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    千层纸素A

    Oroxylin A

    千层纸素A
    产品编号 CFN98540
    CAS编号 480-11-5
    分子式 = 分子量 C16H12O5 = 284.26
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The seeds of Oraxylum indicum (L.) Kurz
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    千层纸素A CFN98540 480-11-5 10mg QQ客服:2159513211
    千层纸素A CFN98540 480-11-5 20mg QQ客服:2159513211
    千层纸素A CFN98540 480-11-5 50mg QQ客服:2159513211
    千层纸素A CFN98540 480-11-5 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Aveiro University (Portugal)
  • University of Madras (India)
  • Celltrion Chemical Research Institute (Korea)
  • Worcester Polytechnic Institute (USA)
  • Shanghai Institute of Organic Chemistry (China)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Wroclaw Medical University (Poland)
  • Universidade Federal de Santa Catarina (Brazil)
  • Agricultural Research Organization (ARO) (Israel)
  • University of Hertfordshire (United Kingdom)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Med Rep.2014, 9(5):1653-9
  • Planta Med.2016, 82(13):1208-16
  • J Ethnopharmacol.2017, 196:75-83
  • J Ethnopharmacol.2017, 198:205-213
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • Aquaculture2017, 481:94-102
  • J Hematol Oncol.2018, 11(1):112
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • J Pharm Biomed Anal.2019, 164:119-127
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • New Journal of Chemistry2019, 43:12538-12547
  • Journal of Functional Foods2019, 52:430-441
  • Pharmacol Rep.2019, 71(2):289-298
  • Sci Rep.2019, 9(1):4342
  • Sci Rep.2019, 9(1):6429
  • Saudi Pharm J2020, 10.1016
  • Journal of Chromatography A2020, 460942
  • Nutrients.2020, 12(3):595.
  • Oxid Med Cell Longev.2020, 2020:8887251.
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • Antioxidants (Basel).2020, 9(6):544.
  • Appl. Sci.2021, 11(1),14.
  • ...
  • 生物活性
    Description: Oroxylin A has anticancer,.anti-inflammation, antithrombotic,antibacterial, anti-pruritic effects, it can inhibit LPS-induced iNOS and COX-2 gene expression by blocking NF-κB activation. Oroxylin A reverses MDR by G2/M arrest and the underlying mechanism attributed to the suppression of P-gp expression via Chk2/P53/NF-κB signaling pathway. Oroxylin A facilitates memory consolidation through brain-derived neurotrophic factor (BDNF)-TrkB signaling.
    Targets: TNF-α | ERK | MMP(e.g.TIMP) | NF-kB | Chk | p53 | P-gp | Akt | NOS | COX | PGE | Bcl-2/Bax | NO
    In vitro:
    Arch Pharm Res. 2014 May;37(5):679-86.
    Antithrombotic activities of oroxylin A in vitro and in vivo.[Pubmed: 23963976]

    METHODS AND RESULTS:
    Here, the anticoagulant activities of oroxylin A (OroA), a major component of Scutellaria baicalensis Georgi, were examined by monitoring activated partial thromboplastin time (aPTT), prothrombin time (PT), and the activities of cell-based thrombin and activated factor X (FXa). Furthermore, the effects of OroA on the expressions of plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) were tested in tumor necrosis factor (TNF)-α activated human umbilical vein endothelial cells (HUVECs). Treatment with OroA resulted in prolonged aPTT and PT and inhibition of the activities of thrombin and FXa, and OroA inhibited production of thrombin and FXa in HUVECs. And OroA inhibited thrombin-catalyzed fibrin polymerization and platelet aggregation. In accordance with these anticoagulant activities, OroA elicited anticoagulant effects in mouse. In addition, treatment of OroA resulted in the inhibition of TNF-α-induced production of PAI-1, and treatment with OroA resulted in the significant reduction of the PAI-1 to t-PA ratio.
    CONCLUSIONS:
    Collectively, OroA possess antithrombotic activities and offer bases for development of a novel anticoagulant.
    Eur. J. Pharmacol., 2009, 603(1-3):22-8.
    Oroxylin A suppresses invasion through down-regulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells.[Pubmed: 19100732]
    Our previous study revealed that oroxylin A, a naturally occurring monoflavonoid isolated from Scutellariae radix, could inhibit the proliferation of human hepatocellular carcinoma HepG2 cells through inducing the apoptosis in these cells. However, the molecular mechanism of its anticancer activity remains poorly understood and warrants further investigations.
    CONCLUSIONS:
    In this study, we examined the anti-invasive activities of oroxylin A in vitro. The results showed that oroxylin A suppressed MDA-MB-435 cell adhesion to the fibronectin-coated substrate in a concentration-dependent manner. It inhibited the wound healing migration of MDA-MB-435 cells and invasion of MDA-MB-435 cells through reconstituted extracellular matrix (matrigel). Zymography revealed that oroxylin A decreased the secretion of matrix metalloproteinases-2 (MMP-2) and metalloproteinases-9 (MMP-9). Oroxylin A also inhibited the expressions of MMP-2 and MMP-9 in MDA-MB-435 cells. Additionally, oroxylin A exerted an inhibitory effect on the phosphorylation of extracellular regulated proteinkinases1/2 (ERK1/2). Collectively, these data provided a molecular basis for the antiinvasive effects of oroxylin A.
    CONCLUSIONS:
    Taken together, these findings strongly suggest that oroxylin A had potential anti-metastatic effect in vitro and shed light on the investigation of oroxylin A on breast cancer metastasis in vivo.
    In vivo:
    Brain Res Bull. 2014 Sep;108:67-73.
    Oroxylin A enhances memory consolidation through the brain-derived neurotrophic factor in mice.[Pubmed: 25218897]
    Memory consolidation is a process by which acquired information is transformed from a labile into a more stable state that can be retrieved at a later time. In the present study, we investigated the role of oroxylin A on the memory consolidation process in mice.
    METHODS AND RESULTS:
    Oroxylin A improved the memory retention administered at 0 h, 1 h and 3 h after training in a passive avoidance task, suggesting that oroxylin A facilitates memory consolidation. Oroxylin A increased mature brain-derived neurotrophic factor (mBDNF) levels in the hippocampus from 6h to 24h after administration. Moreover, 3h post-training administration of oroxylin A enhanced the mBDNF level at 9h after the acquisition trial compared to the level at 6h after the acquisition trial. However, 6h post-training administration of oroxylin A did not increase the mBDNF level at 9h after the acquisition trial. Blocking mBDNF signaling with recombinant tropomyosin receptor kinase B (TrkB)-Fc or k252a at 9h after the acquisition trial obstructed the effect of oroxylin A on memory consolidation.
    CONCLUSIONS:
    Taken together, our data suggest that oroxylin A facilitates memory consolidation through BDNF-TrkB signaling and confirms that the increase of BDNF in a specific time window plays a crucial role in memory consolidation.
    Acta Pharmacol Sin. 2010 Jun;31(6):718-24.
    Anti-pruritic effect of baicalin and its metabolites, baicalein and oroxylin A, in mice.[Pubmed: 20453872 ]
    To explore whether intestinal microflora plays a role in anti-pruritic activity of baicalin, a main constituent of the rhizome of Scutellaria baicalensis (SB).
    METHODS AND RESULTS:
    Baicalin was anaerobically incubated with human fecal microflora, and its metabolites, baicalein and oroxylin A, were isolated. The inhibitory effect of baicalin and its metabolites was accessed in histamine- or compound 48/80-induced scratching behavior in mice. Baicalin was metabolized to baicalein and oroxylin A, with metabolic activities of 40.2+/-26.2 and 1.2+/-1.1 nmol.h(-1).mg(-1) wet weight of human fecal microflora, respectively. Baicalin (20, 50 mg/kg) showed more potent inhibitory effect on histamine-induced scratching behavior when orally administered than intraperitoneally. In contrast, baicalein and oroxylin A had more potent inhibitory effect when the intraperitoneally administered. The anti-scratching behavior activity of oral baicalin and its metabolites was in proportion to their inhibition on histamine-induced increase of vascular permeability with oroxylin A more potent than baicalein and baicalin. In Magnus test using guinea pig ileum, oroxylin A is more potent than baicalein and baicalin in inhibition of histamine-induced contraction. The anti-scratching behavioral effect of oral baicalin was significantly reduced when oral antibiotics were simultaneously administered, whereas the effect of baicalein and oroxylin A were not affected.
    CONCLUSIONS:
    Oral baicalin may be metabolized by intestinal microflora into baicalein and oroxylin A, which ameliorate pruritic reactions through anti-histamine action.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5179 mL 17.5895 mL 35.1791 mL 70.3581 mL 87.9477 mL
    5 mM 0.7036 mL 3.5179 mL 7.0358 mL 14.0716 mL 17.5895 mL
    10 mM 0.3518 mL 1.759 mL 3.5179 mL 7.0358 mL 8.7948 mL
    50 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.4072 mL 1.759 mL
    100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.7036 mL 0.8795 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6,7-二羟基黄酮; 6,7-Dihydroxyflavone CFN70351 38183-04-9 C15H10O4 = 254.2 5mg QQ客服:1457312923
    7,8-二羟基黄酮; 7,8-Dihydroxyflavone CFN96512 38183-03-8 C15H10O4 = 254.24 20mg QQ客服:3257982914
    白杨素; Chrysin CFN98741 480-40-0 C15H10O4 = 254.2 20mg QQ客服:2159513211
    5-羟基-7-乙酰氧基黄酮; 5-Hydroxy-7-acetoxyflavone CFN97139 6674-40-4 C17H12O5 = 296.3 5mg QQ客服:2159513211
    5-乙酰氧基-7-羟基黄酮; 5-Acetoxy-7-hydroxyflavone CFN99409 132351-58-7 C17H12O5 = 296.3 5mg QQ客服:1457312923
    5,7-二乙酰氧基黄酮; 5,7-Diacetoxyflavone CFN97138 6665-78-7 C19H14O6 = 338.3 5mg QQ客服:1413575084
    柚木柯因; Tectochrysin CFN98840 520-28-5 C16H12O4 = 268.3 20mg QQ客服:2159513211
    柯因二甲醚; Chrysin dimethylether CFN90896 21392-57-4 C17H14O4 = 282.3 20mg QQ客服:1457312923
    去甲汉黄芩素; Norwogonin CFN92218 4443-09-8 C15H10O5 = 270.2 10mg QQ客服:2159513211
    汉黄芩素; Wogonin CFN97089 632-85-9 C16H12O5 = 284.3 20mg QQ客服:2932563308

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