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  • 桑橙素,2,3',4,4',6-五羟基二苯甲酮

    Maclurin

    桑橙素,2,3',4,4',6-五羟基二苯甲酮
    产品编号 CFN98836
    CAS编号 519-34-6
    分子式 = 分子量 C13H10O6 = 262.2
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Xanthones
    植物来源 The branches of Morus alba L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    桑橙素,2,3',4,4',6-五羟基二苯甲酮 CFN98836 519-34-6 1mg QQ客服:2056216494
    桑橙素,2,3',4,4',6-五羟基二苯甲酮 CFN98836 519-34-6 5mg QQ客服:2056216494
    桑橙素,2,3',4,4',6-五羟基二苯甲酮 CFN98836 519-34-6 10mg QQ客服:2056216494
    桑橙素,2,3',4,4',6-五羟基二苯甲酮 CFN98836 519-34-6 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Srinakharinwirot University (Thailand)
  • University of Hull (United Kingdom)
  • The Institute of Cancer Research (United Kingdom)
  • University of Sao Paulo (Brazil)
  • The Ohio State University (USA)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Ateneo de Manila University (Philippines)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Rio de Janeiro State University (Brazil)
  • University of Toulouse (France)
  • Universidad Miguel Hernández (Spain)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Chinese University of Hong Kong (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacol Rep.2018, 70(6):1195-1201
  • LWT2020, 110397
  • Int J Mol Sci.2022, 23(5):2796.
  • Phytomedicine.2018, 40:37-47
  • Phytother Res.2020, 34(4):788-795.
  • Indian J Pharm Sci.2022, 84(3):144-151
  • J Food Compos Anal2017, 62:197-204
  • Neuropharmacology.2018, 131:68-82
  • Int J Mol Sci.2018, 19(9):E2528
  • J Agric Food Chem.2022, 70(51):16176-16187.
  • VNU Journal of Science2023, 39(2):24-33.
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Int J Cosmet Sci.2023, 45(2):155-165.
  • Sci Rep.2018, 8:15059
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Bull. Pharm. Sci., Assiut University2020, 43(2):149-155.
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Sci Rep.2023, 13(1):14594.
  • Molecules.2019, 24(21):E3834
  • Int J Mol Sci.2020, 21(19):7209.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2022, 1203:123307.
  • Auburn University2015, 1-58
  • Food and Bioprocess Technology2017, 10(6):1074-1092
  • ...
  • 生物活性
    Description: Maclurin can effectively protect against mesenchymal stem cells (MSCs) oxidative damage induced by hydroxyl radical (OH) at 62.1-310.5 uM, the protective and antioxidant effects of maclurin can be primarily attributed to ortho-dihydroxyl groups, and ultimately to the relative stability of the ortho-benzoquinone form.Maclurin has anti-metastatic effect, the mechanism is by anti-oxidative activity and inhibition of Src/FAK-ERK-β-catenin signaling pathway.
    Targets: ROS | Src | FAK | ERK | Wnt/β-catenin | GSK-3 | MMP(e.g.TIMP)
    In vitro:
    Chem Biol Interact. 2014 Aug 5;219:221-8.
    Maclurin protects against hydroxyl radical-induced damages to mesenchymal stem cells: antioxidant evaluation and mechanistic insight.[Pubmed: 24973644]
    Maclurin, an exceptional member of phytophenol family, was found to effectively protect against mesenchymal stem cells (MSCs) oxidative damage induced by hydroxyl radical (OH) at 62.1-310.5 μM.
    METHODS AND RESULTS:
    Antioxidant assays indicated that Maclurin could efficiently protect DNA from OH-induced damage at 114.6-382.2 μM, and scavenge OH, DPPH (1,1-diphenyl-2-picrylhydrazyl radical), ABTS(+) (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid radical), and bind Cu(2+) (IC50 values were respectively 122.87 ± 10.14, 10.15 ± 0.85, 0.97 ± 0.07, and 133.95 ± 11.92 μM). HPLC-DAD and HPLC-ESI-MS/MS analyses of the end-product of Maclurin reaction with DPPH clearly suggested that Maclurin (m/z = 261.12 [M-H](-)) donated two hydrogen atoms to DPPH (m/z = 394.06 [M](+)) to form ortho-benzoquinone moiety (λmax = 364 nm; m/z = 259.06 [M-H](-), loss of m/z = 28) and DPPH2 molecule (m/z = 395.03, 396.01), via hydrogen atom transfer (HAT) or sequential electron (e) proton transfer (SEPT), not radical adduct formation (RAF) mechanisms.
    CONCLUSIONS:
    Therefore, we concluded that: (i) Maclurin can effectively protect against OH-induced damages to DNA and MSCs, thereby it may have a therapeutic potential in prevention of many diseases or MSCs transplantation; (ii) a possible mechanism for Maclurin to protect against oxidative damages is OH radical-scavenging; (iii) Maclurin scavenges OH possibly through metal-chelating, and direct radical-scavenging which is mainly via HAT or SEPT mechanisms; and (iv) the protective and antioxidant effects of Maclurin can be primarily attributed to ortho-dihydroxyl groups, and ultimately to the relative stability of the ortho-benzoquinone form.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8139 mL 19.0694 mL 38.1388 mL 76.2777 mL 95.3471 mL
    5 mM 0.7628 mL 3.8139 mL 7.6278 mL 15.2555 mL 19.0694 mL
    10 mM 0.3814 mL 1.9069 mL 3.8139 mL 7.6278 mL 9.5347 mL
    50 mM 0.0763 mL 0.3814 mL 0.7628 mL 1.5256 mL 1.9069 mL
    100 mM 0.0381 mL 0.1907 mL 0.3814 mL 0.7628 mL 0.9535 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2,6,4’-三羟基-4-甲氧基二苯甲酮; 2,6,4'-Trihydroxy-4-methoxybenzophenone CFN89307 55051-85-9 C14H12O5 = 260.24 10mg QQ客服:1457312923
    桑橙素,2,3',4,4',6-五羟基二苯甲酮; Maclurin CFN98836 519-34-6 C13H10O6 = 262.2 5mg QQ客服:1413575084
    鸢尾酚酮; Iriflophenone CFN98864 52591-10-3 C13H10O5 = 246.2 5mg QQ客服:2159513211
    二甲基穗罗汉松树脂酚; Dimethylmatairesinol CFN97524 943989-68-2 C19H20O9 = 392.4 5mg QQ客服:2159513211
    鸢尾酚酮3-C-beta-D-吡喃葡萄糖苷; Iriflophenone 3-C-beta-D-glucopyranoside CFN99063 104669-02-5 C19H20O10 = 408.4 5 mg QQ客服:2159513211
    硫赭曲菌素; Sulochrin CFN96651 519-57-3 C17H16O7 = 332.30 5mg QQ客服:2159513211
    Monomethylsulochrin ; Monomethylsulochrin CFN96952 10056-14-1 C18H18O7 = 346.33 5mg QQ客服:2056216494
    9-Dehydroxyeurotinone; 9-Dehydroxyeurotinone CFN89103 1360606-85-4 C15H12O5 = 272.25 5mg QQ客服:2159513211
    (2,3-二羟基苯基)(2-羟基-4,6-二甲氧基苯基)甲酮; 2,2',3'-Trihydroxy-4,6-dimethoxybenzophenone CFN98091 219861-73-1 C15H14O6 = 290.3 5mg QQ客服:215959384
    2,3',4,6-四羟基二苯甲酮; 2,3',4,6-Tetrahydroxybenzophenone CFN98302 26271-33-0 C13H10O5 = 246.2 5mg QQ客服:1413575084

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