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  • 松茋

    Pinostilbene

    松茋
    产品编号 CFN98662
    CAS编号 42438-89-1
    分子式 = 分子量 C15H14O3 = 242.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The seeds of Vitis riparia.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    松茋 CFN98662 42438-89-1 1mg QQ客服:1148253675
    松茋 CFN98662 42438-89-1 5mg QQ客服:1148253675
    松茋 CFN98662 42438-89-1 10mg QQ客服:1148253675
    松茋 CFN98662 42438-89-1 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kyushu University (Japan)
  • Universit?t Basel (Switzerland)
  • Mahatma Gandhi University (India)
  • Osmania University (India)
  • Charles Sturt University (Denmark)
  • Sapienza University of Rome (Italy)
  • Ain Shams University (Egypt)
  • The Institute of Cancer Research (United Kingdom)
  • Weizmann Institute of Science (Israel)
  • Universidade do Porto (Portugal)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • University Medical Center Mainz (Germany)
  • Celltrion Chemical Research Institute (Korea)
  • Lodz University of Technology (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • US20170000760 A12016, 42740
  • Int J Oncol.2016, 49(4):1497-504
  • Oncotarget.2016, 8(51):88386-88400
  • BMC Complement Altern Med.2017, 17(1):393
  • International. J. of Food Properties 2017, 20:S131-S140
  • Cytotechnology.2017, 69(5):765-773
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Int J Mol Sci.2018, 19(9):E2601
  • Molecules.2018, 23(2)
  • Molecules.2018, 23(7):E1659
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Phytomedicine.2018, 47:48-57
  • Sci Rep.2018, 8(1):12970
  • Front Pharmacol.2018, 9:236
  • J Ethnopharmacol.2019, 241:112025
  • Food Chem.2019, 278:683-691
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • The Korea Journal of Herbology2019, 34(2):25-32
  • J Sep Sci.2019, 42(21):3352-3362
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Food Analytical Methods2020, 1-10
  • J Ethnopharmacol.2020, 249:112396
  • Evid-Based Compl Alt2020, 7202519:13
  • ...
  • 生物活性
    Description: Pinostilbene has protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells, it can reduce release of lactate dehydrogenase and activity of caspase-3 triggered by 6-hydroxydopamine (6-OHDA) in a dose-dependent manner. Pinostilbene can significantly inhibit the growth of human colon cancer cells, i.e., HCT116 and HT29, 20 and 40 uM of pinostilbene causes cell cycle arrest at S phase and induces apoptosis in colon cancer cells.
    Targets: Caspase | JNK
    In vitro:
    J Nutr Biochem. 2010 Jun;21(6):482-9.
    Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.[Pubmed: 19443200]
    Release of lactate dehydrogenase and activity of caspase-3 triggered by 6-OHDA were significantly reduced by resveratrol and one of the methylated derivatives, Pinostilbene (3,4'-dihydroxy-5-methoxystilbene), in a dose-dependent manner. In addition, Pinostilbene exerted a potent neuroprotective effect with a wider effective concentration range than resveratrol.
    METHODS AND RESULTS:
    By using high-performance liquid chromatography, we found that uptake of Pinostilbene into SH-SY5Y cells was significantly higher than that of resveratrol. Enhanced bioavailability may thus be a major factor contributing to the neuroprotective activity of Pinostilbene. Moreover, Western blot analysis demonstrated that Pinostilbene markedly attenuated the phosphorylation of JNK and c-Jun triggered by 6-OHDA. Besides, mammalian target of rapamycin kinase may be an intracellular target accounting for the neuroprotective effects of Pinostilbene.
    CONCLUSIONS:
    Our findings demonstrate the potential of methylated stilbenes in neuroprotection and provide important information for further research in this field.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1271 mL 20.6356 mL 41.2712 mL 82.5423 mL 103.1779 mL
    5 mM 0.8254 mL 4.1271 mL 8.2542 mL 16.5085 mL 20.6356 mL
    10 mM 0.4127 mL 2.0636 mL 4.1271 mL 8.2542 mL 10.3178 mL
    50 mM 0.0825 mL 0.4127 mL 0.8254 mL 1.6508 mL 2.0636 mL
    100 mM 0.0413 mL 0.2064 mL 0.4127 mL 0.8254 mL 1.0318 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    松茋; Pinostilbene CFN98662 42438-89-1 C15H14O3 = 242.3 5mg QQ客服:2159513211
    Pinostilbenoside; Pinostilbenoside CFN98995 58762-96-2 C21H24O8 = 404.4 5mg QQ客服:3257982914
    3-羟基-5-甲氧基二苯乙烯; 5-Methoxy-3-stilbenol CFN92587 5150-38-9 C15H14O2 = 226.3 5mg QQ客服:2932563308
    Thunalbene; Thunalbene CFN92783 220862-05-5 C15H14O3 = 242.3 5mg QQ客服:1413575084
    3'-O-甲基山药素III; 3'-O-Methylbatatasin III CFN91176 101330-69-2 C16H18O3 = 258.3 5mg QQ客服:2159513211
    Batatasin III; Batatasin III CFN92689 56684-87-8 C15H16O3 = 244.3 5mg QQ客服:3257982914
    3-甲氧基-5-[2-(2-甲氧基苯基)乙基]苯酚; Stilbostemin N CFN97863 1000676-45-8 C16H18O3 = 258.32 5mg QQ客服:2159513211
    紫檀芪; Pterostilbene CFN90397 537-42-8 C16H16O3 = 256.30 20mg QQ客服:2932563308
    3-羟基-4',5-二甲氧基二苯乙烯; 3-Hydroxy-4',5-dimethoxystilbene CFN95199 58436-29-6 C16H16O3 = 256.3 10mg QQ客服:2159513211
    白藜芦醇三甲醚; Trimethoxystilbene CFN90874 22255-22-7 C17H18O3 = 270.3 20mg QQ客服:1148253675

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