水仙苷

Narcissoside

	产品编号	CFN99773
	CAS编号	604-80-8
	分子式 = 分子量	C₂₈H₃₂O₁₆ = 624.54
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The bulbus of Narcissus tazettaL. var. chinensis Roem.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
水仙苷	CFN99773	604-80-8	10mg	QQ客服：1413575084
水仙苷	CFN99773	604-80-8	20mg	QQ客服：1413575084
水仙苷	CFN99773	604-80-8	50mg	QQ客服：1413575084
水仙苷	CFN99773	604-80-8	100mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universiti Putra Malaysia(UPM) (Malaysia)

University of Padjajaran (Indonesia)

Istanbul University (Turkey)

University of Bonn (Germany)

Heinrich-Heine-University Düsseldorf (Germany)

Aveiro University (Portugal)

Agricultural Research Organization (ARO) (Israel)

Research Unit Molecular Epigenetics (MEG) (Germany)

University of Lodz (Poland)

University of Madras (India)

Kazusa DNA Research Institute (Japan)

University of Melbourne (Australia)

Institute of Pathophysiology Medical University of Vienna (Austria)

Kyoto University (Japan)

More...

Description:

Narcissoside is a good 15-LO and α-glucosidase inhibitor, it with synergism of B.flavum flavonoid and rutin, could be responsible for stronger protection against mitochondrial induced oxidative stress.

Targets:

AMPK | α-Glucosidase | 15-lipoxygenase

In vitro:

Pharmacogn Mag. 2015 Jan-Mar;11(41):14-23.

Flavonoid profiles of three Bupleurum species and in vitro hepatoprotective of activity Bupleurum flavum Forsk.[Pubmed: 25709205]

Bupleurum L. (Aspiaceae) species are used as herbal remedy in Chinese traditional medicine. OBJECTIVE: The aim was to investigate the flavonoids in three annual European Bupleurum species, including B. baldense, B. affine and B. flavum, and to test their antioxidant and possible hepatoprotective effects.
METHODS AND RESULTS:
Flavonoids from the methanol-aqueous extracts were quantified by solid-phase extraction-high-performance liquid chromatography. Bupleurum extracts (1-220 mg/ml) were tested for their antioxidant activity in DPPH and ABTS assays, as well as on isolated liver rat microsomes. In vitro hepatoprotective activity of B. flavum flavonoid (BFF) mixture and rutin, and Narcissoside, isolated from the same mixture, were evaluated on carbon tetrachloride (CCl4) and tert-butyl hydroperoxide (t-BuOOH) toxicity models in isolated rat hepatocytes. Narcissoside was the dominant flavonol glycoside in B. flavum being present at 24.21 ± 0.19 mg/g, whilst the highest content of rutin (28.63 ± 1.57 mg/g) was found in B. baldense. B. flavum possessed the strongest DPPH (IC50 22.12 μg/ml) and ABTS (IC50 118.15 μg/ml) activity. At a concentration 1 mg/ml of BFF (rutin 197.58 mg/g, narcissin 75.74 mg/g), a stronger antioxidant effect in microsomes was evidenced in comparison with silymarin, rutin and Narcissoside. The hepatoprotective effect of BFF significantly reduced the elevated levels of lactate dehydrogenase and malondialdehyde, and ameliorated glutathione, being most active in t-BuOOH-induced injury model when compared with CCl4 toxicity (P < 0.001).
CONCLUSIONS:
In BFF, synergism of rutin and Narcissoside could be responsible for stronger protection against mitochondrial induced oxidative stress.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
柽柳黄素 7-O-新橙皮糖苷; Tamarixetin 7-O-neohesperidoside	CFN91527	28283-76-3	C₂₈H₃₂O₁₆ = 624.6	5mg	QQ客服：2056216494
异鼠李素-7-O-葡萄糖苷; Isorhamnetin 7-O-glucoside	CFN91115	6743-96-0	C₂₂H₂₂O₁₂ = 478.4	5mg	QQ客服：3257982914
异鼠李素-3-O-葡萄糖-7-O-鼠李糖苷; Isorhamnetin 3-glucoside-7-rhamnoside	CFN90739	17331-71-4	C₂₈H₃₂O₁₆ = 624.54	5mg	QQ客服：215959384
异鼠李素-3,7-O-二葡萄糖苷; Isorhamnetin 3,7-O-diglucoside	CFN91130	6758-51-6	C₂₈H₃₂O₁₇ = 640.6	5mg	QQ客服：215959384
异鼠李素-3-O-芸香苷-7-O-葡萄糖苷; Isorhamnetin-3-O-rutinoside-7-O-glucoside	CFN95494	55481-91-9	C₃₄H₄₂O₂₁ = 786.7	5mg	QQ客服：3257982914
异鼠李素-3-O-β-D-葡萄糖-7-O-β-D-龙胆双糖苷; Isorhamnetin 3-O-beta-D-glucose-7-O-beta-D-gentiobioside	CFN91845	60778-00-9	C₃₄H₄₂O₂₂ = 802.7	5mg	QQ客服：215959384
异鼠李素-3-O-槐二糖-7-O-鼠李糖苷; Isorhamnetin 3-sophoroside-7-rhamnoside	CFN90735	41328-75-0	C₃₄H₄₂O₂₁ = 786.68	5mg	QQ客服：215959384
柠檬黄素-3-O-β-D-葡萄糖苷; Limocitrin 3-O-beta-D-glucopyranoside	CFN91697	38836-51-0	C₂₃H₂₄O₁₃ = 508.4	5mg	QQ客服：1457312923
柠檬黄素-3-O-芸香糖苷; Limocitrin-3-O-rutinoside	CFN91693	79384-27-3	C₂₉H₃₄O₁₇ = 654.6	5mg	QQ客服：1413575084
异鼠李素 3-O-半乳糖苷; Isorhamnetin 3-O-galactoside	CFN93036	6743-92-6	C₂₂H₂₂O₁₂ = 478.40	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6012 mL	8.0059 mL	16.0118 mL	32.0236 mL	40.0295 mL
5 mM	0.3202 mL	1.6012 mL	3.2024 mL	6.4047 mL	8.0059 mL
10 mM	0.1601 mL	0.8006 mL	1.6012 mL	3.2024 mL	4.0029 mL
50 mM	0.032 mL	0.1601 mL	0.3202 mL	0.6405 mL	0.8006 mL
100 mM	0.016 mL	0.0801 mL	0.1601 mL	0.3202 mL	0.4003 mL