氯化锦葵色素-3-O-葡萄糖苷

Malvidin-3-O-glucoside chloride

	产品编号	CFN92049
	CAS编号	7228-78-6
	分子式 = 分子量	C₂₃H₂₅ClO₁₂ = 528.9
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The fruits of Vaccinium myrtillus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
氯化锦葵色素-3-O-葡萄糖苷	CFN92049	7228-78-6	1mg	QQ客服：3257982914
氯化锦葵色素-3-O-葡萄糖苷	CFN92049	7228-78-6	5mg	QQ客服：3257982914
氯化锦葵色素-3-O-葡萄糖苷	CFN92049	7228-78-6	10mg	QQ客服：3257982914
氯化锦葵色素-3-O-葡萄糖苷	CFN92049	7228-78-6	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Malvidin 3-glucoside has antioxidant activity, alone is not oxidized in the presence of grape polyphenol oxidase. Malvidin 3-glucoside's color stabilization at a higher pH can be explained by self-aggregation of the flavylium cation and copigmentation with the Z-chalcone form.

In vitro:

J Food Biochem. 2008 Sep 23;32(5):576-596.

Anthocyanin Interactions with DNA: Intercalation, Topoisomerase I Inhibition and Oxidative Reactions.[Pubmed: 19924259]

Anthocyanins and their aglycone anthocyanidins are pigmented flavonoids found in significant amounts in many commonly consumed foods. They exhibit a complex chemistry in aqueous solution, which makes it difficult to study their chemistry under physiological conditions.
METHODS AND RESULTS:
Here we used a gel electrophoresis assay employing supercoiled DNA plasmid to examine the ability of these compounds (1) to intercalate DNA, (2) to inhibit human topoisomerase I through both inhibition of plasmid relaxation activity (catalytic inhibition) and stabilization of the cleavable DNA-topoisomerase complex (poisoning), and (3) to inhibit or enhance oxidative single-strand DNA nicking. We found no evidence of DNA intercalation by anthocyan(id)ins in the physiological pH range for any of the compounds used in this study-cyanidin chloride, cyanidin 3-O-glucoside, cyanidin 3,5-O-diglucoside, Malvidin-3-O-glucoside chloride and luteolinidin chloride. The anthocyanins inhibited topoisomerase relaxation activity only at high concentrations (> 50 muM) and we could find no evidence of topoisomerase I cleavable complex stabilization by these compounds.
CONCLUSIONS:
However, we observed that all of the anthocyan(id)ins used in this study were capable of inducing significant oxidative DNA strand cleavage (nicking) in the presence of 1 mM DTT (dithiothreitol), while the free radical scavenger, DMSO, at concentrations typically used in similar studies, completely inhibited DNA nicking. Finally, we propose a mechanism to explain the anthocyan(id)in induced oxidative DNA cleavage observed under our experimental conditions.

In vivo:

Nat Commun . 2018 Feb 2;9(1):477.

Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice[Pubmed: 29396460]

Abstract Major depressive disorder is associated with abnormalities in the brain and the immune system. Chronic stress in animals showed that epigenetic and inflammatory mechanisms play important roles in mediating resilience and susceptibility to depression. Here, through a high-throughput screening, we identify two phytochemicals, dihydrocaffeic acid (DHCA) and malvidin-3'-O-glucoside (Mal-gluc) that are effective in promoting resilience against stress by modulating brain synaptic plasticity and peripheral inflammation. DHCA/Mal-gluc also significantly reduces depression-like phenotypes in a mouse model of increased systemic inflammation induced by transplantation of hematopoietic progenitor cells from stress-susceptible mice. DHCA reduces pro-inflammatory interleukin 6 (IL-6) generations by inhibiting DNA methylation at the CpG-rich IL-6 sequences introns 1 and 3, while Mal-gluc modulates synaptic plasticity by increasing histone acetylation of the regulatory sequences of the Rac1 gene. Peripheral inflammation and synaptic maladaptation are in line with newly hypothesized clinical intervention targets for depression that are not addressed by currently available antidepressants.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
刺槐定氯化物; Robinetinidin chloride	CFN91856	3020-09-5	C₁₅H₁₁ClO₆ = 322.7	10mg	QQ客服：2159513211
氯化飞燕草素-3-O-葡萄糖苷; Delphinidin-3-O-glucoside chloride	CFN92038	6906-38-3	C₂₁H₂₁ClO₁₂ = 500.8	10mg	QQ客服：215959384
氯化飞燕草素-3-O-半乳糖苷; Delphinidin-3-O-galactoside chloride	CFN92037	28500-00-7	C₂₁H₂₁ClO₁₂ = 500.8	10mg	QQ客服：1413575084
氯化飞燕草素-3-O-桑布双糖苷; Delphinidin-3-sambubioside chloride	CFN92171	53158-73-9	C₂₆H₂₉O₁₆Cl = 633.0	5mg	QQ客服：2159513211
氯化飞燕草素-3-O-芸香糖苷; Delphinidin-3-O-rutinoside chloride	CFN92136	15674-58-5	C₂₇H₃₁O₁₆Cl = 645.0	5mg	QQ客服：1413575084
氯化飞燕草素-3,5-O-二葡萄糖苷; Delphinidin-3,5-O-diglucoside chloride	CFN92137	17670-06-3	C₂₇H₃₁O₁₇Cl = 663.0	5mg	QQ客服：1457312923
氯化飞燕草素-3-O-桑布双糖苷-5-O-葡萄糖苷; Delphinidin-3-O-sambubioside-5-O-glucoside chloride	CFN91870	36415-91-5	C₃₂H₃₉ClO₂₁ = 795.1	5mg	QQ客服：1413575084
氯化芍药素; Peonidin chloride	CFN92034	134-01-0	C₁₆H₁₃ClO₆ = 336.7	5mg	QQ客服：2056216494
氯化芍药素-3-O-阿拉伯糖苷; Peonidin-3-O-arabinoside chloride	CFN92047	524943-91-7	C₂₁H₂₁ClO₁₀ = 468.8	5mg	QQ客服：2159513211
氯化芍药素-3-O-半乳糖苷; Peonidin-3-O-galactoside chloride	CFN92045	28148-89-2	C₂₂H₂₃ClO₁₁ = 498.9	5mg	QQ客服：1457312923

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8907 mL	9.4536 mL	18.9072 mL	37.8143 mL	47.2679 mL
5 mM	0.3781 mL	1.8907 mL	3.7814 mL	7.5629 mL	9.4536 mL
10 mM	0.1891 mL	0.9454 mL	1.8907 mL	3.7814 mL	4.7268 mL
50 mM	0.0378 mL	0.1891 mL	0.3781 mL	0.7563 mL	0.9454 mL
100 mM	0.0189 mL	0.0945 mL	0.1891 mL	0.3781 mL	0.4727 mL

氯化锦葵色素-3-O-葡萄糖苷

Malvidin-3-O-glucoside chloride

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