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  • 3,6,8-三羟基-1-甲基呫吨酮

    Norlichexanthone

    3,6,8-三羟基-1-甲基呫吨酮
    产品编号 CFN98041
    CAS编号 20716-98-7
    分子式 = 分子量 C14H10O5 = 258.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Xanthones
    植物来源 From Cucurbitaria sp.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3,6,8-三羟基-1-甲基呫吨酮 CFN98041 20716-98-7 1mg QQ客服:2159513211
    3,6,8-三羟基-1-甲基呫吨酮 CFN98041 20716-98-7 5mg QQ客服:2159513211
    3,6,8-三羟基-1-甲基呫吨酮 CFN98041 20716-98-7 10mg QQ客服:2159513211
    3,6,8-三羟基-1-甲基呫吨酮 CFN98041 20716-98-7 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universiti Malaysia Pahang (Malaysia)
  • University of Stirling (United Kingdom)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Kazusa DNA Research Institute (Japan)
  • Charles Sturt University (Denmark)
  • Istanbul University (Turkey)
  • Universidade de Franca (Brazil)
  • CSIRO - Agriculture Flagship (Australia)
  • Uniwersytet Gdański (Poland)
  • University of Auckland (New Zealand)
  • Periyar University (India)
  • University of Maryland (USA)
  • Aarhus University (Denmark)
  • Ateneo de Manila University (Philippines)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chem Biol Interact.2018, 283:59-74
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Neuropharmacology.2018, 131:68-82
  • Current Topics in Nutraceutical Research2021, 19(1),p90-105.
  • Appl. Sci.2021, 11(1),14.
  • Plant Pathology2022, 13527
  • Int J Mol Sci.2017, 18(5)
  • Analytical methods2019, 11(6)
  • Nutrients2022, 14(14)2929
  • Food Res Int.2018, 106:909-919
  • Biomed Pharmacother.2023, 163:114785.
  • Phytother Res.2019, 33(4):1104-1113
  • BioResources J.2020, 15(3).
  • J Biochem Mol Toxicol.2020, 34(7):e22489.
  • J Ethnopharmacol.2017, 198:205-213
  • Analytical Letters.2020, doi 10.1008
  • Heliyon.2023, 9(12):e22932.
  • Arch Pharm Res.2015, 38(6):1080-9
  • Appl. Sci.2020, 10(20), 7323.
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • Exp Neurobiol.2018, 27(3):200-209
  • Processes2022, 10(10), 2008.
  • Agriculture.2022, 12(3), 342.
  • ...
  • 生物活性
    Description: Norlichexanthone has the potential to treat and/or prevent lifestyle-related diseases, including metabolic syndrome, type 2 diabetes, atherosclerosis and cardiovascular diseases.Norlichexanthone has antibacterial and antimalarial activities, it shows strong activity against Bacillus subtilis with IC50 in the range of 1-5uM, it also significantly inhibits the growth of methicillin-resistant Staphylococcus aureus with IC50 of 20.95±1.56uM.
    Targets: PPAR | Antifection
    In vitro:
    Med Chem. 2011 Jul;7(4):250-6.
    Norlichexanthone isolated from fungus P16 promotes the secretion and expression of adiponectin in cultured ST-13 adipocytes.[Pubmed: 21568875]

    METHODS AND RESULTS:
    We found that the butanol extract of a fungus P16 culture extract possessed such an activity, and isolated Norlichexanthone as an active compound through activity-guided fractionation. Oil red O staining showed that Norlichexanthone induced adipogenesis in ST-13 cells. Its differentiation-inducing activity was supported by the observation that Norlichexanthone dose-dependently increased the mRNA expression of fatty acid-binding protein and peroxisome proliferator activated receptor γ (PPARγ), markers of adipocyte differentiation. Western blot analysis demonstrated that the compound enhanced the secretion of adiponectin protein in a dose-dependent manner. An increase in mRNA expression of adiponectin was also observed in the Norlichexanthone-treated ST-13 cells. Actinomycin D treatment blocked the enhancement of adiponectin mRNA expression by Norlichexanthone, suggesting that it is the result of increased transcription. A luciferase reporter assay indicated that Norlichexanthone was unlikely to be an agonist of PPARγ, implying that its action of mechanism might differ from those of thiazolidinediones which upregulate adiponectin expression via activation of PPARγ.
    CONCLUSIONS:
    These findings suggest the possibility that Norlichexanthone has the potential to treat and/or prevent lifestyle-related diseases, including metabolic syndrome, type 2 diabetes, atherosclerosis and cardiovascular diseases.
    Appl Environ Microbiol. 2015 May 29.
    SnPKS19 encodes the polyketide synthase for alternariol mycotoxin biosynthesis in the wheat pathogen Parastagonospora nodorum.[Pubmed: 26025896]
    Alternariol (AOH) is an important mycotoxin from the Alternaria fungi. AOH was detected for the first time in the wheat pathogen Parastagonospora nodorum in a recent study.
    METHODS AND RESULTS:
    Here, we exploited reverse genetics to demonstrate that SNOG_15829 (SnPKS19), a close homolog of Penicillium aethiopicum norlichexanthone (NLX) synthase gene gsfA, is required for AOH production. We further validate that SnPKS19 is solely responsible for AOH production by heterologous expression in Aspergillus nidulans. The expression profile of SnPKS19 based on previous P. nodorum microarray data correlated with the presence of AOH in vitro and its absence in planta. Subsequent characterization of the ΔSnPKS19 mutants showed that SnPKS19 and AOH are not involved in virulence and oxidative stress tolerance. Identification and characterization of the P. nodorum SnPKS19 cast light on a possible alternative AOH synthase gene in Alternaria alternata and allowed us to survey the distribution of AOH synthase genes in other fungal genomes. We further demonstrate that phylogenetic analysis could be used to differentiate between AOH synthases and the closely related NLX synthases.
    CONCLUSIONS:
    This study provides the basis for studying the genetic regulation of AOH production and for development of molecular diagnostic methods for detecting AOH-producing fungi in the future.
    Fitoterapia. 2012 Jan;83(1):209-14.
    Polyketides with antimicrobial activity from the solid culture of an endolichenic fungus Ulocladium sp.[Pubmed: 22061662]

    METHODS AND RESULTS:
    Two new polyketides, 7-hydroxy-3, 5-dimethyl-isochromen-1-one (1) and 6-hydroxy-8-methoxy-3a-methyl-3a,9b-dihydro-3H-furo[3,2-c]isochromene-2,5-dione (2), along with eleven known compounds, 5'-methoxy-6-methyl-biphenyl-3,4,3'-triol (3), 7-hydroxy-3-(2-hydroxy-propyl)-5-methyl-isochromen-1-one (4), rubralactone (5), isoaltenuene (6), altenuene (7), dihydroaltenuenes A (8), altenusin (9), alterlactone (10), 6-O-methylNorlichexanthone (11), Norlichexanthone (12), and griseoxanthone C (13) were isolated from the culture of the endolichenic fungus Ulocladium sp. Compound 2 was obtained as a racemate with an unprecedented chemical skeleton. The NMR data assignments for 3 and 4 were achieved for the first time. Compounds 1-13 were screened for their antimicrobial and radical scavenging activities.
    CONCLUSIONS:
    Compound 1 showed some antifungal activity against Candida albicans SC 5314 with IC(50) of 97.93 ± 1.12 μM. Compounds 11-13 showed strong activity against Bacillus subtilis with IC(50) in the range of 1-5 μM. Compound 12 significantly inhibited the growth of methicillin-resistant Staphylococcus aureus with IC(50) of 20.95 ± 1.56 μM. Compounds 9 and 10 showed strong radical scavenging activity in comparison with vitamin C. The plausible biosynthetic pathways for compounds 1, 2, and 4-8 were discussed.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.873 mL 19.3648 mL 38.7297 mL 77.4593 mL 96.8242 mL
    5 mM 0.7746 mL 3.873 mL 7.7459 mL 15.4919 mL 19.3648 mL
    10 mM 0.3873 mL 1.9365 mL 3.873 mL 7.7459 mL 9.6824 mL
    50 mM 0.0775 mL 0.3873 mL 0.7746 mL 1.5492 mL 1.9365 mL
    100 mM 0.0387 mL 0.1936 mL 0.3873 mL 0.7746 mL 0.9682 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1,5,6-三羟基双苯吡酮; 1,5,6-Trihydroxyxanthone CFN89364 5042-03-5 C13H8O5 = 244.19 5mg QQ客服:2056216494
    1,5,6-三羟基-3-甲氧基呫吨酮; 1,5,6-Trihydroxy-3-methoxyxanthone CFN89549 50868-52-5 C14H10O6 = 274.22 5mg QQ客服:215959384
    1,3,6-Trihydroxy-2,5-dimethoxyxanthone; 1,3,6-Trihydroxy-2,5-dimethoxyxanthone CFN96911 345287-92-5 C15H12O7 = 304.25 5mg QQ客服:1457312923
    1,3,6-三羟基-2-甲氧基-8-甲基-9H-氧杂蒽-9-酮; Drimiopsin C CFN97257 773850-90-1 C15H12O6 = 288.3 5mg QQ客服:1413575084
    1,3,6-三羟基-4,5-二甲氧基-8-甲基-9H-氧杂蒽-9-酮; Drimiopsin D CFN97258 773850-91-2 C16H14O7 = 318.3 5mg QQ客服:2159513211
    3,6,8-三羟基-1-甲基呫吨酮; Norlichexanthone CFN98041 20716-98-7 C14H10O5 = 258.2 5mg QQ客服:1413575084
    Methyl 1,6-dihydroxy-3-methylxanthone-8-carboxylate; Methyl 1,6-dihydroxy-3-methylxanthone-8-carboxylate CFN89185 85003-85-6 C16H12O6 = 300.26 5mg QQ客服:1457312923
    枇杷呋喃; Eriobofuran CFN89145 97218-06-9 C14H12O4 = 244.24 5mg QQ客服:2159513211
    9-羟基枇杷呋喃; 9-Hydroxyeriobofuran CFN89153 167278-41-3 C14H12O5 = 260.24 5mg QQ客服:1457312923
    雏菊叶龙胆酮; Bellidifolin CFN89132 2798-25-6 C14H10O6 = 274.22 10mg QQ客服:1457312923

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