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  • 氯化天竺葵素

    Pelargonidin chloride

    氯化天竺葵素
    产品编号 CFN92132
    CAS编号 134-04-3
    分子式 = 分子量 C15H11O5Cl = 306.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Vaccinium myrtillus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    氯化天竺葵素 CFN92132 134-04-3 1mg QQ客服:1413575084
    氯化天竺葵素 CFN92132 134-04-3 5mg QQ客服:1413575084
    氯化天竺葵素 CFN92132 134-04-3 10mg QQ客服:1413575084
    氯化天竺葵素 CFN92132 134-04-3 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Católica Portuguesa (Portugal)
  • University of Padjajaran (Indonesia)
  • University of Canterbury (New Zealand)
  • Utah State University (USA)
  • University of Vigo (Spain)
  • University of Melbourne (Australia)
  • University of South Australia (Australia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Cancers (Basel).2023, 15(1):293.
  • Molecules.2020, 25(23):5609.
  • Int J Biol Macromol.2021, 199:189-200.
  • Biomolecules.2021, 11(10):1537.
  • Free Radic Biol Med.2017, 112:191-199
  • Current Topics in Nutraceutical Research2021, 19(1),p90-105.
  • BMB Rep.2020, 53(4):218-222.
  • Antioxidants (Basel).2022, 11(12):2327.
  • Molecules.2016, 21(6)
  • Oncotarget.2015, 6(31):30831-49
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • Natural Product Communications2020, doi: 10.1177.
  • Antioxidants (Basel).2020, 9(2):E99
  • Regul Toxicol Pharmacol.2023, 142:105433.
  • J Pharmaceut Biomed2020, 178:112894
  • Front Aging Neurosci.2018, 10:269
  • Mie University2019, 10076.
  • Sci Rep. 2018, 462(8)
  • FEBS Lett.2021, 595(20):2608-2615.
  • J Nat Med.2022, 76(1):59-67.
  • Chung Shan Medical University2020, US20200323790A1
  • Sustainability2021, 13(23),12981.
  • Molecules.2020, 25(3):734
  • ...
  • 生物活性
    Description: Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 signaling pathway. It also has the antianaphylactic properties, which might be related to the increase of both cyclic AMP and cyclic GMP through the inhibition of phosphodiesterase. Pelargonidin chloride has strong antioxidative activity in a liposomal system and reduced the formation of malondialdehyde by UVB irradiation.
    Targets: NO | NOS | Keap1 | Nrf2 | cAMP | cGMP
    In vitro:
    Frontiers in Pharmacology, 2017, 8:868.
    Pelargonidin Modulates Keap1/Nrf2 Pathway Gene Expression and Ameliorates Citrinin-Induced Oxidative Stress in HepG2 Cells.[Reference: WebLink]
    Pelargonidin chloride (PC) is one of the major anthocyanin found in berries, radish and other natural foods. Many natural chemopreventive compounds have been shown to be potent inducers of phase II detoxification genes and its up-regulation is important for oxidative stress related disorders.
    METHODS AND RESULTS:
    In the present study, we investigated the effect of PC in ameliorating citrinin (CTN) induced cytotoxicity and oxidative stress. The cytotoxicity of CTN was evaluated by treating HepG2 (Human hepatocellular carcinoma) cells with CTN (0-150 μM) in a dose dependent manner for 24 h, and the IC50 was determined to be 96.16 μM. CTN increased lactate dehydrogenase leakage (59%), elevated reactive oxygen species (2.5-fold), depolarized mitochondrial membrane potential as confirmed by JC-1 monomers and arrested cell cycle at G2/M phase. Further, apoptotic and necrotic analysis revealed significant changes followed by DNA damage. To overcome these toxicological effects, PC was pretreated for 2 h followed by CTN exposure for 24 h. Pretreatment with PC resulted in significant increase in cell viability (84.5%), restored membrane integrity, reactive oxygen species level were maintained and cell cycle phases were normal. PC significantly up-regulated the activity of detoxification enzymes: heme oxygenase 1 (HO-1), glutathione transferase, glutathione peroxidase, superoxide dismutase and quinone reductase. Nrf2 translocation into the nucleus was also observed by immunocytochemistry analysis.
    CONCLUSIONS:
    These data demonstrate the protective effect of PC against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 signaling pathway.
    Biochem Pharmacol, 1996, 52(7):1033-1039.
    Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L.[Reference: WebLink]

    METHODS AND RESULTS:
    No attention has been paid to anthocyanin pigments from the viewpoint of inhibitors of lipid peroxidation and scavengers of active oxygen radicals; therefore, we investigated the antioxidative, radical scavenging, and inhibitory effects on lipid peroxidation by UV light irradiation of three anthocyanin pigments, pelargonidin 3-O-beta-D-glucoside (P3G), cyanidin 3-O-beta-D-glucoside (C3G), and delphinidin 3-O-beta-D-glucoside (D3G), isolated from the Phaseolus vulgaris L. seed coat, and their aglycons, pelargonidin chloride (Pel), cyanidin chloride (Cy), and delphinidin chloride (Del).
    CONCLUSIONS:
    All pigments had strong antioxidative activity in a liposomal system and reduced the formation of malondialdehyde by UVB irradiation. On the other hand, the extent of antioxidative activity in a rat liver microsomal system and the scavenging effect of hydroxyl radicals (-OH) and superoxide anion radicals (O2-) were influenced by their own structures.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2605 mL 16.3026 mL 32.6052 mL 65.2103 mL 81.5129 mL
    5 mM 0.6521 mL 3.2605 mL 6.521 mL 13.0421 mL 16.3026 mL
    10 mM 0.3261 mL 1.6303 mL 3.2605 mL 6.521 mL 8.1513 mL
    50 mM 0.0652 mL 0.3261 mL 0.6521 mL 1.3042 mL 1.6303 mL
    100 mM 0.0326 mL 0.163 mL 0.3261 mL 0.6521 mL 0.8151 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    纹香茶菜E; Lophanthoidin E CFN99318 120462-45-5 C22H30O7 = 406.5 5mg QQ客服:215959384
    3'-甲氧基大豆苷; 3'-Methoxydaidzin CFN89443 200127-80-6 C22H22O10 = 446.40 10mg QQ客服:215959384
    Hydrangenoside A dimethyl acetal; Hydrangenoside A dimethyl acetal CFN97593 952485-00-6 C33H46O14 = 666.72 5mg QQ客服:1413575084
    13(18)-齐墩果烯-3-醇,Α-香树素; 13(18)-Oleanen-3-ol CFN98801 508-04-3 C30H50O = 426.7 5mg QQ客服:1457312923

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