| Description: |
Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α in hypoxic HeLa cells.Matairesinol has anti-osteoporotic activity via p38/ERK-NFATc1 signaling, but not by way of anti-resorptive action. Matairesinol could markedly benefit TRAIL-based tumor therapies, including those aimed at prostate cancer. |
| Targets: |
ROS | ATPase | p38MAPK | ERK | Akt | PI3K |
| In vitro: |
| Oncogene. 2010 Feb 11;29(6):898-908. | | Inhibition of Akt signaling by the lignan matairesinol sensitizes prostate cancer cells to TRAIL-induced apoptosis.[Pubmed: 19935713] | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to be selectively pro-apoptotic in cancer cells, with minimal toxicity to normal tissues.
Although this feature makes TRAIL a promising anticancer agent, not all cancer cell types are sensitive to TRAIL-induced apoptosis despite abundant expression of TRAIL receptors. Thus, combinatorial treatments to sensitize tumor cells to TRAIL-induced apoptosis have been in the focus of extensive research. Dietary lignans have shown cancer preventive and antitumorigenic activity, but the mechanisms behind these effects are poorly known.
METHODS AND RESULTS:
Here we observed that of the three tested lignan molecules, matairesinol (MAT) was the most effective as a death receptor-sensitizing agent. MAT sensitized the androgen-dependent LNCaP cells to TRAIL-induced apoptosis both in the presence and absence of androgens. Treatment with MAT markedly decreased Akt activity, which has been implicated as a key signaling mechanism in the TRAIL resistance of LNCaP prostate cancer cells.
The involvement of the pathway in the MAT-mediated sensitization was shown in rescue experiments using ectopic expression of constitutively active Akt.
CONCLUSIONS:
Owing to the high activity of phosphatidylinositol 3-kinase/Akt signaling in cancer, targeting this survival pathway with MAT could markedly benefit TRAIL-based tumor therapies, including those aimed at prostate cancer. | | Biosci Biotechnol Biochem. 2006 Aug;70(8):1934-40. | | Radical and superoxide scavenging activities of matairesinol and oxidized matairesinol.[Pubmed: 16926506] | The radical and superoxide scavenging activities of oxidized Matairesinols were examined.
METHODS AND RESULTS:
It could be assumed that the free benzylic position was important for higher radical scavenging activity. The different level of activity was observed between 7'-oxoMatairesinol (Mat 2) and 7-oxoMatairesinol (Mat 3). The activity of 8-hydroxyMatairesinol was lower than that of Matairesinol (Mat 1).
CONCLUSIONS:
The superoxide scavenging activity of the oxidized Matairesinols was also demonstrated for the first time. It is assumed that the pKa value of phenol in the oxidized Matairesinols affected this activity. |
|
| In vivo: |
| J Ethnopharmacol . 2016 Jul 1;187:49-56. | | Forsythia suspensa fruit extracts and the constituent matairesinol confer anti-allergic effects in an allergic dermatitis mouse model[Pubmed: 27085937] | | Abstract
Ethnopharmacological relevance: Forsythia suspensa is used in traditional medicine to treat inflammation. To clarify the anti-inflammatory and anti-allergic effects of F. suspensa fruits, we determined the therapeutic effects of crude extract, fractions, and a constituent from F. suspensa fruits on a murine atopic dermatitis (AD) model.
Materials and methods: We investigated the inhibitory effects of F. suspensa extract (FSE), extract fractions, and the constituent matairesinol on histamine release from MC/9 mast cells activated by compound 48/80 and the development of AD-like skin lesions and symptoms in NC/Nga mice exposed to Dermatophagoides farinae (mite) extract. High performance liquid chromatography (HPLC) analysis of FSE and its fractions were evaluated using matairesinol standard.
Results: FSE, FSE methylene chloride fraction (FSE-MC), and FSE water fraction (FSE-water) inhibited compound 48/80-induced histamine release from MC/9 mast cells. Topical application of FSE or FSE-MC to NC/Nga mice exposed to Dermatophagoides farinae suppressed the development of AD-like skin lesions. Quantitative HPLC analysis of FSE and FSE-MC identified the presence of matairesinol. Topical application of matairesinol to NC/Nga mice effectively reduced AD symptoms, inhibited inflammatory cell infiltration, and lowered immunoglobulin E levels in serum. Further study demonstrated that DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application.
Conclusions: These results indicate that the F. suspensa and its constituent matairesinol might be a therapeutic candidate for treating allergic inflammatory disorders such as AD.
Keywords: Anti-allergic; Anti-inflammatory; Forsythia suspensa; Histamine; Mast cells; Matairesinol. |
|
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)
