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    远志皂苷B

    Onjisaponin B

    远志皂苷B
    产品编号 CFN90600
    CAS编号 35906-36-6
    分子式 = 分子量 C75H112O35 = 1573.69
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Polygala tenuifolia.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    远志皂苷B CFN90600 35906-36-6 1mg QQ客服:1413575084
    远志皂苷B CFN90600 35906-36-6 5mg QQ客服:1413575084
    远志皂苷B CFN90600 35906-36-6 10mg QQ客服:1413575084
    远志皂苷B CFN90600 35906-36-6 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Shanghai Institute of Organic Chemistry (China)
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  • Mahatma Gandhi University (India)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Oncol Rep.2016, 35(3):1356-64
  • Planta Med.2016, 82(13):1208-16
  • J Ethnopharmacol.2017, 196:75-83
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  • Pharmacol Rep.2019, 71(2):289-298
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  • Sci Rep.2019, 9(1):4646
  • Plos One.2020, 10.1371
  • Nutrients2020, 12(2):488
  • JABS2020, 14:2(2020)
  • Int J Mol Sci.2020, 21(24):9369.
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • J Food Biochem.2020, 44(6):e13198.
  • Biochem Biophys Res Commun.2020, 530(1):4-9.
  • Pharmacol Rep.2020, 72(2):472-480.
  • ...
  • 生物活性
    Description: Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α-synuclein, it may have potential therapeutic effects on Parkinson disease, Alzheimer disease and Huntington disease. Onjisaponins may provide safe and potent adjuvants for intranasal inoculation of influenza HA and DPT vaccines.
    Targets: AMPK | mTOR | PGE | TNF-α | NGF
    In vitro:
    Int J Mol Sci. 2013 Nov 15;14(11):22618-41.
    Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells.[Pubmed: 24248062]
    Emerging evidence indicates important protective roles being played by autophagy in neurodegenerative disorders through clearance of aggregate-prone or mutant proteins.
    METHODS AND RESULTS:
    In the current study, we aimed to identify autophagy inducers from Chinese medicinal herbs as a potential neuroprotective agent that enhances the clearance of mutant huntingtin and α-synuclein in PC-12 cells. Through intensive screening using the green fluorescent protein-light chain 3 (GFP-LC3) autophagy detection platform, we found that the ethanol extracts of Radix Polygalae (Yuan Zhi) were capable of inducing autophagy. Further investigation showed that among three single components derived from Radix Polygalae--i.e., polygalacic acid, senegenin and onjisaponin B--onjisaponin B was able to induce autophagy and accelerate both the removal of mutant huntingtin and A53T α-synuclein, which are highly associated with Huntington disease and Parkinson disease, respectively. Our study further demonstrated that onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway.
    CONCLUSIONS:
    Therefore, findings in the current study provide detailed insights into the protective mechanism of a novel autophagy inducer, which is valuable for further investigation as a new candidate agent for modulating neurodegenerative disorders through the reduction of toxicity and clearance of mutant proteins in the cellular level.
    Biomed Res Int. 2015;2015:918048.
    The gastrointestinal irritation of polygala saponins and its potential mechanism in vitro and in vivo.[Pubmed: 25705699]
    Processing alters the pharmacological activity and reduces the gastrointestinal toxicity of the polygalae.
    METHODS AND RESULTS:
    To investigate the effect of processing, different glycosyl substituent products were tested. Hypnotic and subhypnotic doses of pentobarbital-induced sleep tests on mice were used to evaluate the sedative activity of polygala saponins with different glycosyl substituents; isolated gut motility experiment was employed to study excitatory effects of different polygala saponins; the gastrointestinal irritation effects of different polygala saponins were compared by measuring the levels of gastric PGE2 and intestinal TNF-α on mice. When compared with control, Onjisaponin B (OJB) and tenuifolin (TEN), but not senegenin (SNG), significantly increased the number of sleeping mice and prolonged the sleeping time (P < 0.05); 80, 40, and 20 mg/L of OJB and 80 mg/L of TEN, but not SNG, obviously changed the amplitude and frequency of isolated jejunum (P < 0.05); all the three compounds significantly decreased the level of gastric PGE2 but had no obvious influences on the reduction of intestinal TNF-α level. For sedative and hypnotic effects, OJB > TEN > SNG; for the protection form gastrointestinal irritation and damages, OJB > TEN > SNG.
    CONCLUSIONS:
    Therefore, in processing Polygala, glycosyl breaking may be related to the decline of pharmacological activity and gastrointestinal toxicity of polygala saponins.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.6354 mL 3.1772 mL 6.3545 mL 12.709 mL 15.8862 mL
    5 mM 0.1271 mL 0.6354 mL 1.2709 mL 2.5418 mL 3.1772 mL
    10 mM 0.0635 mL 0.3177 mL 0.6354 mL 1.2709 mL 1.5886 mL
    50 mM 0.0127 mL 0.0635 mL 0.1271 mL 0.2542 mL 0.3177 mL
    100 mM 0.0064 mL 0.0318 mL 0.0635 mL 0.1271 mL 0.1589 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    常春藤苷D; 常春藤皂苷D; Hederacoside D CFN90184 760961-03-3 C53H86O22 = 1074.56 20mg QQ客服:1413575084
    瓜子金皂苷戊; Polygalasaponin E CFN95138 882664-72-4 C47H74O19 = 943.1 5mg QQ客服:1457312923
    瓜子金皂苷己; Polygalasaponin F CFN90171 882664-74-6 C53H86O23 = 1091.3 20mg QQ客服:1457312923
    瓜子金皂苷V; Polygalasaponin V CFN90650 162857-65-0 C58H94O27 = 1222.59 20mg QQ客服:3257982914
    远志皂苷D; Polygalacin D CFN93351 66663-91-0 C57H92O27 = 1209.4 10mg QQ客服:1413575084
    红毛七皂苷F; Cauloside F CFN93269 60451-47-0 C59H96O27 = 1237.4 5mg QQ客服:3257982914
    常春藤苷C; 常春藤皂苷C; Hederacoside C CFN90183 14216-03-6 C59H96O26 = 1221.38 20mg QQ客服:1413575084
    川续断皂苷乙; Dipsacoside B CFN99150 33289-85-9 C53H86O22 = 1074.56 20mg QQ客服:1457312923
    白头翁皂苷H; Pulsatilla saponin H CFN80187 68027-14-5 C65H106O31 = 1382.67 5mg QQ客服:2932563308
    土贝母苷甲; Tubeimoside I CFN99990 102040-03-9 C63H98O29 = 1319.46 20mg QQ客服:3257982914

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