马卡因; 高丽槐素

Maackiain

	产品编号	CFN99746
	CAS编号	19908-48-6
	分子式 = 分子量	C₁₆H₁₂O₅ = 284.27
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The flowers of Maackia amurensis Rupr.et Maxim.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
马卡因; 高丽槐素	CFN99746	19908-48-6	10mg	QQ客服：1413575084
马卡因; 高丽槐素	CFN99746	19908-48-6	20mg	QQ客服：1413575084
马卡因; 高丽槐素	CFN99746	19908-48-6	50mg	QQ客服：1413575084
马卡因; 高丽槐素	CFN99746	19908-48-6	100mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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doi: 10.1016/j.molcel.2017.10.022.
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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
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Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
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Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Bonn (Germany)

University of Melbourne (Australia)

National Research Council of Canada (Canada)

University of Perugia (Italy)

Semmelweis Unicersity (Hungary)

Instituto Politécnico de Bragan?a (Portugal)

Universidade Federal de Pernambuco (UFPE) (Brazil)

University of Liège (Belgium)

Universiti Putra Malaysia(UPM) (Malaysia)

University of Leipzig (Germany)

Chinese University of Hong Kong (China)

Guangzhou Institutes of Biomedicine and Health (China)

University of Dicle (Turkey)

Instytut Nawozów Sztucznych w Pu?awach (Poland)

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Description:

Maackiain is an antimicrobial compound (phytoalexins), it has anticancer effects, it induces apoptosis and growth suppression. Maackiain also shows strong larvicidal activity (LC50 = 21.95 ± 1.34 ug/mL).

Targets:

Antifection

In vitro:

Exp Parasitol. 2015 Jun;153:160-4.

Extract of Bowdichia virgilioides and maackiain as larvicidal agent against Aedes aegypti mosquito.[Pubmed: 25819294]

METHODS AND RESULTS:
The larvicidal activities of extracts of three hardwood species (Hymenaea stigonorcapa, Anadenanthera colubrina and Bowdichia virgilioides) against 4th instar larvae of Aedes aegypti were evaluated using WHO guidelines. Extracts of H. stignocarpa and A. colubrina showed weak activity. The highest larvicidal effect was obtained with the cyclohexane extract of the heartwood of B. virgilioides, which caused 100% mortality at concentrations at 50 and 100 µg/mL. Fraction toluene/EtOAc (8:2) from this extract showed larvicidal activity (LC₅₀ = 34.90 ± 1.27 µg/mL). A mixture of two compounds identified as medicarpin and maackiain exhibited a very good larvicidal activity (sub-fraction 2, LC₅₀ = 17.5 ± 1.87 µg/mL) and maackiain showed to be a strong larvicidal compound (LC₅₀ = 21.95 ± 1.34 µg/mL).
CONCLUSIONS:
This result can be of value in the search for new natural larvicidal compounds from other hardwood plant extracts and presents the first report of B. virgilioides being used to control a mosquito vector.

Oncol Rep. 2004 Dec;12(6):1183-8.

Induction of apoptosis by maackiain and trifolirhizin (maackiain glycoside) isolated from sanzukon (Sophora Subprostrate Chen et T. Chen) in human promyelotic leukemia HL-60 cells.[Pubmed: 15547735]

METHODS AND RESULTS:
We have investigated the effects of maackiain and trifolirhizin (maackiain glycoside) isolated from sanzukon (Sophora Subprostrate Chen et T. Chen) on DNA of human promyelotic HL-60 leukemia cells. It was found that extent of induction of apoptosis by maackiain was larger than that by trifolirhizin in human leukemia HL-60 cells. Morphological changes showing apoptotic bodies were observed in the HL-60 cells treated with maackiain and trifolirhizin. The fragmentations of DNA by maackiain and trifolirhizin to oligonucleosomal-sized fragments that is a characteristic of apoptosis was observed to be concentration- and time-dependent in the HL-60 cells.
CONCLUSIONS:
The data of the present study show that the suppressions by maackiain and trifolrhizin of growth of the HL-60 cells result from the induction of apoptosis by these compounds, and that the extent of growth suppression and induction of apoptosis by maackiain was greater than that by the glycoside (trifolirhizin).

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Sophoracarpan B ; Sophoracarpan B	CFN96671	1674359-84-2	C₁₇H₁₄O₆ = 314.30	5mg	QQ客服：1457312923
Meliotocarpan D; Meliotocarpan D	CFN95401	83013-81-4	C₁₇H₁₆O₆ = 316.3	5mg	QQ客服：1457312923
1,11B-二氢-11B-羟基美迪紫檀素; 1,11b-Dihydro-11b-hydroxymedicarpin	CFN96002	210537-04-5	C₁₆H₁₆O₅ = 288.3	5mg	QQ客服：1413575084
1,11B-二氢-11B-羟基高丽槐素; 1,11b-Dihydro-11b-hydroxymaackiain	CFN96003	210537-05-6	C₁₆H₁₄O₆ = 302.3	5mg	QQ客服：1413575084
Pterocarpadiol D; Pterocarpadiol D	CFN89484	2055882-23-8	C₁₆H₁₆O₆ = 304.29	5mg	QQ客服：1457312923
Pterocarpadiol C; Pterocarpadiol C	CFN89483	2055882-22-7	C₁₆H₁₄O₇ = 318.27	5mg	QQ客服：1413575084
Pterocarpadiol B; Pterocarpadiol B	CFN89481	2055882-20-5	C₁₆H₁₄O₆ = 302.27	5mg	QQ客服：3257982914
Pterocarpadiol A; Pterocarpadiol A	CFN89482	2055882-21-6	C₁₆H₁₂O₇ = 316.26	5mg	QQ客服：1413575084
巴西苏木素; 苏枋精; Brazilin	CFN98711	474-07-7	C₁₆H₁₄O₅ = 286.3	20mg	QQ客服：2056216494
苏木精; Hematoxylin	CFN96490	517-28-2	C₁₆H₁₄O₆ = 302.28	20mg	QQ客服：215959384

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5178 mL	17.5889 mL	35.1778 mL	70.3556 mL	87.9446 mL
5 mM	0.7036 mL	3.5178 mL	7.0356 mL	14.0711 mL	17.5889 mL
10 mM	0.3518 mL	1.7589 mL	3.5178 mL	7.0356 mL	8.7945 mL
50 mM	0.0704 mL	0.3518 mL	0.7036 mL	1.4071 mL	1.7589 mL
100 mM	0.0352 mL	0.1759 mL	0.3518 mL	0.7036 mL	0.8794 mL

马卡因; 高丽槐素

Maackiain

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