胡黄连苷IV

Picroside IV

	产品编号	CFN90868
	CAS编号	211567-04-3
	分子式 = 分子量	C₂₄H₂₈O₁₂ = 508.50
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Iridoids
	植物来源	The roots of Picrorhiza scrophulariiflora
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
胡黄连苷IV	CFN90868	211567-04-3	1mg	QQ客服：2056216494
胡黄连苷IV	CFN90868	211567-04-3	5mg	QQ客服：2056216494
胡黄连苷IV	CFN90868	211567-04-3	10mg	QQ客服：2056216494
胡黄连苷IV	CFN90868	211567-04-3	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Tohoku University (Japan)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

Universidade de Franca (Brazil)

University of Toulouse (France)

Heinrich-Heine-University Düsseldorf (Germany)

University of Virginia (USA)

Max Rubner-Institut (MRI) (Germany)

Guangzhou Institutes of Biomedicine and Health (China)

University of Minnesota (USA)

Periyar University (India)

University of Malaya (Malaysia)

Colorado State University (USA)

Research Unit Molecular Epigenetics (MEG) (Germany)

Donald Danforth Plant Science Center (USA)

More...

Description:

Kutkoside is a mixture of iridoid glycosides namely, picroside II, Picroside IV and 6-ferulloylcatalpol, it may have antinociceptive and anti-inflammatory effects.

In vitro:

Indian J Exp Biol. 2010 Mar;48(3):323-8.

Online HPLC-DPPH method for antioxidant activity of Picrorhiza kurroa Royle ex Benth. and characterization of kutkoside by ultra-performance LC-electrospray ionization quadrupole time-of-flight mass spectrometry.[Pubmed: 21046989]

Picrorhiza kurroa Royle ex Benth., is widely used in the Indian systems of medicine for the treatment of various liver ailments.
METHODS AND RESULTS:
Since, the role of oxidative stress in the pathogenesis of liver injury has become generally recognized, in present study the free radical scavenging effect of P. kurroa was assessed by on-line HPLC-DPPH and colorimetric DPPH methods. The comparative study on antioxidant activity of P. kurroa extracts by both methods revealed that colorimetric method showed very less free radical scavenging effect while HPLC-DPPH method showed high activity. Further, the kutkoside, an important ingredient of a potent hepatoprotective formulation "kutkin/picroliv" was investigated for its chemical composition by ultra-performance liquid chromatography coupled with diode array detection/electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-DAD/ESI-QTOF-MS).
CONCLUSIONS:
Kutkoside was considered to be a single compound and reported as picroside-II or kutkoside, however, present investigation illustrated that kutkoside is a mixture of iridoid glycosides namely, picroside II, picroside IV and 6-ferulloylcatalpol.

In vivo:

Z Naturforsch C. 2007 Nov-Dec;62(11-12):813-20.

Antinociceptive and anti-inflammatory effects of saponin and iridoid glycosides from Verbascum pterocalycinum var. mutense Hub.-Mor.[Pubmed: 18274283]

The anti-inflammatory and antinociceptive properties of four major compounds from the flowers of Verbascum pterocalycinum var. mutense were investigated. Saponin glycosides called ilwensisaponin A and C and iridoid glycosides known as ajugol and picroside IV were isolated from the methanolic extract.
METHODS AND RESULTS:
A dose-related anti-inflammatory and antinociceptive response were obtained in this study at doses of 100 and 200 mg/kg. The results of the evaluation of the anti-inflammatory activity induced by carrageenan and PGE1 showed that this species possesses active constituents that could diminish the cyclooxygenase activitiy. No effects were observed in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema model.
CONCLUSIONS:
Our results support the anti-inflammatory and analgesic effects of Verbascum pterocalycinum var. mutense. Ilwensisaponins A and C could explain in part the anti-inflammatory and analgesic activities of this species. Although antinociceptive and anti-inflammatory activities of ajugol and picroside IV were found insignificant in the statistical analysis, ilwensisaponin A and C showed notable activity without inducing any apparent acute toxicity as well as gastric damage.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
6-O-肉桂酰梓醇; 6-O-Cinnamoylcatalpol	CFN99428	136807-41-5	C₂₄H₂₈O₁₁ = 492.5	5mg	QQ客服：215959384
胡黄连苷I; Picroside I	CFN99565	27409-30-9	C₂₄H₂₈O₁₁ = 492.47	20mg	QQ客服：1413575084
黄金树苷; Specioside	CFN97207	72514-90-0	C₂₄H₂₈O₁₂ = 508.5	5mg	QQ客服：215959384
6-O-对甲氧基肉桂酰梓醇; 6-O-p-Methoxycinnamoylcatalpol	CFN99335	121710-02-9	C₂₅H₃₀O₁₂ = 522.5	5mg	QQ客服：1457312923
梓醇6-咖啡酸酯; Verminoside	CFN98809	50932-19-9	C₂₄H₂₈O₁₃ = 524.5	5mg	QQ客服：2056216494
6-阿魏酰梓醇; 6-Feruloylcatalpol	CFN97255	770721-33-0	C₂₅H₃₀O₁₃ = 538.5	5mg	QQ客服：1413575084
米内苷; Minecoside	CFN98811	51005-44-8	C₂₅H₃₀O₁₃ = 538.5	5mg	QQ客服：1457312923
6-O-(3'',4''-二甲氧基肉桂酰)梓醇; 6-O-(3'',4''-Dimethoxycinnamoyl)catalpol	CFN99611	147714-71-4	C₂₆H₃₂O₁₃ = 552.5	5mg	QQ客服：1413575084
胡黄连苷IV; Picroside IV	CFN90868	211567-04-3	C₂₄H₂₈O₁₂ = 508.50	10mg	QQ客服：1413575084
胡黄连苷III; Picroside III	CFN99567	64461-95-6	C₂₅H₃₀O₁₃ = 538.50	20mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9666 mL	9.8328 mL	19.6657 mL	39.3314 mL	49.1642 mL
5 mM	0.3933 mL	1.9666 mL	3.9331 mL	7.8663 mL	9.8328 mL
10 mM	0.1967 mL	0.9833 mL	1.9666 mL	3.9331 mL	4.9164 mL
50 mM	0.0393 mL	0.1967 mL	0.3933 mL	0.7866 mL	0.9833 mL
100 mM	0.0197 mL	0.0983 mL	0.1967 mL	0.3933 mL	0.4916 mL

胡黄连苷IV

Picroside IV

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