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  • 木蝴蝶苷B

    Oroxin B

    木蝴蝶苷B
    产品编号 CFN99713
    CAS编号 114482-86-9
    分子式 = 分子量 C27H30O15 = 594.52
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Scutellaria baicalensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    木蝴蝶苷B CFN99713 114482-86-9 10mg QQ客服:2159513211
    木蝴蝶苷B CFN99713 114482-86-9 20mg QQ客服:2159513211
    木蝴蝶苷B CFN99713 114482-86-9 50mg QQ客服:2159513211
    木蝴蝶苷B CFN99713 114482-86-9 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Heidelberg University (Germany)
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  • Celltrion Chemical Research Institute (Korea)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmaceuticals.2022, 15(4), 402.
  • Applied Biological Chemistry2022, 65(85).
  • Turkish Journal of Pharmaceutical Sciences2022, DOI: 10.4274
  • Molecules.2021, 26(8):2161.
  • The Korea Journal of Herbology2020, 35(3):33-45.
  • Biomed Pharmacother.2020, 125:109784.
  • Int J Mol Sci.2023, 24(5):4505.
  • Journal of functional foods2018, 171-182
  • J Cell Mol Med.2023, 27(11):1592-1602.
  • Food Chem.2021, 360:130063.
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Food Science and Biotechnology2023, 2023:1007
  • J Ethnopharmacol.2020, 269:113752.
  • Nat Prod Sci.2018, 24(2):109-114
  • Turk J Med Sci.2023 53: 1312-1320.
  • Crystals2020, 10(3), 206.
  • Foods.2021, 10(12):2929.
  • Phytomedicine.2019, 56:48-56
  • J Chromatogr Sci.2015, 53(5):824-9
  • Plants (Basel).2020, 9(11):1422.
  • Phytochem Anal.2016, 27(5):296-303
  • Biomed Chromatogr.2020, e5021.
  • J Sep Sci.2020, 43(22):4148-4161.
  • ...
  • 生物活性
    Description: Oroxin B can selectively induce tumor-suppressive ER stress and concurrently inhibit tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy.
    Targets: p38MAPK
    In vitro:
    PLoS One. 2013 Nov 27;8(11):e80197.
    Molecular modeling reveals the novel inhibition mechanism and binding mode of three natural compounds to staphylococcal α-hemolysin.[Pubmed: 24312202 ]

    METHODS AND RESULTS:
    In this study, we found that three natural compounds, Oroxylin A 7-O-glucuronide (OLG), Oroxin A (ORA), and Oroxin B (ORB), when inhibiting the hemolytic activity of α-HL, could bind to the "stem" region of α-HL. This was completed using conventional Molecular Dynamics (MD) simulations. By interacting with the novel binding sites of α-HL, the ligands could form strong interactions with both sides of the binding cavity.
    CONCLUSIONS:
    The results of the principal component analysis (PCA) indicated that because of the inhibitors that bind to the "stem" region of α-HL, the conformational transition of α-HL from the monomer to the oligomer was restricted. This caused the inhibition of the hemolytic activity of α-HL.
    In vivo:
    Toxicol Appl Pharmacol. 2015 Oct 15;288(2):269-79.
    Oroxin B selectively induces tumor-suppressive ER stress and concurrently inhibits tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy.[Pubmed: 26253462 ]
    Cancer cells have both tumor-adaptive and -suppressive endoplasmic reticulum (ER) stress machineries that determine cell fate. In malignant tumors including lymphoma, constant activation of tumor-adaptive ER stress and concurrent reduction of tumor-suppressive ER stress favors cancer cell proliferation and tumor growth. Current ER stress-based anti-tumor drugs typically activate both tumor-adaptive and -suppressive ER stresses, resulting in low anti-cancer efficacy; hence, selective induction of tumor-suppressive ER stress and inhibition of tumor-adaptive ER stress are new strategies for novel anti-cancer drug discovery. Thus far, specific tumor-suppressive ER stress therapeutics have remained absent in clinical settings.
    METHODS AND RESULTS:
    In this study, we explored unique tumor-suppressive ER stress agents from the traditional Chinese medicinal herb Oroxylum indicum, and found that a small molecule oroxin B selectively induced tumor-suppressive ER stress in malignant lymphoma cells, but not in normal cells, effectively inhibited lymphoma growth in vivo, and significantly prolonged overall survival of lymphoma-xenografted mice without obvious toxicity. Mechanistic studies have revealed that the expression of key tumor-adaptive ER-stress gene GRP78 was notably suppressed by oroxin B via down-regulation of up-stream key signaling protein ATF6, while tumor-suppressive ER stress master gene DDIT3 was strikingly activated through activating the MKK3-p38 signaling pathway, correcting the imbalance between tumor-suppressive DDIT3 and tumor-adaptive GRP78 in lymphoma.
    CONCLUSIONS:
    Together, selective induction of unique tumor-suppressive ER stress and concurrent inhibition of tumor-adaptive ER stress in malignant lymphoma are new and feasible approaches for novel anti-lymphoma drug discovery and anti-lymphoma therapy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.682 mL 8.4101 mL 16.8203 mL 33.6406 mL 42.0507 mL
    5 mM 0.3364 mL 1.682 mL 3.3641 mL 6.7281 mL 8.4101 mL
    10 mM 0.1682 mL 0.841 mL 1.682 mL 3.3641 mL 4.2051 mL
    50 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.6728 mL 0.841 mL
    100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.3364 mL 0.4205 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    白杨素-7-O-龙胆二糖苷; Chrysin 7-O-beta-gentiobioside CFN90833 88640-89-5 C27H30O14 = 578.5 5mg QQ客服:2056216494
    木蝴蝶苷A; Oroxin A CFN99712 57396-78-8 C21H20O10 = 432.38 20mg QQ客服:2159513211
    黄芩苷; Baicalin CFN99111 21967-41-9 C21H18O11 = 446.37 20mg QQ客服:215959384
    黄芩苷甲酯; Baicalin methyl ester CFN92283 82475-03-4 C22H20O11 = 460.4 20mg QQ客服:2056216494
    黄芩素 7-O-beta-D-葡萄糖醛酸乙酯; Baicalein 7-O-beta-D-ethylglucuronide CFN91993 675624-38-1 C23H22O11 = 474.41 5mg QQ客服:2056216494
    黄芩素 6-O-葡萄糖苷; Baicalein 6-O-glucoside CFN92361 28279-72-3 C21H20O10 = 432.4 5mg QQ客服:2056216494
    木蝴蝶苷B; Oroxin B CFN99713 114482-86-9 C27H30O15 = 594.52 20mg QQ客服:2056216494
    千层纸素A-7-0-β-D-葡萄糖醛酸苷; Oroxylin A 7-O-beta-D-glucuronide CFN90191 36948-76-2 C22H20O11 = 460.39 20mg QQ客服:1413575084
    千层纸素A-7-0-β-D-葡萄糖醛酸苷甲酯; Oroxylin A 7-O-beta-D-glucuronide methyl ester CFN92282 82475-01-2 C23H22O11 = 474.4 5mg QQ客服:1413575084
    Glychionide A; Glychionide A CFN92280 119152-50-0 C21H18O11 = 446.4 5mg QQ客服:215959384

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