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  • 巴利森苷A

    • 巴利森苷A

    Parishin A

    巴利森苷A
    		产品编号 CFN93112
    CAS编号 62499-28-9
    分子式 = 分子量 C45H56O25 = 996.9
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The rhizomes of Gastrodia elata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    巴利森苷A CFN93112 62499-28-9 10mg QQ客服：215959384
    巴利森苷A CFN93112 62499-28-9 20mg QQ客服：215959384
    巴利森苷A CFN93112 62499-28-9 50mg QQ客服：215959384
    巴利森苷A CFN93112 62499-28-9 100mg QQ客服：215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Charles University in Prague (Czech Republic)
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  • Kamphaengphet Rajabhat University (Thailand)
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  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Industrial Crops and Products2021, 163:113313.
  • Heliyon.2022, 8(12):e12031.
  • Preprints2021, doi:10.20944
  • Nutrients.2021, 13(1):254.
  • Antioxidants (Basel).2022, 11(10):1929.
  • J of Pharmaceutical Analysis2020, doi: 10.1016
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Biomed Pharmacother.2022, 145:112410.
  • Cancers (Basel).2021, 13(9):2223.
  • J of App. Res. on Med&Aromatic Plants2020, 100291.
  • Toxins (Basel).2020, 12(4):210.
  • Journal of Third Military Medical University2019, 41(2):110-115
  • Drug Dev Res.2022, 83(7):1673-1682.
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Food Science and Biotechnology2023, 2023:1007
  • Appl. Sci.2022, 12(4), 2032.
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • Virulence.2018, 9(1):588-603
  • Molecules.2019, 24(24),4583
  • Biomed Chromatogr.2022, 36(11):e5462.
  • Horticulture Research2023, uhad164.
  • Heliyon.2023, e12778.
  • bioRxiv2021, 458409.
  • ...
    • 生物活性
    Description: Parishin A has good neuroprotective effects against brain disorders.
    In vitro:
    Oxid Med Cell Longev . 2016;2016:4074690.
    Parishin from Gastrodia elata Extends the Lifespan of Yeast via Regulation of Sir2/Uth1/TOR Signaling Pathway[Pubmed: 27429709]
    Abstract Parishin is a phenolic glucoside isolated from Gastrodia elata, which is an important traditional Chinese medicine; this glucoside significantly extended the replicative lifespan of K6001 yeast at 3, 10, and 30 μM. To clarify its mechanism of action, assessment of oxidative stress resistance, superoxide dismutase (SOD) activity, malondialdehyde (MDA), and reactive oxygen species (ROS) assays, replicative lifespans of sod1, sod2, uth1, and skn7 yeast mutants, and real-time quantitative PCR (RT-PCR) analysis were conducted. The significant increase of cell survival rate in oxidative stress condition was observed in parishin-treated groups. Silent information regulator 2 (Sir2) gene expression and SOD activity were significantly increased after treating parishin in normal condition. Meanwhile, the levels of ROS and MDA in yeast were significantly decreased. The replicative lifespans of sod1, sod2, uth1, and skn7 mutants of K6001 yeast were not affected by parishin. We also found that parishin could decrease the gene expression of TORC1, ribosomal protein S26A (RPS26A), and ribosomal protein L9A (RPL9A) in the target of rapamycin (TOR) signaling pathway. Gene expression levels of RPS26A and RPL9A in uth1, as well as in uth1, sir2 double mutants, were significantly lower than those of the control group. Besides, TORC1 gene expression in uth1 mutant of K6001 yeast was inhibited significantly. These results suggested that parishin exhibited antiaging effects via regulation of Sir2/Uth1/TOR signaling pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0031 mL 5.0155 mL 10.0311 mL 20.0622 mL 25.0777 mL
    5 mM 0.2006 mL 1.0031 mL 2.0062 mL 4.0124 mL 5.0155 mL
    10 mM 0.1003 mL 0.5016 mL 1.0031 mL 2.0062 mL 2.5078 mL
    50 mM 0.0201 mL 0.1003 mL 0.2006 mL 0.4012 mL 0.5016 mL
    100 mM 0.01 mL 0.0502 mL 0.1003 mL 0.2006 mL 0.2508 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    邻苯二甲酸二甲酯； 避蚊酯; Dimethyl phthalate CFN99401 131-11-3 C10H10O4 = 194.2 20mg QQ客服：3257982914
    绣线菊苷; Helicin CFN70171 618-65-5 C13H16O7 = 284.3 20mg QQ客服：1413575084
    冬绿苷; Gaultherin CFN90338 490-67-5 C19H26O12 = 446.40 5mg QQ客服：215959384
    红果酸; Eucomic acid CFN95364 42151-32-6 C11H12O6 = 240.2 5mg QQ客服：3257982914
    番石榴酸; Piscidic acid CFN91622 469-65-8 C11H12O7 = 256.21 5mg QQ客服：215959384
    升麻酸F; Cimicifugic acid F CFN70314 220618-91-7 C21H20O10 = 432.4 5mg QQ客服：2159513211
    升麻酸B; Cimicifugic acid B CFN70303 205114-66-5 C21H20O11 = 448.4 5mg QQ客服：2056216494
    巴利森苷E; Parishin E CFN93115 952068-57-4 C19H24O13 = 460.4 20mg QQ客服：3257982914
    巴利森苷G; Parishin G CFN95324 952283-93-1 C19H24O13 = 460.4 10mg QQ客服：2056216494
    巴利森苷B; Parishin B CFN93113 174972-79-3 C32H40O19 = 728.7 20mg QQ客服：1413575084

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