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  • 3,5-二羟基甲苯

    Orcinol

    3,5-二羟基甲苯
    产品编号 CFN98796
    CAS编号 504-15-4
    分子式 = 分子量 C7H8O2 = 124.1
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Phenols
    植物来源 The roots of Curculigo orchioides Gaertn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3,5-二羟基甲苯 CFN98796 504-15-4 10mg QQ客服:2056216494
    3,5-二羟基甲苯 CFN98796 504-15-4 20mg QQ客服:2056216494
    3,5-二羟基甲苯 CFN98796 504-15-4 50mg QQ客服:2056216494
    3,5-二羟基甲苯 CFN98796 504-15-4 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • University Medical Center Mainz (Germany)
  • University of Amsterdam (Netherlands)
  • University of Lodz (Poland)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • University of Limpopo2016, 1777
  • Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2020, 37(9):1437-1448.
  • Molecules.2019, 24(21):E3834
  • J Food Sci.2021, 86(9):3810-3823.
  • Appl. Sci.2020, 10(16),5482.
  • Metabolites.2023, 13(5):625.
  • Oncol Lett.2020, 20(4):122.
  • Braz J Biol.2023, 82:e266573.
  • Plants2022, 11(3),294.
  • Horticulture Research2022, uhac276.
  • Hum Exp Toxicol.2022, 41:9603271221143713.
  • J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
  • Korean J. Medicinal Crop Sci.2022, 30(2):117-123.
  • Chem Biol Interact.2016, 260:168-175
  • Nutrients.2021, 13(10):3414.
  • Pamukkale Medical Journal2022, 15(4):796-803.
  • Applied Biological Chemistry2022, 65(77).
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • Cell Chem Biol.2019, 26(1):27-34
  • J Appl Biol Chem2021, 64(3):245-251.
  • Food Sci Nutr.2023, 00:1-10.
  • Molecules.2018, 23(7):E1659
  • PLoS One.2021, 16(9):e0257243.
  • ...
  • 生物活性
    Description: Orcinol glucoside is anxiolytic agent without sedative effect, it improves depressive behaviour in CUMS rats by downregulating HPA axis hyperactivity and increasing BDNF expression and ERK1/2 phosphorylation in the hippocampus.
    Targets: ERK | BDNF
    In vivo:
    Eur Neuropsychopharmacol. 2014 Jan;24(1):172-80.
    Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress.[Pubmed: 23838013]
    This study focused on the antidepressant potential of Orcinol glucoside (OG) and its possible mechanisms of action.
    METHODS AND RESULTS:
    We established a depressed rat model using 3 consecutive weeks of chronic unpredictable mild stress (CUMS). The antidepressant-like effect of Orcinol glucoside was revealed using the sucrose preference test, the open field test, the forced swimming test (FST), and the tail suspension test (TST). The activity of the hypothalamic-pituitary-adrenal (HPA) axis was evaluated by detecting the serum corticosterone (CORT) concentrations and mRNA expression of corticotrophin-releasing hormone (CRH) in the hypothalamus. The protein expression levels of brain-derived neurotrophic factor (BDNF) and total phosphorylated-ERK1/2 were detected by western blot. The results showed that Orcinol glucoside treatment (1.5, 3, or 6mg/kg) alleviated the depression-like behaviour of rats under CUMS, as indicated by the increased sucrose preference and the decreased immobility in both the FST and TST, although the rearing frequency in the open field test increased only in the group that received the lowest dose (1.5mg/kg OG). Rats that received Orcinol glucoside treatment exhibited reduced serum CORT levels and CRH mRNA expression in the hypothalamus, suggesting that the hyperactivity of the HPA axis in CUMS rats was reversed by Orcinol glucoside treatment. Moreover, Orcinol glucoside treatment upregulated the protein levels of BDNF and phosphorylated-ERK1/2 in the hippocampus, even above control levels.
    CONCLUSIONS:
    Our findings suggest that Orcinol glucoside improved depressive behaviour in CUMS rats by downregulating HPA axis hyperactivity and increasing BDNF expression and ERK1/2 phosphorylation in the hippocampus.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 8.058 mL 40.2901 mL 80.5802 mL 161.1604 mL 201.4504 mL
    5 mM 1.6116 mL 8.058 mL 16.116 mL 32.2321 mL 40.2901 mL
    10 mM 0.8058 mL 4.029 mL 8.058 mL 16.116 mL 20.145 mL
    50 mM 0.1612 mL 0.8058 mL 1.6116 mL 3.2232 mL 4.029 mL
    100 mM 0.0806 mL 0.4029 mL 0.8058 mL 1.6116 mL 2.0145 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2,4-二羟基苯乙酮; 2,4-Dihydroxyacetophenone CFN97463 89-84-9 C8H8O3 = 152.2 20mg QQ客服:2159513211
    丹皮酚; Paeonol CFN98926 552-41-0 C9H10O3 = 166.2 20mg QQ客服:2056216494
    4-甲氧基水杨酸乙酯; Ethyl 4-methoxysalicylate CFN92590 60770-00-5 C10H12O4 = 196.2 5mg QQ客服:3257982914
    2,5-二羟基苯乙酮; 2,5-Dihydroxyacetophenone CFN93182 490-78-8 C8H8O3 = 152.2 20mg QQ客服:215959384
    香草乙酮; Acetovanillone CFN90802 498-02-2 C9H10O3 = 166.2 20mg QQ客服:1457312923
    Phloracetophenone 4'-O-glucoside; Phloracetophenone 4'-O-glucoside CFN96153 5027-30-5 C14H18O9 = 330.3 10mg QQ客服:3257982914
    新化合物26; New compound 26 CFN95622 N/A C30H36O16 = 652.6 5mg QQ客服:1413575084
    2',4',6'-三羟基苯乙酮; 2',4',6'-Trihydroxyacetophenone CFN96090 480-66-0 C8H8O4 = 168.2 20mg QQ客服:3257982914
    2,4-二羟基苯乙酸; 2,4-Dihydroxyphenylacetic acid CFN97051 614-82-4 C8H8O4 = 168.2 5mg QQ客服:1413575084
    榼藤子苷; Phaseoloidin CFN91665 118555-82-1 C14H18O9 = 330.29 5mg QQ客服:1413575084

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