• 中药标准品生产商,产品定制服务
  • 努特卡酮, 诺卡酮

    Nootkatone

    努特卡酮, 诺卡酮
    产品编号 CFN98699
    CAS编号 4674-50-4
    分子式 = 分子量 C15H22O = 218.3
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Sesquiterpenoids
    植物来源 The rhizoma of Bupleurum longibrachiatum Turcz.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    努特卡酮, 诺卡酮 CFN98699 4674-50-4 10mg QQ客服:2159513211
    努特卡酮, 诺卡酮 CFN98699 4674-50-4 20mg QQ客服:2159513211
    努特卡酮, 诺卡酮 CFN98699 4674-50-4 50mg QQ客服:2159513211
    努特卡酮, 诺卡酮 CFN98699 4674-50-4 100mg QQ客服:2159513211
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Charles Sturt University (Denmark)
  • Donald Danforth Plant Science Center (USA)
  • University of British Columbia (Canada)
  • Tokyo Woman's Christian University (Japan)
  • National Cancer Institute (USA)
  • University of Malaya (Malaysia)
  • University of Maryland (USA)
  • Universidad Miguel Hernández (Spain)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • University of Lodz (Poland)
  • University of Canterbury (New Zealand)
  • Medical University of South Carolina (USA)
  • University of Wuerzburg (Germany)
  • University of the Basque Country (Spain)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Oncotarget.2015, 6(31):30831-49
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • Korean J. of Food Sci. and Tech2016, 172-177
  • The Korea Journal of Herbology2016, 29-35
  • Chemistry of Plant Materials.2016, 33-46
  • Industrial Crops and Products2017, 95:286-295
  • Molecules.2018, 23(7):E1817
  • International Food Research Journal2018, 25(6):2560-2571
  • Industrial Crops and Products2018, 353-362
  • Phytomedicine.2018, 38:12-23
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • Sci Rep.2018, 8:9267
  • Front Immunol.2018, 9:2655
  • Nat Commun.2019, 10(1):5169
  • Nutrients.2019, 12(1)
  • Plant Physiol Biochem.2019, 144:355-364
  • Int J Mol Sci.2019, 20(3):E651
  • Cell Chem Biol.2019, 26(1):27-34
  • Chem Biol Interact.2019, 298:1-7
  • FASEB J.2019, 33(2):2026-2036
  • Int J Oncol.2019, 55(1):320-330
  • Phytomedicine.2019, 65:153089
  • Food Sci Nutr.2019, 8(1):246-256
  • ...
  • 生物活性
    Description: Nootkatone, a naturally occurring AMPK activator, can stimulate energy metabolism and prevents diet-induced obesity by activating AMPK. (+)-Nootkatone has antiallergic, anti-inflammatory, antiproliferative, and antiplatelet activities. Nootkatone is a strong repellent and toxicant to Formosan subterranean termites, the lowest effective concentration tested is 10 micrograms/g substrate. (+)-Nootkatone has potent inhibitory effect on collagen-, thrombin-, and AA-induced platelet aggregation, it also has a significant inhibitory effect on rat platelet aggregation ex vivo.
    Targets: TNF-α | IFN-γ | NF-kB | p38MAPK | IkB | AMPK | Calcium Channel | Antifection | IKK
    In vitro:
    J Ethnopharmacol. 2011 Apr 26;135(1):48-54.
    Antiplatelet effects of Cyperus rotundus and its component (+)-nootkatone.[Pubmed: 21354294 ]
    Cyperus rotundus, a well-known oriental traditional medicine, has been reported to exhibit wide spectrum activity in biological systems including the circulatory system, however, little information is available on its antiplatelet activity. This study was undertaken to investigate the antiplatelet effects of Cyperus rotundus EtOH extract (CRE) and its constituent compounds.
    METHODS AND RESULTS:
    The antiplatelet activities of CRE and its eight constituent compounds were evaluated by examining their effects on rat platelet aggregations in vitro and ex vivo, and on mice tail bleeding times. During the in vitro platelet aggregation study, CRE showed significant and concentration-dependent inhibitory effects on collagen-, thrombin-, and/or AA-induced platelet aggregation. Of its eight components, (+)-nootkatone was found to have the most potent inhibitory effect on collagen-, thrombin-, and AA-induced platelet aggregation. In addition, CRE- and (+)-nootkatone-treated mice exhibited significantly prolonged bleeding times. Furthermore, (+)-nootkatone had a significant inhibitory effect on rat platelet aggregation ex vivo.
    CONCLUSIONS:
    This study demonstrates the antiplatelet effects of CRE and its active component (+)-nootkatone, and suggests that these agents might be of therapeutic benefit for the prevention of platelet-associated cardiovascular diseases.
    J Econ Entomol. 2009 Dec;102(6):2316-24.
    Ability of two natural products, nootkatone and carvacrol, to suppress Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) in a Lyme disease endemic area of New Jersey.[Pubmed: 20069863]
    We evaluated the ability of the natural, plant-derived acaricides nootkatone and carvacrol to suppress Ixodes scapularis Say and Amblyomma americanum (L.) (Acari: Ixodidae).
    METHODS AND RESULTS:
    Aqueous formulations of 1 and 5% nootkatone applied by backpack sprayer to the forest litter layer completely suppressed I. scapularis nymphs through 2 d. Thereafter, the level of reduction gradually declined to < or =50% at 28 d postapplication. Against A. americanum nymphs, 1% nootkatone was less effective, but at a 5% concentration, the level of control was similar or greater to that observed with I. scapularis through 21 d postapplication. Initial applications of 0.05% carvacrol were ineffective, but a 5% carvacrol formulation completely suppressed nymphs of both species through 2 d and resulted in significant reduction in I. scapularis and A. americanum nymphs through 28 and 14 d postapplication, respectively. Backpack sprayer applications of 5% nootkatone to the shrub and litter layers resulted in 100% control of I. scapularis adults through 6 d, but the level of reduction declined to 71.5% at 28 d postapplication. By contrast, high-pressure applications of 2% nootkatone to the litter layer resulted in 96.2-100% suppression of both I. scapularis and A. americanum nymphs through 42 d, whereas much lower control was obtained from the same formulation applied by backpack sprayer. Backpack sprayer application of a 3.1% nootkatone nanoemulsion resulted in 97.5-98.9 and 99.3-100% reduction in I. scapularis and A. americanum nymphs, respectively, at 1 d postapplication. Between 7 d and 35 d postapplication, the level of control varied between 57.1% and 92.5% for I. scapularis and between 78.5 and 97.1% for A. americanum nymphs.
    CONCLUSIONS:
    The ability of natural products to quickly suppress and maintain significant control of populations of these medically important ticks at relatively low concentrations may represent a future alternative to the use of conventional synthetic acaricides.
    J Chem Ecol. 2001 Mar;27(3):523-31.
    Nootkatone is a repellent for Formosan subterranean termite (Coptotermes formosanus).[Pubmed: 11441443]
    We examined the behavior of Formosan subterranean termites toward one of the components of vetiver grass oil, the roots of which manufacture insect repellents.
    METHODS AND RESULTS:
    We found nootkatone, a sesquiterpene ketone, isolated from vetiver oil is a strong repellent and toxicant to Formosan subterranean termites. The lowest effective concentration tested was 10 micrograms/g substrate.
    CONCLUSIONS:
    This is the first report of nootkatone being a repellent to insects.
    In vivo:
    Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E266-75.
    Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPK.[Pubmed: 20501876 ]
    AMP-activated protein kinase (AMPK) is a serine/threonine kinase that is implicated in the control of energy metabolism and is considered to be a molecular target for the suppression of obesity and the treatment of metabolic syndrome.
    METHODS AND RESULTS:
    Here, we identified and characterized nootkatone, a constituent of grapefruit, as a naturally occurring AMPK activator. Nootkatone induced an increase in AMPKalpha1 and -alpha2 activity along with an increase in the AMP/ATP ratio and an increase the phosphorylation of AMPKalpha and the downstream target acetyl-CoA carboxylase (ACC), in C(2)C(12) cells. Nootkatone-induced activation of AMPK was possibly mediated both by LKB1 and Ca(2+)/calmodulin-dependent protein kinase kinase. Nootkatone also upregulated PPARgamma coactivator-1alpha in C(2)C(12) cells and C57BL/6J mouse muscle. In addition, administration of nootkatone (200 mg/kg body wt) significantly enhanced AMPK activity, accompanied by LKB1, AMPK, and ACC phosphorylation in the liver and muscle of mice. Whole body energy expenditure evaluated by indirect calorimetry was also increased by nootkatone administration. Long-term intake of diets containing 0.1% to 0.3% (wt/wt) nootkatone significantly reduced high-fat and high-sucrose diet-induced body weight gain, abdominal fat accumulation, and the development of hyperglycemia, hyperinsulinemia, and hyperleptinemia in C57BL/6J mice. Furthermore, endurance capacity, evaluated as swimming time to exhaustion in BALB/c mice, was 21% longer in mice fed 0.2% nootkatone than in control mice.
    CONCLUSIONS:
    These findings indicate that long-term intake of nootkatone is beneficial toward preventing obesity and improving physical performance and that these effects are due, at least in part, to enhanced energy metabolism through AMPK activation in skeletal muscle and liver.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.5809 mL 22.9043 mL 45.8085 mL 91.617 mL 114.5213 mL
    5 mM 0.9162 mL 4.5809 mL 9.1617 mL 18.3234 mL 22.9043 mL
    10 mM 0.4581 mL 2.2904 mL 4.5809 mL 9.1617 mL 11.4521 mL
    50 mM 0.0916 mL 0.4581 mL 0.9162 mL 1.8323 mL 2.2904 mL
    100 mM 0.0458 mL 0.229 mL 0.4581 mL 0.9162 mL 1.1452 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    苷松新酮; Nardosinone CFN90178 23720-80-1 C15H22O3 = 250.33 20mg QQ客服:1148253675
    甘松香酮B ; Kanshone B CFN89423 115370-61-1 C15H22O4 = 266.33 5mg QQ客服:1148253675
    马兜铃酮; Aristolone CFN96139 6831-17-0 C15H22O = 218.3 20mg QQ客服:1413575084
    Axinysone B ; Axinysone B CFN89436 1114491-60-9 C15H22O2 = 234.33 5mg QQ客服:3257982914
    甘松香酮H; Kanshone H CFN89349 1445952-33-9 C15H20O = 216.31 5mg QQ客服:3257982914
    1(10)-Aristolen-2-one; 1(10)-Aristolen-2-one CFN89356 28398-06-3 C15H22O = 218.33 5mg QQ客服:1413575084
    Aristola-1(10),8-dien-2-one; Aristola-1(10),8-dien-2-one CFN89328 22391-34-0 C15H20O = 216.32 5mg QQ客服:1148253675
    Debilon; Debilon CFN89419 26808-51-5 C15H22O2 = 234.33 5 mg QQ客服:3257982914
    Nardoaristolone B; Nardoaristolone B CFN95203 1422517-82-5 C14H18O2 = 218.3 5mg QQ客服:3257982914
    甘松香酮 A; Kanshone A CFN96977 115356-18-8 C15H22O2 = 234.33 5mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 215959384
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产