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  • 桑辛素 O

    Moracin O

    桑辛素 O
    产品编号 CFN96102
    CAS编号 123702-97-6
    分子式 = 分子量 C19H18O5 = 326.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The root barks of Morus alba L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    桑辛素 O CFN96102 123702-97-6 1mg QQ客服:215959384
    桑辛素 O CFN96102 123702-97-6 5mg QQ客服:215959384
    桑辛素 O CFN96102 123702-97-6 10mg QQ客服:215959384
    桑辛素 O CFN96102 123702-97-6 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • The Ohio State University (USA)
  • University of Amsterdam (Netherlands)
  • Universitas islam negeri Jakarta (Indonesia)
  • The Australian National University (Australia)
  • Chungnam National University (Korea)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • University of Hertfordshire (United Kingdom)
  • Kyoto University (Japan)
  • Universidade Católica Portuguesa (Portugal)
  • University of Medicine and Pharmacy (Romania)
  • Universidad de Antioquia (Colombia)
  • University of Beira Interior (Portugal)
  • Massachusetts General Hospital (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pak J Pharm Sci.2023, 36(1):51-57.
  • Nat Plants.2016, 3:16205
  • Pharmaceutics.2022, 14(5):945.
  • JOTCSA.2023, 10(4); 893-902.
  • Drug Des Devel Ther.2023, 17:2461-2479.
  • Clin Transl Oncol.2019, 10.1007
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • Food Science and Biotechnology2022, 10.1007.
  • Acta Chromatographica2016, 29(3)
  • Phytomedicine.2018, 38:12-23
  • Antioxidants (Basel).2021, 10(9):1487.
  • Industrial Crops and Products2022, 188:115596.
  • Heliyon.2023, e12778.
  • Int J Mol Sci.2022, 23(11):6172.
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Drug Des Devel Ther.2020, 14:969-976.
  • Sci Rep.2018, 8(1)
  • Acta Physiologiae Plantarum2015, 37:1736
  • J Formos Med Assoc.2020, S0929-6646(20)30425-3
  • Analytical Letters.2020, doi 10.1008
  • Applied Biological Chemistry2020, 63:37.
  • J Nat Prod.2018, 81(4):966-975
  • Natural Product Communications2023, 18(9).
  • ...
  • 生物活性
    Description: Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9c2 cells with the EC50 value of 4.5 ± 1.3 uM. Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia.
    Targets: HIF
    In vitro:
    Phytochemistry. 2017 Mar;135:128-134.
    Phenolic constituents from the root bark of Morus alba L. and their cardioprotective activity in vitro.[Pubmed: 27974159 ]

    METHODS AND RESULTS:
    A flavanone C-glycoside, steppogenin-5'-C-β-D-glucopyranoside, six prenylated 2-arylbenzofuran derivatives, Moracin O-3″-O-β-D-glucopyranoside, Moracin O-3'-O-β-D-xylopyranoside, moracin P-2″-O-β-D-glucopyranoside, moracin P-3'-O-β-D-glucopyranoside, moracin P-3'-O-α-L-arabinopyranoside and moracin P-3'-O-[β-D-glucopyranosyl-(1 → 2)]-α-L-arabinopyranoside, two phenolic acids, 2,4-dihydroxy-5-(4-hydroxybenzyl) benzoic acid and 2,4-dihydroxy-5-(3,4-dihydroxybenzyl) benzoic acid, as well as three known compounds, moracinoside C, Moracin O, and moracin P were isolated from the root bark of Morus alba L. Their structures were ascertained on the basis of spectroscopic evidence. The protective effects of the compounds against doxorubicin-induced cardiomyopathy in H9c2 cells was investigated in vitro.
    CONCLUSIONS:
    Of all of the isolated compounds, moracin P-3'-O-β-D-glucopyranoside, Moracin O and moracin P had a strong protective influence against doxorubicin-induced cell death with EC50 values of 9.5 ± 2.6, 4.5 ± 1.3, and 8.8 ± 2.4 μM, respectively.
    Molecules. 2017 Feb 8;22(2).
    Bioactive Benzofuran Derivatives from Cortex Mori Radicis, and Their Neuroprotective and Analgesic Activities Mediated by mGluR₁.[Pubmed: 28208727 ]
    Four new benzofuran-type stilbene glycosides and 14 known compounds including 8 benzofuran-type stilbenes and 6 flavonoids were isolated from the traditional Chinese medicine, Cortex Mori Radicis.
    METHODS AND RESULTS:
    The new compounds were identified as (9R)-moracin P 3'-O-α-l-arabinopyranoside (1), (9R)-moracin P 9-O-β-d-glucopyranoside (2), (9R)-moracin P 3'-O-β-d-glucopyranoside (3), and (9R)-Moracin O 10-O-β-d-glucopyranoside (4) based on the spectroscopic interpretation and chemical analysis. Three benzofuran-type stilbenes, Moracin O (5), R (7), and P (8) showed significant neuroprotective activity against glutamate-induced cell death in SK-N-SH cells. In addition, Moracin O (5) and P (8) also demonstrated a remarkable inhibition of the acetic acid-induced pain.
    CONCLUSIONS:
    The molecular docking with metabotropic glutamate receptor 1 (mGluR₁) results indicated that these neuroprotective benzofuran-type stilbenes might be the active analgesic components of the genus Morus, and acted by mediating the mGluR₁ pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0637 mL 15.3186 mL 30.6373 mL 61.2745 mL 76.5931 mL
    5 mM 0.6127 mL 3.0637 mL 6.1275 mL 12.2549 mL 15.3186 mL
    10 mM 0.3064 mL 1.5319 mL 3.0637 mL 6.1275 mL 7.6593 mL
    50 mM 0.0613 mL 0.3064 mL 0.6127 mL 1.2255 mL 1.5319 mL
    100 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.6127 mL 0.7659 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    高黄绿桑; Chlorophorin CFN92323 537-41-7 C24H28O4 = 380.5 5mg QQ客服:1413575084
    桑呋喃A; Mulberrofuran A CFN92772 68978-04-1 C25H28O4 = 392.5 5mg QQ客服:3257982914
    桑辛素 C; Moracin C CFN97178 69120-06-5 C19H18O4 = 310.4 5mg QQ客服:215959384
    5-(6-羟基-2-苯并呋喃基)-2-[(1E)-3-甲基-1-丁烯-1-基]-1,3-苯二醇; 5-(6-Hydroxybenzofuran-2-yl)-2-(3-methylbut-1-enyl)benzene-1,3-diol CFN97507 936006-11-0 C19H18O4 = 310.4 5mg QQ客服:1457312923
    桑辛素 D; Moracin D CFN97179 69120-07-6 C19H16O4 = 308.3 5mg QQ客服:1413575084
    桑辛素 T; Moracin T CFN92326 1146113-27-0 C20H20O5 = 340.4 5mg QQ客服:2056216494
    桑辛素 P; Moracin P CFN92324 102841-46-3 C19H18O5 = 326.4 5mg QQ客服:2056216494
    桑皮苷C; Mulberroside C CFN99587 102841-43-0 C24H26O9 = 458.46 20mg QQ客服:1457312923
    桑辛素 O; Moracin O CFN96102 123702-97-6 C19H18O5 = 326.4 5mg QQ客服:3257982914
    桑呋喃H; Mulberrofuran H CFN92414 89199-99-5 C27H22O6 = 442.5 5mg QQ客服:3257982914

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