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  • 桑皮苷F

    Mulberroside F

    桑皮苷F
    产品编号 CFN90794
    CAS编号 193483-95-3
    分子式 = 分子量 C26H30O14 = 566.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The root barks of Morus alba L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    桑皮苷F CFN90794 193483-95-3 1mg QQ客服:2056216494
    桑皮苷F CFN90794 193483-95-3 5mg QQ客服:2056216494
    桑皮苷F CFN90794 193483-95-3 10mg QQ客服:2056216494
    桑皮苷F CFN90794 193483-95-3 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    doi: 10.1021/acsnano.7b08969.
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    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
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  • Biomolecules.2019, 9(11):E696
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  • ...
  • 生物活性
    Description: Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells, it also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation, suggests that mulberroside F may be used as a skin whitening agent.
    Targets: Tyrosinase
    In vitro:
    Biol Pharm Bull. 2002 Aug;25(8):1045-8.
    Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis.[Pubmed: 12186407]

    METHODS AND RESULTS:
    The current study was carried out to investigate the in vitro effects of an 85% methanol extract of dried Morus alba leaves on melanin biosynthesis, which is closely related to hyperpigmentation. These extracts inhibited the tyrosinase activity that converts dopa to dopachrome in the biosynthetic process of melanin. Mulberroside F (moracin M-6, 3'-di-O-beta-D-glucopyranoside), which was obtained after the bioactivity-guided fractionation of the extracts, showed inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells. This compound also exhibited superoxide scavenging activity that is involved in the protection against auto-oxidation. But its activity was low and was weaker than of kojic acid.
    CONCLUSIONS:
    These results suggest that mulberroside F isolated from mulberry leaves might be used as a skin whitening agent.
    J Agric Food Chem . 2012 Mar 7;60(9):2299-308.
    In vitro pharmacokinetic characterization of mulberroside A, the main polyhydroxylated stilbene in mulberry (Morus alba L.), and its bacterial metabolite oxyresveratrol in traditional oral use[Pubmed: 22225542]
    Abstract Mulberroside A (MulA) is one of the main bioactive constituents in mulberry (Morus alba L.). This study examined the determining factors for previously reported oral pharmacokinetic profiles of MulA and its bacterial metabolite oxyresveratrol (OXY) on in vitro models. When incubated anaerobically with intestinal bacteria, MulA underwent rapid deglycosylation and generated two monoglucosides and its aglycone OXY sequentially. MulA exhibited a poor permeability and predominantly traversed Caco-2 cells via passive diffusion; yet, the permeation of OXY across Caco-2 cells was much more rapid and involved efflux (both p-glycoprotein and MRPs)-mediated mechanisms. Moreover, OXY underwent extensive hepatic glucuronidation; yet, the parent MulA was kept intact in liver subcellular preparations. There was insignificant species difference in intestinal bacterial conversion of MulA and the extent of OXY hepatic glucuronidation between humans and rats, while OXY exhibited a distinct positional preference of glucuronidation in the two species. Overall, these findings revealed a key role of intestinal bacterial conversion in absorption and systemic exposure of MulA and its resultant bacterial metabolite OXY in oral route in humans and rats and warranted further investigational emphasis on OXY and its hepatic metabolites for understanding the benefits of mulberry.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7652 mL 8.8261 mL 17.6523 mL 35.3045 mL 44.1306 mL
    5 mM 0.353 mL 1.7652 mL 3.5305 mL 7.0609 mL 8.8261 mL
    10 mM 0.1765 mL 0.8826 mL 1.7652 mL 3.5305 mL 4.4131 mL
    50 mM 0.0353 mL 0.1765 mL 0.353 mL 0.7061 mL 0.8826 mL
    100 mM 0.0177 mL 0.0883 mL 0.1765 mL 0.353 mL 0.4413 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    桑辛素 M; Moracin M CFN92327 56317-21-6 C14H10O4 = 242.2 5mg QQ客服:2159513211
    桑皮苷F; Mulberroside F CFN90794 193483-95-3 C26H30O14 = 566.5 10mg QQ客服:2159513211
    Gnetucleistol C; Gnetucleistol C CFN92438 864763-61-1 C15H12O4 = 256.3 5mg QQ客服:215959384
    买麻藤素M; Gnetifolin M CFN92437 439900-84-2 C15H12O4 = 256.3 5mg QQ客服:2159513211
    Wittifuran X; Wittifuran X CFN97922 1309478-07-6 C15H12O5 = 272.3 5mg QQ客服:2056216494

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