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    产品编号 CFN90232
    CAS编号 495-31-8
    分子式 = 分子量 C20H24O9 = 408.40
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Coumarins
    植物来源 The roots of Angelica biserrata (Shan et Yuan) Yuan et Shan.
    产品名称 产品编号 CAS编号 包装 QQ客服
    紫花前胡苷 CFN90232 495-31-8 10mg QQ客服:1457312923
    紫花前胡苷 CFN90232 495-31-8 20mg QQ客服:1457312923
    紫花前胡苷 CFN90232 495-31-8 50mg QQ客服:1457312923
    紫花前胡苷 CFN90232 495-31-8 100mg QQ客服:1457312923
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  • 生物活性
    Description: Nodakenin acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84.7 μM. Nodakenin possesses neuroprotective, anti-allergic, antiaggregatory, antibacterial, and memory -enhancing effects. Nodakenin down-regulates the expression of the proinflammatory iNOS, COX-2, TNF-α, IL-6, and IL-1β genes in macrophages by interfering with the activation of TRAF6, thus preventing NF-κB activation.
    Targets: NOS | COX | TNF-α | IL Receptor | p65 | NF-kB | IkB | NO | PGE | Antifection | IKK | TRAF6 | AChR
    In vitro:
    J Pharmacol Exp Ther. 2012 Sep;342(3):654-64.
    Nodakenin suppresses lipopolysaccharide-induced inflammatory responses in macrophage cells by inhibiting tumor necrosis factor receptor-associated factor 6 and nuclear factor-κB pathways and protects mice from lethal endotoxin shock.[Pubmed: 22637723]
    Nodakenin, a coumarin isolated from the roots of Angelicae gigas, has been reported to possess neuroprotective, antiaggregatory, antibacterial, and memory-enhancing effects.
    In the present study, we investigated the anti-inflammatory effects of nodakenin by examining its in vitro inhibitory effects on inducible nitric-oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and proinflammatory cytokines in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and mouse peritoneal macrophages and its in vivo effects on LPS-induced septic shock in mice. Our results indicate that nodakenin concentration-dependently inhibits iNOS and COX-2 at the protein, mRNA, and promoter binding levels, and these inhibitions cause attendant decreases in the production of nitric oxide (NO) and prostaglandin E₂ (PGE₂). Furthermore, we found that nodakenin inhibits the production and mRNA expression of tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-1β induced by LPS. Molecular data revealed that nodakenin suppressed the transcriptional activity and translocation of nuclear factor-κB (NF-κB) by inhibiting inhibitory κB-α degradation and IκB kinase-α/β phosphorylation. In addition, nodakenin was found to significantly inhibit the LPS-induced binding of transforming growth factor-β-activated kinase 1 to tumor necrosis factor receptor-associated factor 6 (TRAF6) by reducing TRAF6 ubiquitination. Pretreatment with nodakenin reduced the serum levels of NO, PGE₂, and proinflammatory cytokines and increased the survival rate of mice with LPS-induced endotoxemia.
    Taken together, our data suggest that nodakenin down-regulates the expression of the proinflammatory iNOS, COX-2, TNF-α, IL-6, and IL-1β genes in macrophages by interfering with the activation of TRAF6, thus preventing NF-κB activation.
    In vivo:
    Immunopharmacol Immunotoxicol. 2014 Oct;36(5):341-8.
    The effects of nodakenin on airway inflammation, hyper-responsiveness and remodeling in a murine model of allergic asthma.[Pubmed: 25090633]
    Nodakenin is a major coumarin glucoside in the root of Peucedanum decursivum Maxim, a commonly used traditional Chinese medicine for the treatment of asthma and chronic bronchitis for thousands of years. In this work, the anti-asthma potential of nodakenin was studied by investigation of its effect to suppress airway inflammation, hyper-responsiveness and remodeling in a murine model of chronic asthma.
    BALB/c mice sensitized to ovalbumin (OVA) were challenged with aerosolized OVA for 8 weeks, orally administered with nodakenin at doses of 5, 10 and 20 mg/kg before each OVA challenge. Compared with the model group, nodakenin treatment markedly inhibited airway inflammation, hyper-responsiveness and remodeling, showing improvement in subepithelial fibrosis, smooth muscle hypertrophy, and goblet cell hyperplasia, and decreased levels of interleukin (IL)-4, IL-5, IL-13 and matrix metalloproteinase-2/-9 in bronchoalveolar lavage fluid, and the level of OVA-specific IgE in serum. In addition, the NF-κB DNA-binding activity in lung tissues was also reduced by nodakenin treatment.
    These data indicated that nodakenin might mitigate the development of chronic experimental allergic asthma.
    Life Sci. 2007 May 1;80(21):1944-50.
    Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice.[Pubmed: 17382968 ]
    Nodakenin is a coumarin compound initially isolated from the roots of Angelica gigas.
    In the present study, we investigated the effects of nodakenin on learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) using the passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Nodakenin (10 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in the passive avoidance test and the Y-maze test (P<0.05), and also reduced escape latency during training in the Morris water maze test (P<0.05). Moreover, swimming times and distances within the target zone of the Morris water maze were greater in the nodakenin-treated group than in the scopolamine-treated group (P<0.05). In an in vitro study, nodakenin was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC(50)=84.7 microM). In addition, nodakenin was also found to inhibit acetylcholinesterase activity for 6 h in an ex-vivo study.
    These results suggest that nodakenin may be a useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, via the enhancement of cholinergic signaling.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4486 mL 12.2429 mL 24.4858 mL 48.9716 mL 61.2145 mL
    5 mM 0.4897 mL 2.4486 mL 4.8972 mL 9.7943 mL 12.2429 mL
    10 mM 0.2449 mL 1.2243 mL 2.4486 mL 4.8972 mL 6.1214 mL
    50 mM 0.049 mL 0.2449 mL 0.4897 mL 0.9794 mL 1.2243 mL
    100 mM 0.0245 mL 0.1224 mL 0.2449 mL 0.4897 mL 0.6121 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    芸香霉素,芸香亭; Rutaretin CFN97825 13895-92-6 C14H14O5 = 262.26 5mg QQ客服:2159513211
    前胡香豆精 G; Qianhucoumarin G CFN92800 68692-61-5 C14H14O5 = 262.3 5mg QQ客服:1457312923
    闹达柯裂亭; Nodakenetin CFN98788 495-32-9 C14H14O4 = 246.3 10mg QQ客服:3257982914
    异紫花前胡内酯异戊烯酸酯; Isopropylidenylacetyl-marmesin CFN90887 35178-20-2 C19H20O5 = 328.4 20mg QQ客服:2056216494
    异紫花前胡素当归酯; Marmesin angelate CFN80120 13209-79-5 C19H20O5 = 328.36 5mg QQ客服:2056216494
    Ammijin; Ammijin CFN92711 495-30-7 C20H24O9 = 408.4 5mg QQ客服:2056216494
    紫花前胡苷; Nodakenin CFN90232 495-31-8 C20H24O9 = 408.40 20mg QQ客服:2056216494
    6'-O-(反式阿魏酰基)-紫花前胡苷; 6'-Feruloylnodakenin CFN95202 131623-14-8 C30H32O12 = 584.6 10mg QQ客服:1457312923
    紫花前胡苷I; Decuroside I CFN95004 96638-79-8 C26H34O14 = 570.6 5mg QQ客服:3257982914
    1'-O-Beta-D-吡喃葡萄糖基-3-羟基闹达柯裂亭; Smyrindioloside CFN97442 87592-77-6 C20H24O10 = 424.4 10mg QQ客服:2932563308





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