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  • 茴芹内酯

    Pimpinellin

    茴芹内酯
    产品编号 CFN99402
    CAS编号 131-12-4
    分子式 = 分子量 C13H10O5 = 246.2
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Coumarins
    植物来源 The fruits of Psoralea corylifolia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    茴芹内酯 CFN99402 131-12-4 10mg QQ客服:1413575084
    茴芹内酯 CFN99402 131-12-4 20mg QQ客服:1413575084
    茴芹内酯 CFN99402 131-12-4 50mg QQ客服:1413575084
    茴芹内酯 CFN99402 131-12-4 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Sao Paulo (Brazil)
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  • University of Lodz (Poland)
  • University of Perugia (Italy)
  • Monash University Malaysia (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean Journal of Pharmacognosy2014, 113-120
  • The Korea Society of Pha.2014, 300-314
  • Phytomedicine.2015, 22(4):498-503
  • Mediators Inflamm.2016, 2016:7216912
  • Korean Herb. Med. Inf. 2016, 4(1):35-42
  • Am J Chin Med.2016, 44(6):1255-1271
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • J Ethnopharmacol.2017, 206:327-336
  • J Bone Miner Res.2017, 32(12):2415-2430
  • Journal of functional foods2018, 171-182
  • Food Quality and Safety2018, 2:213-219
  • Phytomedicine.2018, 38:45-56
  • J of the Society of Cosmetic Scientists of Korea2018, 44(4):407-417
  • Planta Med.2018, 84(6-07):465-474
  • Front Immunol.2018, 9:2655
  • Drug Invention Today2019, 12(6):1303-1306
  • J of Physics Conference Series2019, 1349(1)
  • Environ Toxicol.2019, 34(12):1354-1362
  • Int J Oncol.2019, 55(1):320-330
  • Cell Mol Biol(Noisy-le-grand)2019, 65(7):77-83
  • Biomolecules.2020, 10(2):E184
  • Front Plant Sci.2020, 10:1705
  • Neurochem Int.2020, 133:104629
  • ...
  • 生物活性
    Description: Pimpinellin has phototoxic, it acts as antagonist of proteins with GABA receptor activity. Pimpinellin has anti- inflammatory, and cytotoxic activities. Pimpinellin also has anti-bacterial activity, it shows inhibitory activity against Mycobacterium tuberculosis strain H37Ra , with MICs of 812 uM and IC50s of 389 uM.
    Targets: Antifection
    In vitro:
    J Ethnopharmacol. 2013 May 2;147(1):232-7.
    The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins.[Pubmed: 23501157]
    Heracleum maximum is amongst the most commonly used plants by the indigenous peoples of North America. The First Nations of the eastern Canada use infusions of Heracleum maximum roots for the treatment of respiratory ailments including tuberculosis. Previous investigations of extracts derived from the roots of Heracleum maximum have shown it to possess antimycobacterial activity. To isolate and identify antimycobacterial constituents from the roots of Heracleum maximum.
    METHODS AND RESULTS:
    A methanolic extract of Heracleum maximum roots was subjected to bioassay guided fractionation using the microplate resazurin assay (MRA) to assess inhibitory activity against Mycobacterium tuberculosis strain H37Ra. The antimycobacterial constituents were identified by NMR, MS and polarimetry. The polyacetylene (3R,8S)-falcarindiol and the furanocoumarins bergapten, isobergapten, angelicin, sphondin, pimpinellin, isopimpinellin and 6-isopentenyloxyisobergapten were isolated from the Heracleum maximum root extract. (3R,8S)-Falcarindiol and 6-isopentenyloxyisobergapten exhibited MICs of 24 μM and 167 μM and IC50s of 6 μM and 27 μM against Mycobacterium tuberculosis H37Ra respectively. The remaining furanocoumarins bergapten, isobergapten, angelicin, sphondin, pimpinellin, and isopimpinellin were less active, with MICs of 925, 1850, 2149, 1859, 812 and 1625 μM and IC50s of 125, 344, 350, 351, 389 and 406 μM.
    CONCLUSIONS:
    (3R,8S)-Falcarindiol, bergapten, isobergapten, angelicin, sphondin, pimpinellin, isopimpinellin and 6-isopentenyloxyisobergapten were identified as the principal constituents responsible for the antimycobacterial activity of the roots of Heracleum maximum. This work supports the ethnopharmacological use of Heracleum maximum by Canadian First Nations and Native American communities as a treatment for infectious diseases, specifically tuberculosis.
    In vivo:
    J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Apr 1;891-892:102-8.
    Simultaneous determination of pimpinellin, isopimpinellin and phellopterin in rat plasma by a validated UPLC-MS/MS and its application to a pharmacokinetic study after administration of Toddalia asiatica extract.[Pubmed: 22418072]

    METHODS AND RESULTS:
    A rapid and selective ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for simultaneous determination of three bioactive coumarins of Toddalia asiatica extract including pimpinellin, isopimpinellin and phellopterin in rat plasma for the first time. Phenacetin was used as the internal standard (IS). Plasma samples were extracted by liquid-liquid extraction with methyl tert-butyl ether. The chromatographic separation was carried out on an ACQUITY UPLC™ BEH C₁₈ column with an isocratic mobile phase consisting of methanol-5 mmol/L ammonium acetate (65:35, v/v). The detection was performed on a triple quadrupole tandem mass spectrometer by multiple reaction monitoring (MRM) via electrospray ionization (ESI) source with positive ionization mode. The method was linear for all analytes over investigated range with all correlation coefficients greater than 0.9942. The lower limits of quantification (LLOQ) were 25.0 ng/mL for pimpinellin, 10.0 ng/mL for isopimpinellin and 5.00 ng/mL for phellopterin. The intra- and inter-day precision (RSD%) was within 12% and the accuracy (RE%) ranged from -2.3% to 5.5%.
    CONCLUSIONS:
    The rapid and sensitive method was fully validated and successfully applied to the pharmacokinetic study of pimpinellin, isopimpinellin and phellopterin in rats following oral administration of Toddalia asiatica extract.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0617 mL 20.3087 mL 40.6174 mL 81.2348 mL 101.5435 mL
    5 mM 0.8123 mL 4.0617 mL 8.1235 mL 16.247 mL 20.3087 mL
    10 mM 0.4062 mL 2.0309 mL 4.0617 mL 8.1235 mL 10.1543 mL
    50 mM 0.0812 mL 0.4062 mL 0.8123 mL 1.6247 mL 2.0309 mL
    100 mM 0.0406 mL 0.2031 mL 0.4062 mL 0.8123 mL 1.0154 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异补骨脂素; Angelicin CFN98854 523-50-2 C11H6O3 = 186.2 20mg QQ客服:3257982914
    6-甲氧基当归素; Sphondin CFN98763 483-66-9 C12H8O4 = 216.2 5mg QQ客服:2159513211
    异佛手柑内酯; Isobergapten CFN90231 482-48-4 C12H8O4 = 216.19 20mg QQ客服:1413575084
    茴芹内酯; Pimpinellin CFN99402 131-12-4 C13H10O5 = 246.2 20mg QQ客服:215959384
    Moellendorffilin; Moellendorffilin CFN92638 105099-87-4 C26H20O10 = 492.4 5mg QQ客服:1148253675

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