蜂蜜曲菌素

Mellein

	产品编号	CFN97913
	CAS编号	480-33-1
	分子式 = 分子量	C₁₀H₁₀O₃ = 178.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Coumarins
	植物来源	The herbs of Goniothalamus griffithii
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
蜂蜜曲菌素	CFN97913	480-33-1	1mg	QQ客服：1457312923
蜂蜜曲菌素	CFN97913	480-33-1	5mg	QQ客服：1457312923
蜂蜜曲菌素	CFN97913	480-33-1	10mg	QQ客服：1457312923
蜂蜜曲菌素	CFN97913	480-33-1	20mg	QQ客服：1457312923

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Periyar University (India)

Helmholtz Zentrum München (Germany)

Utrecht University (Netherlands)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Universidad de Ciencias y Artes de Chiapas (Mexico)

Chulalongkorn University (Thailand)

Universidade Católica Portuguesa (Portugal)

University of Vigo (Spain)

Martin Luther University of Halle-Wittenberg (Germany)

Florida International University (USA)

Yale University (USA)

Universidad Miguel Hernández (Spain)

Mendel University in Brno (Czech Republic)

The Vancouver Prostate Centre (VPC) (Canada)

More...

Description:

Standard reference

In vitro:

Appl Environ Microbiol. 2015 Jan;81(1):177-86.

An in planta-expressed polyketide synthase produces (R)-mellein in the wheat pathogen Parastagonospora nodorum.[Pubmed: 25326302 ]

Parastagonospora nodorum is a pathogen of wheat that affects yields globally.
METHODS AND RESULTS:
Previous transcriptional analysis identified a partially reducing polyketide synthase (PR-PKS) gene, SNOG_00477 (SN477), in P. nodorum that is highly upregulated during infection of wheat leaves. Disruption of the corresponding SN477 gene resulted in the loss of production of two compounds, which we identified as (R)-mellein and (R)-O-methylmellein. Using a Saccharomyces cerevisiae yeast heterologous expression system, we successfully demonstrated that SN477 is the only enzyme required for the production of (R)-mellein. This is the first identification of a fungal PKS that is responsible for the synthesis of (R)-mellein. The P. nodorum ΔSN477 mutant did not show any significant difference from the wild-type strain in its virulence against wheat. However, (R)-mellein at 200 μg/ml inhibited the germination of wheat (Triticum aestivum) and barrel medic (Medicago truncatula) seeds. Comparative sequence analysis identified the presence of mellein synthase (MLNS) homologues in several Dothideomycetes and two sodariomycete genera.
CONCLUSIONS:
Phylogenetic analysis suggests that the MLNSs in fungi and bacteria evolved convergently from fungal and bacterial 6-methylsalicylic acid synthases.

J Am Chem Soc. 2012 Jul 25;134(29):11924-7.

Synthesis of (R)-mellein by a partially reducing iterative polyketide synthase.[Pubmed: 22793256]

Disruption of the corresponding SN477 gene resulted in the loss of production of two compounds, which we identified as (R)-Mellein and (R)-O-methylMellein.
METHODS AND RESULTS:
Using a Saccharomyces cerevisiae yeast heterologous expression system, we successfully demonstrated that SN477 is the only enzyme required for the production of (R)-Mellein. This is the first identification of a fungal PKS that is responsible for the synthesis of (R)-Mellein. The P. nodorum ΔSN477 mutant did not show any significant difference from the wild-type strain in its virulence against wheat. However, (R)-Mellein at 200 μg/ml inhibited the germination of wheat (Triticum aestivum) and barrel medic (Medicago truncatula) seeds. Comparative sequence analysis identified the presence of Mellein synthase (MLNS) homologues in several Dothideomycetes and two sodariomycete genera.
CONCLUSIONS:
Phylogenetic analysis suggests that the MLNSs in fungi and bacteria evolved convergently from fungal and bacterial 6-methylsalicylic acid synthases.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
异西瑞香素 B; Isodaphnoretin B	CFN96604	944824-29-7	C₂₀H₁₄O₈ = 382.32	5mg	QQ客服：215959384
异双七叶内酯;异千金子素; Isoeuphorbetin	CFN95207	50677-55-9	C₁₈H₁₀O₈ = 354.3	5mg	QQ客服：1413575084
Triumbelletin; Triumbelletin	CFN96473	131559-54-1	C₂₇H₁₄O₉ = 482.39	5mg	QQ客服：1413575084
蜂蜜曲菌素; Mellein	CFN97913	480-33-1	C₁₀H₁₀O₃ = 178.2	5mg	QQ客服：1457312923
飞龙掌血香豆醌; Toddacoumaquinone	CFN92734	142878-03-3	C₂₃H₁₈O₇ = 406.4	5mg	QQ客服：215959384
Aflavarin; Aflavarin	CFN89117	144429-67-4	C₂₄H₂₂O₉ = 454.43	5mg	QQ客服：1413575084
松风草内酯; Matsukaze-lactone	CFN89298	3153-73-9	C₂₀H₁₄O₆ = 350.32	5mg	QQ客服：1457312923
7-甲氧基-4-甲基香豆素; 7-Methoxy-4-methylcoumarin	CFN94405	2555-28-4	C₁₁H₁₀O₃ = 190.20	20mg	QQ客服：1413575084
6-甲氧基-4-甲基香豆素; 6-Methoxy-4-methylcoumarin	CFN94425	6295-35-8	C₁₁H₁₀O₃ = 190.20	20mg	QQ客服：2159513211
4,6-二甲氧基-2H-1-苯并吡喃-2-酮; 4,6-Dimethoxy-2H-1-benzopyran-2-one	CFN92538	53666-78-7	C₁₁H₁₀O₄ = 206.2	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.6117 mL	28.0584 mL	56.1167 mL	112.2334 mL	140.2918 mL
5 mM	1.1223 mL	5.6117 mL	11.2233 mL	22.4467 mL	28.0584 mL
10 mM	0.5612 mL	2.8058 mL	5.6117 mL	11.2233 mL	14.0292 mL
50 mM	0.1122 mL	0.5612 mL	1.1223 mL	2.2447 mL	2.8058 mL
100 mM	0.0561 mL	0.2806 mL	0.5612 mL	1.1223 mL	1.4029 mL

蜂蜜曲菌素

Mellein

信息支持

联系方式