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  • 芒柄花苷

    Ononin

    芒柄花苷
    产品编号 CFN99136
    CAS编号 486-62-4
    分子式 = 分子量 C22H22O9 = 430.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Ononis natrix L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    芒柄花苷 CFN99136 486-62-4 10mg QQ客服:2932563308
    芒柄花苷 CFN99136 486-62-4 20mg QQ客服:2932563308
    芒柄花苷 CFN99136 486-62-4 50mg QQ客服:2932563308
    芒柄花苷 CFN99136 486-62-4 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Auckland (New Zealand)
  • Universiti Sains Malaysia (Malaysia)
  • University of Illinois (USA)
  • Tohoku University (Japan)
  • Colorado State University (USA)
  • Sapienza University of Rome (Italy)
  • Worcester Polytechnic Institute (USA)
  • Instituto Politécnico de Bragan?a (Portugal)
  • University of Minnesota (USA)
  • Chiang Mai University (Thailand)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Agricultural Research Organization (ARO) (Israel)
  • University of Sao Paulo (Brazil)
  • The Institute of Cancer Research (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean Journal of Pharmacognosy2014, 113-120
  • Int J Mol Sci.2015, 16(1):1232-51
  • Evid Based Complement Alternat Med.2015, 2015:165457
  • Acta Physiologiae Plantarum2015, 37:1736
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • SBRAS2016, 12
  • Acta Physiologiae Plantarum2016, 38:7
  • BMC Complement Altern Med.2017, 17(1):393
  • J Biochem Mol Toxicol.2017, 31(9)
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • Journal of Analytical Chemistry2017, 854-861
  • Lab Chip.2018, 18(6):971-978
  • Sci Rep.2018, 8(1):12970
  • J Mol Med (Berl).2018, 96(7):661-672
  • Phytother Res.2019, 10.1002
  • Molecules.2019, 24(16):E2985
  • Med Sci Monit.2019, 25:9499-9508
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Environ Toxicol.2019, 34(12):1354-1362
  • Metabolites.2019, 9(11):E271
  • Plant Foods Hum Nutr.2020, 10.1007
  • Antioxidants (Basel).2020, 9(2):E99
  • ...
  • 生物活性
    Description: Ononin is an additional growth inhibitor in soils associated with the weed, Pluchea lanceolata, it can significantly inhibit root and shoot growth of mustard at 1×10(-4) M, 5×10(-4) M, and 1×10(-3)M , and inhibit the growth of pathogen such as Enterococcus sp., Enterobacter sp. and can promote the growth of probiotics such as Bifidobacteria sp. and Lactobacilli sp. Ononin has weak DPPH·free radical and the superoxide anion free radical scavenging capacity.
    Targets: HIF | Antifection
    In vitro:
    Yao Xue Xue Bao. 2014 Aug;49(8):1162-8.
    The interaction between ononin and human intestinal bacteria[Pubmed: 25322559]

    METHODS AND RESULTS:
    The study aims to screen the ability of the bacteria to metabolize ononin and assess the effect of ononin on the intestinal bacteria. Fresh human fecal sample was obtained from a healthy volunteer, diluted serially in sterile water and sixty-nine different bacterial colonies were picked out ultimately. UPLC-Q-TOF/MS with automated data analysis software (MetaboLynx) was applied to fast analysis of ononin metabolites. Furthermore, an E(max) precision microplate reader was employed to determine the growth situation of Enterococcous sp., Enterobacter sp., Lactobacilli sp., and Bifidobacteria sp. Results indicated that hydrogenation, demethylation, hydroxylation and deglycosylation were the major metabolic pathways of ononin by human intestinal bacteria in vitro. Ononin can inhibit the growth of pathogen such as Enterococcus sp., Enterobacter sp. and can promote the growth of probiotics such as Bifidobacteria sp. and Lactobacilli sp.
    CONCLUSIONS:
    This study suggested that intestinal bacteria have the metabolic effects of ononin and the biotransformation was completed by different bacteria. And ononin can affect the balance of intestinal flora and the degree of influence varies depending on the bacterial species and the concentration of ononin.
    J Chem Ecol. 1992 May;18(5):713-8.
    Formononetin 7-O-glucoside (ononin), an additional growth inhibitor in soils associated with the weed,Pluchea lanceolata (DC) C.B. Clarke (Asteraceae).[Pubmed: 24253965 ]
    Formononetin 7-O-glucoside (ononin), an isoflavonoid, was isolated from the soils of cultivated areas associated with the perennial weed,Pluchea lanceolata. Aqueous solutions of this compound inhibited significantly root and shoot growth of mustard at 1×10(-4) M, 5×10(-4) M, and 1×10(-3)M. The level of inhibition was similar to that of hesperidin and taxifolin 3-arabinoside, as reported earlier. The potential allelopathic effect of this compound under field conditions is discussed.
    J. Anhui Agricul. Universit., 2011, 38(2):151-5.
    Free radical scavenging capacities of isoflavonoid glycosides isolated from Pueraria Radix.[Reference: WebLink]

    METHODS AND RESULTS:
    Crude total isoflavonoids extracted from Pueraria Radix were partitioned by different organic solvents,then isolated and purified by several column chromatographic techniques and four isoflavonoid gly-cosides were obtained.On basis of the NMR and ESI-MS spectra,these four compounds can be identified as pu-erarin,daidzin,ononin,and genistin,respectively.Using an organic free radical system of 1,1-diphenyl-2-picrylhydrazyl(DPPH·) and an inorganic free radical system of superoxide anion free radical,the free radical scavenging capacities and antioxidant activities of these four isoflavonoid glycosides were examined in vitro.The results showed that all the four isoflavonoid glycosides were discovered to possess the scavenging capacities of the DPPH·free radical and superoxide anion radical.Meanwhile,there was a significantly positive correlation between the two free radical scavenging capacities and the treated concentrations of the four isoflavonoid gly-cosides.Genistin showed the highest DPPH·free radical scavenging capacity,followed by daidzin and puerarin,and ononin was the lowest among them.
    CONCLUSIONS:
    However,the superoxide anion free radical scavenging capacities of the four isoflavonoid glycosides were different from the former.Puerarin was discovered to be the strongest among them,followed by daidzin,genistin and ononin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3234 mL 11.6171 mL 23.2342 mL 46.4684 mL 58.0855 mL
    5 mM 0.4647 mL 2.3234 mL 4.6468 mL 9.2937 mL 11.6171 mL
    10 mM 0.2323 mL 1.1617 mL 2.3234 mL 4.6468 mL 5.8086 mL
    50 mM 0.0465 mL 0.2323 mL 0.4647 mL 0.9294 mL 1.1617 mL
    100 mM 0.0232 mL 0.1162 mL 0.2323 mL 0.4647 mL 0.5809 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4'-O-甲氧基葛根素; 4'-Methoxypuerarin CFN90782 92117-94-7 C22H22O9 = 430.4 10mg QQ客服:1413575084
    葛根素-6''-O-木糖苷; Puerarin 6''-O-xyloside CFN90640 114240-18-5 C26H28O13 = 548.49 20mg QQ客服:3257982914
    Formononetin-8-C-beta-D-apiofuranosyl-(1→6)-O-beta-D-glucopyranoside; Formononetin-8-C-beta-D-apiofuranosyl-(1->6)-O-beta-D-glucopyranoside CFN95157 1147858-78-3 C27H30O13 = 562.5 10mg QQ客服:1413575084
    美佛辛-4'-O-葡萄糖苷; Mirificin-4'-O-glucoside CFN95091 168035-01-6 C32H38O18 = 710.6 5mg QQ客服:215959384
    3'-羟基葛根素; 3'-Hydroxy Puerarin CFN90236 117076-54-5 C21H20O10 = 432.38 20mg QQ客服:215959384
    3'-甲氧基葛根素; 3'-Methoxypuerarin CFN90780 117047-07-1 C22H22O10 = 446.4 20mg QQ客服:1413575084
    大豆苷; Daidzin CFN99101 552-66-9 C21H20O9 = 416.38 20mg QQ客服:2159513211
    大豆苷元-7-O-葡萄糖醛酸苷; Daidzein 7-O-glucuronide CFN70352 38482-80-3 C21H18O10 = 430.4 5mg QQ客服:2932563308
    二氢大豆苷; Dihydrodaidzin CFN90755 121927-96-6 C21H22O9 = 418.4 5mg QQ客服:1148253675
    4''-甲氧基大豆苷; 4''-methyloxy-Daidzin CFN93005 1195968-02-5 C22H22O9 = 430.40 5mg QQ客服:2159513211

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