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  • 盐酸巴马汀

    Palmatine hydrochloride

    盐酸巴马汀
    产品编号 CFN99124
    CAS编号 10605-02-4
    分子式 = 分子量 C21H22ClNO4 = 387.86
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Alkaloids
    植物来源 The rhizomes of Coptis chinensis Franch.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    盐酸巴马汀 CFN99124 10605-02-4 10mg QQ客服:2159513211
    盐酸巴马汀 CFN99124 10605-02-4 20mg QQ客服:2159513211
    盐酸巴马汀 CFN99124 10605-02-4 50mg QQ客服:2159513211
    盐酸巴马汀 CFN99124 10605-02-4 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of South Australia (Australia)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • University of Minnesota (USA)
  • Semmelweis Unicersity (Hungary)
  • Massachusetts General Hospital (USA)
  • University of Dicle (Turkey)
  • Max Rubner-Institut (MRI) (Germany)
  • Universidad de La Salle (Mexico)
  • Universiti Malaysia Pahang (Malaysia)
  • Celltrion Chemical Research Institute (Korea)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Nicolaus Copernicus Uniwersity (Poland)
  • University of Bordeaux (France)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian Journal of Chemistry2014, 26(8):2425
  • Inflammation2015, 38(1):445-55
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • Mol Pharm.2017, 14(9):3164-3177
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Srinagarind Medical Journal2017, 32(1)
  • Viruses.2017, 9(10)
  • Industrial Crops and Products2017, 95:286-295
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • J Nat Prod.2018, 81(4):966-975
  • Nat Commun.2019, 10(1):2745
  • Plant Physiol Biochem.2019, 144:355-364
  • BMC Microbiol.2019, 19(1):78
  • Int J Mol Sci.2019, 20(11):E2734
  • Aquaculture2019, 510:392-399
  • Phytomedicine.2019, 58:152893
  • Int Immunopharmacol.2019, 71:361-371
  • Saudi Pharm J2020, 10.1016
  • J Pharmaceut Biomed2020, 178:112894
  • United States Patent Application2020, 20200038363
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Biochem Biophys Res Commun.2020, 522(4):1052-1058
  • ...
  • 生物活性
    Description: Palmatine hydrochloride is a hydrochloride salt of palmatine which is a protoberberine alkaloid, it can induce remarkable cell apoptosis, has potential in photodynamic therapy on colon adenocarcinoma. Palmatine hydrochloride has anti-C. albicans effect, it mixes with berberine hydrochloride elicit antifungal activities, it also can reduce blood sugar and oxidative stress in STZ induced diabetic rats.
    Targets: Antifection
    In vitro:
    Acta Chim. Sin. Chinese Edition, 2009, 67(21):2511-6.
    Investigation on the Anti-Candida albicans Effect of Palmatine Hydrochloride Based on Microcalorimetry and Principal Component Analysis[Reference: WebLink]

    METHODS AND RESULTS:
    Using an LKB-2277 bioactivity monitor, the metabolic power-time curves of Candida albicans (C albicans) growth affected by palmatine hydrochloride were measured at 37 degrees C, then nine quantitative thermokinetic parameters were obtained from these curves and investigated by principal component analysis (PCA) to evaluate the anti-C. albicans effect of palmatine hydrochloride. The results showed that the anti-C. albicans effect of this compound was mainly influenced by the growth rate constant (k(2)) and maximum power output P(m)(2) of phase II, and could be easily, quickly and exactly evaluated by analyzing the change of these two quantitative parameters.
    CONCLUSIONS:
    This work provides a useful method and idea for further evaluating the anti-bacterial effect of other drugs and compounds.
    In vivo:
    Proceedings of the National Academy of Sciences, 2014, 48(3):461-471.
    Palmatine hydrochloride improves motor dysfunction in streptozotocin-induced diabetic rats.[Reference: WebLink]
    Diabetes induces motor dysfunctions, Palmatine is an isoquinoline alkaloid, with anti-diabetic and antioxidant activities. This study was conducted to evaluate the effect of Palmatine on motor dysfunction in STZ-induced diabetic rats.
    METHODS AND RESULTS:
    In this experimental study, 32 male wistar rats were randomly allocated into control, Palmatine-treated non-diabetic, diabetic and Palmatine-treated diabetic groups. Diabetes was induced by STZ administration at the dose of 55 mg/kg/bw, intraperitoneally. Palmatine hydrochloride was administered subcutaneous at doses of 10 mg/kg/bw per day for a period of 6 weeks, one week after induction of diabetes. Blood glucose level was measured 1, 3, 5, 7 weeks after STZ injection. Locomotor activity tests including Y maze, grip-traction and inclined plane tests were performed to determining locomotor activity. Results: In Y maze test, the number of arms entered significantly increased in Palmatine-treated diabetic group compared to diabetic group (P<0.05). Grip traction and inclined plane tests significantly increased in Palmatine-treated diabetic group compared to diabetics animals (P<0.05).
    CONCLUSIONS:
    Palmatine hydrochloride administration for 6 weeks improves motor dysfunctions in streptozotocin-induced diabetic rats.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5782 mL 12.8912 mL 25.7825 mL 51.565 mL 64.4562 mL
    5 mM 0.5156 mL 2.5782 mL 5.1565 mL 10.313 mL 12.8912 mL
    10 mM 0.2578 mL 1.2891 mL 2.5782 mL 5.1565 mL 6.4456 mL
    50 mM 0.0516 mL 0.2578 mL 0.5156 mL 1.0313 mL 1.2891 mL
    100 mM 0.0258 mL 0.1289 mL 0.2578 mL 0.5156 mL 0.6446 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    巴马亭红碱; Palmatrubine CFN90505 16176-68-4 C20H20NO4 = 338.38 20mg QQ客服:215959384
    药根碱; Jatrorrhizine CFN98493 3621-38-3 C20H20NO4 = 338.4 20mg QQ客服:2932563308
    格兰地新; Groenlandicine CFN80375 38691-95-1 C19H16NO4 = 322.10 5mg QQ客服:215959384
    盐酸药根碱; Jatrorrhizine Hydrochloride CFN98108 6681-15-8 C20H20ClNO4 = 373.83 20mg QQ客服:2932563308
    非洲防己碱; Columbamine CFN90581 3621-36-1 C20H20NO4 = 338.38 20mg QQ客服:2932563308
    黄藤素; 巴马汀; Palmatine CFN98459 3486-67-7 C21H22NO4 = 352.4 20mg QQ客服:1413575084
    盐酸巴马汀; Palmatine hydrochloride CFN99124 10605-02-4 C21H22ClNO4 = 387.86 20mg QQ客服:1148253675
    1-Methoxyberberine; 1-Methoxyberberine CFN89079 29133-52-6 C21H20NO5 = 352.38 5mg QQ客服:1413575084
    假巴马汀碱; Pseudopalmatine CFN98001 19716-66-6 C21H22NO4 = 352.4 5mg QQ客服:2159513211
    二氢黄藤素; Dihydropalmatine CFN93083 26067-60-7 C21H23NO4 = 353.41 5mg QQ客服:1148253675

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