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  • 白皮杉醇; 比杉特醇

    Piceatannol

    白皮杉醇; 比杉特醇
    产品编号 CFN99024
    CAS编号 10083-24-6
    分子式 = 分子量 C14H12O4 = 244.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The rhizomes of Polygonum cuspidatum Sieb. et Zucc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    白皮杉醇; 比杉特醇 CFN99024 10083-24-6 10mg QQ客服:2159513211
    白皮杉醇; 比杉特醇 CFN99024 10083-24-6 20mg QQ客服:2159513211
    白皮杉醇; 比杉特醇 CFN99024 10083-24-6 50mg QQ客服:2159513211
    白皮杉醇; 比杉特醇 CFN99024 10083-24-6 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • FORTH-IMBB (Greece)
  • University of Fribourg (Switzerland)
  • Sant Gadge Baba Amravati University (India)
  • Charles University in Prague (Czech Republic)
  • Wroclaw Medical University (Poland)
  • Periyar University (India)
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  • Deutsches Krebsforschungszentrum (Germany)
  • Agricultural Research Organization (ARO) (Israel)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Evid Based Complement Alternat Med.2021, 2021:8707280.
  • J Nat Med.2017, 71(2):457-462
  • New Journal of Chemistry2019, 43:12538-12547
  • Front Microbiol.2021, 12:736780.
  • Planta Med.2022, 88(9-10):794-804.
  • Revista Brasileira de Farmacognosia2021, 31:794-804.
  • PLoS One.2021, 16(9):e0257243.
  • Int J Mol Sci.2020, 21(9):3144.
  • Molecules2022, 27(9):2827.
  • Research Square2021, 10.21203.
  • Nutrients2023, 15(18), 4016.
  • Korean J Dent Mater.2018, 45(2):139-146
  • J Agric Food Chem.2020, 68(51):15164-15175
  • ACS Synth Biol.2022, 11(10):3296-3304.
  • LWT2020, 126:109313
  • Biofactors.2018, 44(2):168-179
  • Nat Chem Biol.2018, 14(8):760-763
  • Neurochem Int.2020, 133:104629
  • Vet World.2023, 16(3):618-630.
  • J Cell Mol Med.2018, 22(9):4236-4242
  • Pharmaceutics.2022, 14(12):2765.
  • J Appl Pharm Sci.2022, 12(04):044-053
  • Archives of Biological sciences2022, 00:21-21
  • ...
  • 生物活性
    Description: Piceatannol has antitumor, antioxidant, and anti-inflammatory activities, it also has the potential to control obesity. Piceatannol inhibits effector T cell functions by suppressing TcR signaling.
    Targets: IL Receptor | ERK | Akt | p38MAPK | gp120/CD4
    In vitro:
    Int Immunopharmacol. 2015 Feb 9;25(2):285-292.
    Piceatannol inhibits effector T cell functions by suppressing TcR signaling.[Pubmed: 25676533]
    Piceatannol, a metabolite of resveratrol found in red wine and grapes, displays a wide spectrum of biological activity. Although the anti-oxidant, anti-inflammatory, and anti-tumorigenesis activity of piceatannol has been extensively studied, its role in the adaptive immune response has received less attention.
    METHODS AND RESULTS:
    Here we investigated the role of piceatannol, a well-known Syk inhibitor, in T cell activation, proliferation, and differentiation using isolated murine splenic T cells from C57BL/6 mice. Piceatannol treatment inhibited surface expression of CD4 and CD8 T cell activation markers CD25 and CD69, reduced production of cytokines IFNγ, IL-2, and IL-17, and suppressed proliferation of activated T cells. Moreover, piceatannol treatment significantly inhibited differentiation of CD4(+)CD25(-)CD62L(+) naïve CD4 T cells into Th1, Th2, and Th17 cells, presumably due to inhibition of TcR signaling through p-Erk, p-Akt, and p-p38.
    CONCLUSIONS:
    Piceatannol appears to be a useful nutritional or pharmacological biomolecule that regulates effector T cell functions such as cytokine production, differentiation, and proliferation.
    Phytother Res. 2014 Nov;28(11):1581-8.
    A review of the pharmacological effects of piceatannol on cardiovascular diseases.[Pubmed: 24919577]
    The incidence of cardiovascular diseases (CVDs) is high in both developed and developing countries. It has a high global rate of mortality and causes heavy social burden. Drugs are available for managing or treating CVDs and its complications. Consumption of dietary supplements or functional foods for reducing the risk of CVDs has also gained wide recognition by the general public.
    METHODS AND RESULTS:
    Piceatannol, an analog and metabolite of resveratrol, is a natural stilbene commonly found in the skin of grapes and wine. Piceatannol is believed to be a potent compound with certain cardiovascular therapeutic effects, such as the prevention of hypercholesterolemia, arrhythmia, atherosclerosis, and angiogenesis. It also has vasorelaxation and antioxidant activities.
    CONCLUSIONS:
    A comprehensive review of piceatannol concludes that piceatannol has the potential to be developed into health products for the cardiovascular system to help modern society reduce the high CVD incidence. However, further investigations are warranted in order to increase the bioavailability and understand the biological mechanisms and safety of using piceatannol.
    J Med Food . 2017 May;20(5):427-438.
    The Therapeutic Potential of Piceatannol, a Natural Stilbene, in Metabolic Diseases: A Review[Pubmed: 28387565]
    Abstract Metabolic disease comprises a set of risk factors highly associated with obesity and insulin resistance and is a consequence of central adiposity, hyperglycemia, and dyslipidemia. Furthermore, obesity increases the risk of the development of metabolic disease due to ectopic fat deposition, low-grade inflammation, and systemic energy disorders caused by dysregulated adipose tissue function. Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and has been reported to exhibit anticancer and anti-inflammatory properties. In addition, recently reported beneficial effects of piceatannol on hypercholesterolemia, atherosclerosis, and angiogenesis underscore its therapeutic potential in cardiovascular disease. However, investigation of its role in metabolic disease is still in its infancy. This review intensively summarizes in vitro and in vivo studies supporting the potential therapeutic effects of piceatannol in metabolic disease, including inhibition of adipogenesis and lipid metabolism in adipocytes, and regulation of hyperlipidemia, hyperglycemia, insulin resistance, and fatty acid-induced inflammation and oxidative stress. Keywords: adipocytes; adipose tissue; bioavailability; insulin resistance; obesity; resveratrol.
    In vivo:
    Front Pharmacol . 2020 Jan 22;10:1613.
    Protective Effect of Piceatannol Against Acute Lung Injury Through Protecting the Integrity of Air-Blood Barrier and Modulating the TLR4/NF-κB Signaling Pathway Activation[Pubmed: 32038265]
    Abstract Acute lung injury (ALI) is a common and complex inflammatory lung syndrome with higher morbidity and mortality rate. Piceatannol (PIC) has anti-inflammation and anti-oxidant properties. The study was designed to explore the effect and the action mechanisms of PIC on lipopolysaccharide (LPS)-induced ALI. Twenty-four hours after LPS challenge, mice from different treatment groups were euthanized, and the bronchoalveolar lavage fluid (BALF) and lung tissue samples were collected. Then the degree of pulmonary edema, lung pathological changes, myeloperoxidase (MPO) activity, and the production of pro-inflammatory cytokines were detected. Additionally, the messenger RNA (mRNA) expressions associated with cell adhesion molecules and tight junction were analyzed through quantitative real-time (qRT)-PCR, and the TLR4/NF-κB activation was examined by western blot. The results showed that PIC significantly inhibited LPS-induced lung edema, histopathological damage, MPO activity, cell infiltration, and pro-inflammatory cytokines production. Moreover, PIC notably suppressed mRNA expressions associated with inflammation and cell adhesion molecules. Furthermore, PIC also alleviated LPS-induced damage of air-blood barrier through reducing the levels of total proteins in BALF and recovering the expression of occludin and ZO-1 in the lung tissues. We also found that PIC remarkably restrained the LPS-induced TLR4/NF-κB pathway activation in lung tissues. In conclusion, PIC may be potential to treat LPS-induced acute lung injury (ALI) via regulating air-blood barrier and TLR4/NF-κB signaling pathway activation. Keywords: TLR4/NF-κB; acute lung injury; air-blood barrier; lipopolysaccharide; piceatannol.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.095 mL 20.475 mL 40.95 mL 81.9001 mL 102.3751 mL
    5 mM 0.819 mL 4.095 mL 8.19 mL 16.38 mL 20.475 mL
    10 mM 0.4095 mL 2.0475 mL 4.095 mL 8.19 mL 10.2375 mL
    50 mM 0.0819 mL 0.4095 mL 0.819 mL 1.638 mL 2.0475 mL
    100 mM 0.041 mL 0.2048 mL 0.4095 mL 0.819 mL 1.0238 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    氧化白藜芦醇-2-O-D-吡喃葡萄糖苷; Oxyresveratrol 2-O-beta-D-glucopyranoside CFN90789 392274-22-5 C20H22O9 = 406.4 5mg QQ客服:2056216494
    氧化白藜芦醇-3'-O-β-D-吡喃葡萄糖苷; Oxyresveratrol 3'-O-beta-D-glucopyranoside CFN90793 144525-40-6 C20H22O9 = 406.4 5mg QQ客服:1457312923
    桑皮苷A; Mulberroside A CFN99586 102841-42-9 C26H32O14 = 568.52 20mg QQ客服:3257982914
    cis-桑皮苷A; cis-Mulberroside A CFN95006 166734-06-1 C26H32O14 = 568.52 10mg QQ客服:1457312923
    Gnetucleistol D; Gnetucleistol D CFN92443 629643-26-1 C15H14O4 = 258.3 5mg QQ客服:3257982914
    买麻藤醇; Gnetol CFN92425 86361-55-9 C14H12O4 = 244.2 20mg QQ客服:2056216494
    Gnetucleistol B; Gnetucleistol B CFN92678 864763-60-0 C15H14O5 = 274.3 5mg QQ客服:2056216494
    丹酚酸F; Salvianolic acid F CFN90811 158732-59-3 C17H14O6 = 314.3 5mg QQ客服:1413575084
    异丹叶大黄素; Isorhapotogenin CFN92426 32507-66-7 C15H14O4 = 258.3 20mg QQ客服:2159513211
    5-[2-(4-羟基-3-甲氧基苯基)乙基]-1,3-苯二酚; Tristin CFN97824 139101-67-0 C15H16O4 = 260.29 5mg QQ客服:1457312923

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