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  • 叶下珠脂素

    Phyllanthin

    叶下珠脂素
    产品编号 CFN99050
    CAS编号 10351-88-9
    分子式 = 分子量 C24H34O6 = 418.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The herbs of Phyllanthus niruri L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    叶下珠脂素 CFN99050 10351-88-9 1mg QQ客服:215959384
    叶下珠脂素 CFN99050 10351-88-9 5mg QQ客服:215959384
    叶下珠脂素 CFN99050 10351-88-9 10mg QQ客服:215959384
    叶下珠脂素 CFN99050 10351-88-9 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Technical University of Denmark (Denmark)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of Canterbury (New Zealand)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Kazusa DNA Research Institute (Japan)
  • University of Hawaii Cancer Center (USA)
  • Georgia Institute of Technology (USA)
  • Biotech R&D Institute (USA)
  • Srinakharinwirot University (Thailand)
  • Ain Shams University (Egypt)
  • University of Auckland (New Zealand)
  • Universidad Veracuzana (Mexico)
  • Shanghai University of TCM (China)
  • Center for protein Engineering (CIP) (Belgium)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Analytical Methods2020, 1-10
  • BMC Plant Biol.2018, 18(1):122
  • Int J Mol Sci.2020, 21(22):8816.
  • Environ Toxicol.2023, tox.23999.
  • Antimicrob Agents Chemother.2020, AAC.01921-20.
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Biomed Pharmacother.2022, 146:112497.
  • Preprints2022, 2022030063.
  • J Pharm Biomed Anal.2022, 207:114398.
  • Aging (Albany NY).2021, 13(19):22867-22882.
  • Sci Rep.2021, 11(1):10931.
  • Int J Mol Sci.2018, 19(9):E2528
  • Food Funct.2022, 13(23):12105-12120.
  • J Pharm Biomed Anal.2021, 196:113931.
  • Front Cell Dev Biol.2021, 9:764263.
  • Molecules.2020, 25(23):5636.
  • BMC Complement Med Ther. 2020, 20(1):94.
  • Genes (Basel).2021, 12(7):1024.
  • J Sep Sci.2018, 41(11):2488-2497
  • Plants (Basel).2021, 10(5):951.
  • Int J Biol Macromol.2018, 112:1093-1103
  • Indian J. of Experimental Bio.2020, 9(58).
  • Plant Growth Regulation2020, 90(2):383-392
  • ...
  • 生物活性
    Description: Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.
    Targets: NF-kB | TGF-β/Smad | P-gp
    In vitro:
    J Pharm Pharmacol. 2013 Feb;65(2):292-9.
    Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells.[Pubmed: 23278697]
    The purposes of this study were to investigate the inhibitory effects of two lignans, phyllanthin and hypophyllanthin, on the function of P-glycoprotein (P-gp) and multidrug resistance protein 2 (MRP2), using the in-vitro model of Caco-2 cells. In addition, the effect of prolonged exposure to these two compounds on the expression of active P-gp was also determined.
    METHODS AND RESULTS:
    The activity of P-gp and MRP2 was determined in the uptake assays by monitoring the intracellular accumulation of their specific substrates (calcein acetoxymethyl ester and 5(6)-carboxy-2',7'-dichlorofluorescein diacetate, respectively) with fluorescence spectroscopy. Hypophyllanthin and phyllanthin inhibited P-gp function with comparable potencies, but neither compound affected MRP2 activity. When the lignans were washed out before addition of substrate, the inhibitory action of both compounds against P-gp function was lost. These results suggested the reversibility of the inhibition. Moreover, prolonged exposure of the Caco-2 cells to both lignans (up to 7 days) had no effect on P-gp function.
    CONCLUSIONS:
    Phyllanthin and hypophyllanthin directly inhibited P-gp activity and did not interfere with MRP2 activity. It was likely that both phyllanthin and hypophyllanthin could reversibly inhibit P-gp function.
    Chem Biol Interact. 2009 Oct 30;181(3):351-8.
    Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line.[Pubmed: 19576190]
    The present study was an attempt to investigate the hepatoprotective and antioxidative property of Phyllanthus amarus (P. amarus) extract and phyllanthin.
    METHODS AND RESULTS:
    Phyllanthin, one of the active lignin present in this plant species was isolated from the aerial parts, by silica gel column chromatography employing gradient elution with hexane-ethyl acetate solvent mixture. It was obtained in high yields (1.23%), compared to reported procedures and the purity was ascertained by HPTLC and reversed-phase HPLC analysis. Characterization of phyllanthin was done by mp, UV-Visible spectrophotometry, elemental analysis, FT-IR, 1H NMR, 13C NMR and mass spectral analysis. Free radical scavenging activity of P. amarus extract and phyllanthin was also examined using DPPH assay. The protective effect of P. amarus extract and phyllanthin was studied on CCl4-induced toxicity in human hepatoma HepG2 cell line.
    CONCLUSIONS:
    The results indicated that CCl4 treatment caused a significant decrease in cell viability. In addition, the toxin treatment initiated lipid peroxidation (LPO), caused leakage of enzymes like alanine transaminase (ALT) and lactate dehydrogenase (LDH) with a significant decrease in glutathione (GSH) levels. It was observed that phyllanthin effectively alleviated the changes induced by CCl4 in a concentration-dependent manner, with much smaller strengths as compared to P. amarus extract.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3895 mL 11.9474 mL 23.8949 mL 47.7897 mL 59.7372 mL
    5 mM 0.4779 mL 2.3895 mL 4.779 mL 9.5579 mL 11.9474 mL
    10 mM 0.2389 mL 1.1947 mL 2.3895 mL 4.779 mL 5.9737 mL
    50 mM 0.0478 mL 0.2389 mL 0.4779 mL 0.9558 mL 1.1947 mL
    100 mM 0.0239 mL 0.1195 mL 0.2389 mL 0.4779 mL 0.5974 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Arisanschinin E; Arisanschinin E CFN95221 1333378-33-8 C21H28O5 = 360.5 5mg QQ客服:215959384
    前五味子脂素; Pregomisin CFN96694 66280-26-0 C22H30O6 = 390.47 10mg QQ客服:2056216494
    脱水开环异落叶松树脂酚; Anhydrosecoisolariciresinol CFN89236 29388-33-8 C20H24O5 = 344.40 5mg QQ客服:1413575084
    4,4'-[[(2S,3S,4S)-四氢-2-甲氧基-3,4-呋喃二基]二(亚甲基)]二[2-甲氧基苯酚]; 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan CFN96711 1206464-65-4 C21H26O6 = 374.43 5mg QQ客服:215959384
    开环异落叶松树脂酚; Secoisolariciresinol CFN98363 29388-59-8 C20H26O6 = 362.4 10mg QQ客服:2056216494
    开环异落叶松树脂素一苷; Secoisolariciresinol monoglucoside CFN96682 63320-67-2 C26H36O11 = 524.56 5mg QQ客服:215959384
    亚麻木酚素; Secoisolariciresinol Diglucoside CFN99722 148244-82-0 C32H46O16 = 686.71 20mg QQ客服:215959384
    开环异落叶松树脂酚 9,9'-二乙酸酯; Secoisolariciresinol 9,9'-diacetate CFN95601 848844-79-1 C24H30O8 = 446.5 5mg QQ客服:1413575084
    9,9'-二-O-(E)-阿魏酰开环异落叶松脂素; 9,9'-Di-O-(E)-feruloylsecoisolariciresinol CFN98956 56973-66-1 C40H42O12 = 714.8 5mg QQ客服:2159513211
    5,5'-二甲氧基开环异落叶松树脂酚; 5,5'-Dimethoxysecoisolariciresinol CFN92963 1002106-91-3 C22H30O8 = 422.47 5mg QQ客服:1457312923

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