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  • 羟基积雪草酸

    Madecassic acid

    羟基积雪草酸
    产品编号 CFN99914
    CAS编号 18449-41-7
    分子式 = 分子量 C30H48O6 = 504.70
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Centella asiatica (L.) Urban
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    羟基积雪草酸 CFN99914 18449-41-7 10mg QQ客服:2056216494
    羟基积雪草酸 CFN99914 18449-41-7 20mg QQ客服:2056216494
    羟基积雪草酸 CFN99914 18449-41-7 50mg QQ客服:2056216494
    羟基积雪草酸 CFN99914 18449-41-7 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Universiti Sains Malaysia (Malaysia)
  • Northeast Normal University Changchun (China)
  • Ain Shams University (Egypt)
  • University of Fribourg (Switzerland)
  • Mahidol University (Thailand)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Anna University (India)
  • University of Hawaii Cancer Center (USA)
  • University of Parma (Italy)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Sri Ramachandra University (India)
  • Universite Libre de Bruxelles (Belgium)
  • University of Cincinnati (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Agronomy2020, 10(10),1489
  • Institute of Food Science & Technology2021, 56(11).
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Tumour Biol.2015, 36(12):9385-93
  • Int J Med Sci.2021, 18(10):2155-2161.
  • J Chromatogr A.2022, 1685:463640.
  • Toxins (Basel).2021, 13(12):898.
  • Evid Based Complement Alternat Med.2020, 2020:2584783.
  • Sci Rep.2021, 11(1):10931.
  • Hum Exp Toxicol.2023, 42:9603271231171642.
  • J Cell Mol Med . 2023, jcmm.17954.
  • J Sci Food Agric.2018, 98(3):1153-1161
  • Plant Cell Tiss Org2017, 479-486
  • Pharmaceuticals (Basel).2022, 15(5):591.
  • J Int Med Res.2021, 49(7):3000605211032849.
  • Inflammation.2022, 45(6):2529-2543.
  • National University of Pharmacy2022, 1:73-76
  • Antioxidants (Basel).2022, 11(12):2327.
  • Molecules.2019, 24(23):E4303
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • Sci Rep. 2017, 8207(7)
  • Nutrients.2021, 13(8):2901.
  • ...
  • 生物活性
    Description: Madecassic acid has anti-diabetic, anti- tumor, wound-healing, and anti-inflammatory properties, it can improve glycemic control and hemostatic imbalance, lower lipid accumulation, and attenuate oxidative and inflammatory stress in diabetic mice. It can protect against hypoxia-induced oxidative stress in retinal microvascular endothelial cells via ROS-mediated endoplasmic reticulum stress. It inhibited the esspession of NOS, COX-2, TNF-alpha, IL-1beta, IL-6, and the downregulation of NF-kappaB activation.
    Targets: ROS | NOS | COX | TNF-α | IL Receptor | NF-kB | Caspase | Bcl-2/Bax | p65 | NO | PGE | gp120/CD4 | IkB | IKK
    In vitro:
    Biomed Pharmacother. 2016 Dec;84:845-852.
    Madecassic Acid protects against hypoxia-induced oxidative stress in retinal microvascular endothelial cells via ROS-mediated endoplasmic reticulum stress.[Pubmed: 27728894 ]
    Madecassic acid (MA) is an abundant triterpenoid in Centella asiatica (L.) Urban. (Apiaceae) that has been used as a wound-healing, anti-inflammatory and anti-cancer agent. Up to now, the effects of MA against oxidative stress remain unclear.
    METHODS AND RESULTS:
    In this study, we investigated the effect of MA and its mechanisms on hypoxia-induced human Retinal Microvascular Endothelial Cells (hRMECs). hRMECs were pre-treated with different concentrations of MA (0-50μM) for 30min before being incubated under hypoxia condition (37°C, 5% CO2 and 95% N2). Cell apoptosis was evaluated with MTT assay and TUNEL staining, and the expression of apoptosis- and endoplasmic reticulum (ER) stress-related molecules was assessed with western blotting and RT-PCR analysis. Intracellular ROS level was evaluated using DCFH-DA. Intracellular malondialdehyde (MDA), dehydrogenase (LDH), glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD) were evaluated using related Kits. Activating transcription factor 4 (ATF4) nuclear translocation was assessed with western blotting analysis and immunofluorescence staining. MA significantly reduced oxidative stress in hypoxia-induced hRMECs, as shown by increased cell viability, SOD and GSH-PX leakage, decreased TUNEL- and ROS-positive cell ratio, LDH and MDA leakage, caspase-3 and -9 activity, and Bax/Bcl-2 ratio. In addition, MA also attenuated hypoxia-induced ER stress in hRMECs, as shown by reduced mRNA levels of glucose-regulated protein 78 (GRP78), C/EBP homologous transcription factor (CHOP), protein levels of cleaved activating transcription factor 6 (ATF6) and inositol-requiring kinase/endonuclease 1 alpha (IRE1α), phosphorylation of pancreatic ER stress kinase (PERK) and eukaryotic initiation factor 2 alpha (eIF2α), cleaved caspase-12 and ATF4 translocation to nucleus.
    CONCLUSIONS:
    The current study indicated that the regulation of oxidative stress and ER stress by MA would be a promising therapy to reverse the process and development of hypoxia-induced hRMECs dysfunction.
    In vivo:
    Nutrients. 2015 Dec 2;7(12):10065-75.
    Anti-Diabetic Effects of Madecassic Acid and Rotundic Acid.[Pubmed: 26633490 ]
    Anti-diabetic effects of madecassic acid (MEA) and rotundic acid (RA) were examined.
    METHODS AND RESULTS:
    MEA or RA at 0.05% or 0.1% was supplied to diabetic mice for six weeks. The intake of MEA, not RA, dose-dependently lowered plasma glucose level and increased plasma insulin level. MEA, not RA, intake dose-dependently reduced plasminogen activator inhibitor-1 activity and fibrinogen level; as well as restored antithrombin-III and protein C activities in plasma of diabetic mice. MEA or RA intake decreased triglyceride and cholesterol levels in plasma and liver. Histological data agreed that MEA or RA intake lowered hepatic lipid droplets, determined by ORO stain. MEA intake dose-dependently declined reactive oxygen species (ROS) and oxidized glutathione levels, increased glutathione content and maintained the activity of glutathione reductase and catalase in the heart and kidneys of diabetic mice. MEA intake dose-dependently reduced interleukin (IL)-1β, IL-6, tumor necrosis factor-α and monocyte chemoattractant protein-1 levels in the heart and kidneys of diabetic mice. RA intake at 0.1% declined cardiac and renal levels of these inflammatory factors.
    CONCLUSIONS:
    These data indicated that MEA improved glycemic control and hemostatic imbalance, lowered lipid accumulation, and attenuated oxidative and inflammatory stress in diabetic mice. Thus, madecassic acid could be considered as an anti-diabetic agent.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9814 mL 9.9069 mL 19.8138 mL 39.6275 mL 49.5344 mL
    5 mM 0.3963 mL 1.9814 mL 3.9628 mL 7.9255 mL 9.9069 mL
    10 mM 0.1981 mL 0.9907 mL 1.9814 mL 3.9628 mL 4.9534 mL
    50 mM 0.0396 mL 0.1981 mL 0.3963 mL 0.7926 mL 0.9907 mL
    100 mM 0.0198 mL 0.0991 mL 0.1981 mL 0.3963 mL 0.4953 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去羟加利果酸; Esculentic acid CFN99059 103974-74-9 C30H48O5 = 488.7 5mg QQ客服:3257982914
    (2ALPHA,3BETA,4ALPHA)-2,3,23-三羟基乌苏-12,20(30)-二烯-28-酸; Actinidic acid CFN98444 341971-45-7 C30H46O5 = 486.7 5mg QQ客服:1413575084
    积雪草酸; Asiatic acid CFN98688 464-92-6 C30H48O5 = 488.7 20mg QQ客服:1413575084
    3-O-香豆酰积雪草酸; 3-O-Coumaroylasiatic acid CFN96830 143773-52-8 C39H54O7 = 634.85 5mg QQ客服:2159513211
    积雪草苷; Asiaticoside CFN99912 16830-15-2 C48H78O19 = 959.12 20mg QQ客服:2056216494
    羟基积雪草苷; Madecassoside CFN99913 34540-22-2 C48H78O20 = 975.13 20mg QQ客服:215959384
    积雪草苷B; Asiaticoside B CFN95124 125265-68-1 C48H78O20 = 975.13 20mg QQ客服:2056216494
    羟基积雪草酸; Madecassic acid CFN99914 18449-41-7 C30H48O6 = 504.70 20mg QQ客服:1457312923
    2,24-二羟基熊果酸; 2,24-Dihydroxyursolic acid CFN99481 143839-02-5 C30H48O5 = 488.7 5mg QQ客服:2159513211
    马尾柴酸; Barbinervic acid CFN96162 64199-78-6 C30H48O5 = 488.7 5mg QQ客服:215959384

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