hydroxy-5,7-dimethoxyflavanone CFN95580 201230-40-2 C17H16O5 = 300.3 5mg QQ客服:1457312923
    异柄苣素; 6-羟基-5,7,8 -三甲氧基黄烷酮; Isopedicin CFN97739 4431-42-9 C18H18O6 = 330.34 5mg QQ客服:215959384
    7-羟基黄烷酮; 7-Hydroxyflavanone CFN94487 6515-36-2 C15H12O3 = 240.26 20mg QQ客服:2056216494
    松属素; 乔松素; Pinocembrin CFN98740 480-39-7 C15H12O4 = 256.3 20mg QQ客服:1413575084
    7-乙酸-5,7-二羟基二氢黄酮酯; Pinocembrin 7-acetate CFN99096 109592-60-1 C17H14O5 = 298.3 5mg QQ客服:1413575084

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