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  • 三七皂苷Fc

    Notoginsenoside Fc

    三七皂苷Fc
    产品编号 CFN93283
    CAS编号 88122-52-5
    分子式 = 分子量 C58H98O26 = 1211.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax notoginseng
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    三七皂苷Fc CFN93283 88122-52-5 10mg QQ客服:215959384
    三七皂苷Fc CFN93283 88122-52-5 20mg QQ客服:215959384
    三七皂苷Fc CFN93283 88122-52-5 50mg QQ客服:215959384
    三七皂苷Fc CFN93283 88122-52-5 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Medical University of South Carolina (USA)
  • University of Cincinnati (USA)
  • Regional Crop Research Institute (Korea)
  • Siksha O Anusandhan University (India)
  • Monash University (Australia)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Semmelweis Unicersity (Hungary)
  • Max-Planck-Insitut (Germany)
  • Celltrion Chemical Research Institute (Korea)
  • University of Minnesota (USA)
  • Kyushu University (Japan)
  • University of Toronto (Canada)
  • Amity University (India)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • University of Limpopo2016, 1777
  • Chemistry of Plant Materials.2016, 33-46
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Oncotarget.2016, 8(51):88386-88400
  • Biochem Systematics and Ecology2017, 11-18
  • Plant Methods.2017, 13:108
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • The Japan Society for Analytical Chemistry2017, 613-617
  • J Agric Food Chem.2017, 65(13):2670-2676
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • J Ethnopharmacol.2018, 210:88-94
  • Front Pharmacol.2019, 10:1355
  • International J of Green Pharmacy2019, 13(3)
  • Food Engineering Progress2019, 23(3)209-216
  • Molecules.2019, 24(7):E1290
  • Food Chem.2019, 275:746-753
  • Phytother Res.2019, 33(4):1104-1113
  • J Asian Nat Prod Res.2019, 5:1-17
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • Int Immunopharmacol.2019, 71:22-31
  • J Nat Prod.2019, 82(4):1002-1008
  • Food and Chemical Toxicology2020, 111221
  • Pharmacological Reports2020, 1-9
  • ...
  • 生物活性
    Description: Notoginsenoside Fc has perfect anti-platelet aggregatory effect.
    Targets: PAFR
    In vivo:
    J Pharm Biomed Anal. 2015 May 10;109:150-7.
    Pharmacokinetics, bioavailability, and metabolism of Notoginsenoside Fc in rats by liquid chromatography/electrospray ionization tandem mass spectrometry.[Pubmed: 25770412]
    Notoginsenoside Fc (NGFc) is a protopanaxadiol-type (PPD-type) saponin from Panax notoginseng, which has perfect anti-platelet aggregatory effect. However, its pharmacokinetics and metabolism in vivo remain unknown.
    METHODS AND RESULTS:
    In this study, a simple and sensitive liquid chromatography/electrospray ionization tandem mass spectrometry (LC-MS/MS) method was first developed for the determination of NGFc in rat plasma. After methanol-mediated protein precipitation, separation was achieved on a C18 column with MS detection operated in negative SRM mode at m/z 604.56→m/z 783.90 and m/z 799.93→m/z 637.64 for NGFc and IS, respectively. The assay was linear over the concentration range (r>0.995) with the LLOQ of 0.002μg/ml. The intra- and inter-day precisions (R.S.D.) were 2.45-12.36% and 3.67-14.22%, respectively; whereas accuracy ranged from (R.R.) 93.90% to 99.41%. The extraction recovery, stability, and matrix effect were within the acceptable limits.
    CONCLUSIONS:
    The validated LC-MS/MS method was successfully applied to the pre-clinical pharmacokinetic studies of NGFc in rat. After oral and intravenous administration, NGFc showed dose-independent pharmacokinetic behaviors with a t1/2 of >22h and its oral bioavailability was 0.10-0.14%. In addition, a total of 10 metabolites were detected and structurally characterized by UPLC-Q/TOF-MS technique, which suggested that deglycosylation was the major metabolic pathway for NGFc in rats.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.8255 mL 4.1275 mL 8.2549 mL 16.5098 mL 20.6373 mL
    5 mM 0.1651 mL 0.8255 mL 1.651 mL 3.302 mL 4.1275 mL
    10 mM 0.0825 mL 0.4127 mL 0.8255 mL 1.651 mL 2.0637 mL
    50 mM 0.0165 mL 0.0825 mL 0.1651 mL 0.3302 mL 0.4127 mL
    100 mM 0.0083 mL 0.0413 mL 0.0825 mL 0.1651 mL 0.2064 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    三七皂苷Fe; Notoginsenoside Fe CFN93282 88105-29-7 C47H80O17 = 917.12 20mg QQ客服:1148253675
    人参皂苷Rc; Ginsenoside Rc CFN99973 11021-14-0 C53H90O22 = 1079.27 20mg QQ客服:2159513211
    人参皂苷F1; Ginsenoside F1 CFN99754 53963-43-2 C36H62O9 = 638.88 20mg QQ客服:2159513211
    3-乙酰人参皂苷F1; 3-Acetyl-ginsenoside F1 CFN95238 N/A C38H64O10 = 680.9 5mg QQ客服:3257982914
    人参皂苷F3; Ginsenoside F3 CFN99978 62025-50-7 C41H70O13 = 770.99 10mg QQ客服:215959384
    人参皂苷F5; Ginsenoside F5 CFN95034 189513-26-6 C41H70O13 = 771.0 20mg QQ客服:215959384
    人参皂苷Rg1; Ginsenoside Rg1 CFN99967 22427-39-0 C42H72O14 = 801.01 20mg QQ客服:1413575084
    三七皂苷R1; Notoginsenoside R1 CFN99999 80418-24-2 C47H80O18 = 933.13 20mg QQ客服:3257982914
    人参皂苷Re; Ginsenoside Re CFN99974 52286-59-6 C48H82O18 = 947.15 20mg QQ客服:2932563308
    人参皂苷Rd; Ginsenoside Rd CFN99975 52705-93-8 C48H82O18 = 947.2 20mg QQ客服:2159513211

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