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    Ophiopogonin B

    产品编号 CFN98555
    CAS编号 38971-41-4
    分子式 = 分子量 C39H62O12 = 722.91
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The tubers of Ophiopogon japonicus Ker-Gawler cv. Nanus
    产品名称 产品编号 CAS编号 包装 QQ客服
    麦冬皂苷B CFN98555 38971-41-4 1mg QQ客服:2159513211
    麦冬皂苷B CFN98555 38971-41-4 5mg QQ客服:2159513211
    麦冬皂苷B CFN98555 38971-41-4 10mg QQ客服:2159513211
    麦冬皂苷B CFN98555 38971-41-4 20mg QQ客服:2159513211
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  • 生物活性
    Description: Ophiopogonin B is often used in Chinese traditional medicine to treat pulmonary disease, it is a prospective inhibitor of PI3K/Akt and may be used as an alternative compound to treat NSCLC. It may be considered a potential inhibitor of gastric cancer progression, and may be used as an alternative compound for its treatment. Ophiopogonin B induces apoptosis, mitotic catastrophe and autophagy , has inhibitory effect on adhesion, invasion and migration of A549 cells in vitro.
    Targets: Caspase | PI3K | Akt | mTOR | ROS | ERK | JNK | Bcl-2/Bax | MMP(e.g.TIMP)
    In vitro:
    Oncol Rep. 2013 Feb;29(2):430-6.
    Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway.[Pubmed: 23151908]
    Ophiopogonin B (OP-B) is a bioactive component of Radix Ophiopogon Japonicus, which is often used in Chinese traditional medicine to treat pulmonary disease. However, whether or not Ophiopogonin B has any potential antitumor activity has not been reported.
    Here, we show that the non-small cell lung cancer (NSCLC) cell lines NCI-H157 and NCI-H460 treated with Ophiopogonin B grow more slowly and accumulate vacuoles in their cytoplasm compared to untreated control cells. Flow cytometric analysis showed that the cells were arrested in G0/G1 phase. Nuclear morphology, Annexin-V/PI staining, and expression of cleaved caspase-3 all confirm that Ophiopogonin B does not induce apoptosis. Instead, based on results from both transmission electron microscopy (TEM) and the expression of microtubule-associated protein 1 light chain 3-II (LC3-II), we determined that Ophiopogonin B treatment induced autophagy in both cell lines. Next, we examined the PI3K/Akt/mTOR signaling pathway and found that Ophiopogonin B inhibited phosphorylation of Akt (Ser473, Thr308) in NCI-H157 cells and also inhibited several key components of the pathway in NCI-H460 cells, such as p-Akt(Ser473, Thr308), p-p70S6K (Thr389). Additionally, insulin-mediated activation of the PI3K/Akt/mTOR pathway provides evidence that activation of this pathway may correlate with induction of autophagy in H460 cells.
    Therefore, Ophiopogonin B is a prospective inhibitor of PI3K/Akt and may be used as an alternative compound to treat NSCLC.
    Mol Med Rep. 2016 Jun;13(6):4981-6.
    Effects of ophiopogonin B on the proliferation and apoptosis of SGC‑7901 human gastric cancer cells.[Pubmed: 27121658 ]
    Ophiopogonin B (OP‑B) is a bioactive component of Radix Ophiopogon japonicus, which is often used in traditional Chinese medicine to treat cancer.
    The present study aimed to investigate the antitumor activity of OP‑B in gastric cancer. Cell Counting kit‑8, flow cytometry with Annexin V‑fluorescein isothiocyanate, Hoechst staining, mitochondrial membrane potential (MMP) detection, and reactive oxygen species (ROS) assay were used to detect the biological function of SGC‑7901 gastric cancer cells. The results demonstrated that high concentrations of OP‑B (5, 10 and 20 μmol/l) exerted potent antiproliferative effects on SGC‑7901 cells in a dose‑dependent manner. Furthermore, apoptotic rates were increased and cell morphology was altered following treatment with OP‑B. In addition, OP‑B‑induced apoptosis of SGC‑7901 cells was associated with loss of MMP and increased ROS generation. Western blotting indicated that treatment with OP‑B increased the protein expression levels of caspase‑3 and B‑cell lymphoma 2 (Bcl‑2)‑associated X protein, whereas the expression levels of Bcl‑2 and the phosphorylation levels of extracellular signal‑regulated kinases 1/2 and c‑Jun N‑terminal kinases 1/2 were decreased.
    These results suggest that OP‑B may be considered a potential inhibitor of gastric cancer progression, and may be used as an alternative compound for its treatment.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3833 mL 6.9165 mL 13.833 mL 27.666 mL 34.5825 mL
    5 mM 0.2767 mL 1.3833 mL 2.7666 mL 5.5332 mL 6.9165 mL
    10 mM 0.1383 mL 0.6916 mL 1.3833 mL 2.7666 mL 3.4582 mL
    50 mM 0.0277 mL 0.1383 mL 0.2767 mL 0.5533 mL 0.6916 mL
    100 mM 0.0138 mL 0.0692 mL 0.1383 mL 0.2767 mL 0.3458 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    鲁斯可皂苷元; Ruscogenin CFN99530 472-11-7 C27H42O4 = 430.63 20mg QQ客服:1457312923
    新鲁斯可皂苷元; Neoruscogenin CFN80032 17676-33-4 C27H40O4 = 428.61 5mg QQ客服:3257982914
    25(S)-鲁斯可皂苷元-1-O-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃木糖苷; (1beta,3beta,25S)-3-Hydroxyspirost-5-en-1-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-xylopyranoside CFN80078 125225-63-0 C38H60O12 = 708.88 5mg QQ客服:2159513211
    麦冬皂苷B; Ophiopogonin B CFN98555 38971-41-4 C39H62O12 = 722.91 10mg QQ客服:2932563308
    山麦冬皂苷B; Liriopesides B CFN90675 87425-34-1 C39H62O12 = 722.9 20mg QQ客服:2159513211
    麦冬皂苷A; Ophiopogonin A CFN98554 11054-24-3 C41H64O13 = 764.94 10mg QQ客服:2159513211
    山麦冬皂苷B; Lirioprolioside B CFN90599 182284-68-0 C41H64O13 = 764.95 20mg QQ客服:1413575084
    麦冬皂苷D; Ophiopogonin D CFN98156 41753-55-3 C44H70O16 = 855.02 20mg QQ客服:2159513211
    短葶山麦冬皂苷C; Liriope muscari baily Saponins C CFN90681 130551-41-6 C44H70O17 = 871.0 20mg QQ客服:2056216494
    麦冬皂苷C; Ophiopogonin C CFN98556 911819-08-4 C46H72O17 = 897.06 10mg QQ客服:3257982914





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