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  • 巴利森苷B

    Parishin B

    巴利森苷B
    产品编号 CFN93113
    CAS编号 174972-79-3
    分子式 = 分子量 C32H40O19 = 728.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The rhizomes of Gastrodia elata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    巴利森苷B CFN93113 174972-79-3 10mg QQ客服:3257982914
    巴利森苷B CFN93113 174972-79-3 20mg QQ客服:3257982914
    巴利森苷B CFN93113 174972-79-3 50mg QQ客服:3257982914
    巴利森苷B CFN93113 174972-79-3 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • University of Dicle (Turkey)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2022, 23(23):14545.
  • Evid Based Complement Alternat Med.2021, 2021:6687513.
  • University of Guelph2021, 12.
  • Nutrients.2022, 14(16):3393.
  • Sci Adv.2018, 4(10)
  • Int J Mol Sci.2021, 22(21):11447.
  • Front Immunol.2017, 8:1542
  • Appl. Sci.2021, 11(24),12080
  • Int Immunopharmacol.2023, 125:111175.
  • Neuropharmacology.2018, 131:68-82
  • Metabolites.2019, 9(11):E271
  • Pharmaceuticals (Basel).2020, 13(10):302.
  • Nutrients.2022, 14(23):4997.
  • J Ethnopharmacol.2019, 235:406-414
  • Natural Product Res.&Deve.2022, 1001-6880.
  • Cell Prolif.2021, 54(8):e13083.
  • Food and Chemical Toxicology2020, 111221
  • Biomed Pharmacother.2019, 111:262-269
  • Spectrochim Acta A2019, 210:372-380
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • Molecules.2019, 24(17):E3127
  • J Separation Science & Technology2016, 51:1579-1588
  • Chemistry of plant raw materials2021, 1:pp 139-150
  • ...
  • 生物活性
    Description: Parishin B has good neuroprotective effects against brain disorders, it can prevent vascular dementia.
    Targets: VEGFR
    In vivo:
    Zhongguo Zhong Yao Za Zhi. 2015 Jul;40(13):2668-73.
    Study on active ingredient and mechanism in preventing vascular dementia of Tianzhusan coming from Tujia medicine.[Pubmed: 26697697]

    METHODS AND RESULTS:
    To make clear of the absorbed components of Tianzhusan (TZS) and its possible mechanism in preventing vascular dementia (VD), the rats' models of VD were prepared by a permanent ligation of the bilateral common carotid arteries. After 60 days, rats were administrated with TZS for 0.1 g x kg(-1), and the volume is 0.02 mL x g(-1). After 3 days, the medicated serum was prepared and detected by UPLC, and then we predicted the possible chemical structure of the absorbed components of TZS. According to the absorbed components, the potential targets of TZS were found by ligand profiling of Discovery Studio 3.5. All of these target genes were submitted to DAVID onine for gene set enrichment analysis (GSEA). The 5 absorbed components of TZS have been predicted, and four of them have been identified as Parishin B, parishin C, parishin, pennogenin-3-O-alpha-L-rhamnopyranosy-(1-->2)-beta-D-glucoside. Through reverse finding targets, we got 861 pharmacophore models and 9 pathways from KEGG, BIOCARTA after document verification.
    CONCLUSIONS:
    These results showed that the efficacy mechanism of TZS on VD perhaps were be related with these absorbed components and pathways. If the traditional herbs could be proved effective by efficacy tests, the serum pharmacochemistry, computer-aided drug design, system biology and other technologies can be used in the next experiments, which will be beneficial to fast discovery of material basis and mechanisms of traditional medicine coming form ethnic minorities.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3723 mL 6.8615 mL 13.7231 mL 27.4461 mL 34.3077 mL
    5 mM 0.2745 mL 1.3723 mL 2.7446 mL 5.4892 mL 6.8615 mL
    10 mM 0.1372 mL 0.6862 mL 1.3723 mL 2.7446 mL 3.4308 mL
    50 mM 0.0274 mL 0.1372 mL 0.2745 mL 0.5489 mL 0.6862 mL
    100 mM 0.0137 mL 0.0686 mL 0.1372 mL 0.2745 mL 0.3431 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    冬绿苷; Gaultherin CFN90338 490-67-5 C19H26O12 = 446.40 5mg QQ客服:3257982914
    红果酸; Eucomic acid CFN95364 42151-32-6 C11H12O6 = 240.2 5mg QQ客服:1457312923
    番石榴酸; Piscidic acid CFN91622 469-65-8 C11H12O7 = 256.21 5mg QQ客服:2056216494
    升麻酸F; Cimicifugic acid F CFN70314 220618-91-7 C21H20O10 = 432.4 5mg QQ客服:2056216494
    升麻酸B; Cimicifugic acid B CFN70303 205114-66-5 C21H20O11 = 448.4 5mg QQ客服:1457312923
    巴利森苷E; Parishin E CFN93115 952068-57-4 C19H24O13 = 460.4 20mg QQ客服:215959384
    巴利森苷G; Parishin G CFN95324 952283-93-1 C19H24O13 = 460.4 10mg QQ客服:3257982914
    巴利森苷B; Parishin B CFN93113 174972-79-3 C32H40O19 = 728.7 20mg QQ客服:1413575084
    巴利森苷C; Parishin C CFN93114 174972-80-6 C32H40O19 = 728.7 20mg QQ客服:2056216494
    巴利森苷A; Parishin A CFN93112 62499-28-9 C45H56O25 = 996.9 20mg QQ客服:2159513211

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