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    Lupeolic acid

    Lupeolic acid

    Lupeolic acid
    产品编号 CFN96255
    CAS编号 87355-32-6
    分子式 = 分子量 C30H48O3 = 456.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 From Boswellia carterii
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Lupeolic acid CFN96255 87355-32-6 1mg QQ客服:1413575084
    Lupeolic acid CFN96255 87355-32-6 5mg QQ客服:1413575084
    Lupeolic acid CFN96255 87355-32-6 10mg QQ客服:1413575084
    Lupeolic acid CFN96255 87355-32-6 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Beira Interior (Portugal)
  • University of Fribourg (Switzerland)
  • University of Leipzig (Germany)
  • Monash University (Australia)
  • University of British Columbia (Canada)
  • University of Illinois at Chicago (USA)
  • The Australian National University (Australia)
  • Chulalongkorn University (Thailand)
  • University of Hertfordshire (United Kingdom)
  • Uniwersytet Gdański (Poland)
  • China Medical University (Taiwan)
  • Rio de Janeiro State University (Brazil)
  • National Cancer Institute (USA)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Chem Biol Interact.2016, 260:168-175
  • Bulletin of Health Research2016, 44(4):279-286
  • J of L. Chroma.&Related Tech2017, 252-258
  • Sci Rep.2017, 7:467-479
  • Nat Prod Communications2018, 10.1177
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • Korean J Dent Mater.2018, 45(2):139-146
  • Journal of Life Science2018, 917-922
  • J of Essential Oil Research2019, 1677272
  • Molecules.2019, 24(4):E744
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Food Research International2020, 108987
  • Industrial Crops and Products2020, 146:112186
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Biotechnol Bioeng.2020, 117(7):2198-2208.
  • LWT2020, 130:109535
  • South African J of Botany2020, 135:50-57
  • Int J Biol Macromol.2020, 169:342-351
  • J Ethnopharmacol.2020, 254:112733.
  • Neurotox Res.2020, 38(1):163-174.
  • Natural Product Communications2020, doi: 10.1177.
  • Evid Based Complement Alternat Med.2021, 8707280.
  • ...
  • 生物活性
    Description: Lupeolic acid has anti-inflammatory activity.
    Targets: COX | PGE
    In vitro:
    J Nat Prod. 2014 Jun 27;77(6):1445-51.
    Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E(2) synthase-1.[Pubmed: 24844534 ]
    The microsomal prostaglandin E2 synthase (mPGES)-1 is the terminal enzyme in the biosynthesis of prostaglandin (PG)E2 from cyclooxygenase (COX)-derived PGH2. We previously found that mPGES-1 is inhibited by boswellic acids (IC50 = 3-30 μM), which are bioactive triterpene acids present in the anti-inflammatory remedy frankincense.
    METHODS AND RESULTS:
    Here we show that besides boswellic acids, additional known triterpene acids (i.e., tircuallic acid, Lupeolic acid, and roburic acid) isolated from frankincense suppress mPGES-1 with increased potencies. In particular, 3α-acetoxy-8,24-dienetirucallic acid (6) and 3α-acetoxy-7,24-dienetirucallic acid (10) inhibited mPGES-1 activity in a cell-free assay with IC50 = 0.4 μM, each. Structure-activity relationship studies and docking simulations revealed concrete structure-related interactions with mPGES-1 and its cosubstrate glutathione. COX-1 and -2 were hardly affected by the triterpene acids (IC50 > 10 μM).
    CONCLUSIONS:
    Given the crucial role of mPGES-1 in inflammation and the abundance of highly active triterpene acids in frankincence extracts, our findings provide further evidence of the anti-inflammatory potential of frankincense preparations and reveal novel, potent bioactivities of tirucallic acids, roburic acids, and Lupeolic acids.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1896 mL 10.9481 mL 21.8962 mL 43.7924 mL 54.7405 mL
    5 mM 0.4379 mL 2.1896 mL 4.3792 mL 8.7585 mL 10.9481 mL
    10 mM 0.219 mL 1.0948 mL 2.1896 mL 4.3792 mL 5.4741 mL
    50 mM 0.0438 mL 0.219 mL 0.4379 mL 0.8758 mL 1.0948 mL
    100 mM 0.0219 mL 0.1095 mL 0.219 mL 0.4379 mL 0.5474 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-表算盘子二醇; 3-Epiglochidiol CFN98360 29028-10-2 C30H50O2 = 442.7 5mg QQ客服:1457312923
    3-表算盘子二醇二乙酸酯; 3-Epiglochidiol diacetate CFN97122 6587-37-7 C34H54O4 = 526.8 5mg QQ客服:2932563308
    11β-羟基羽扇豆醇; 11beta-Hydroxylupeol CFN89288 49776-92-3 C30H50O2 = 442.72 5mg QQ客服:3257982914
    Adiantulupanone; Adiantulupanone CFN89066 51511-05-8 C29H48O = 412.70 5mg QQ客服:3257982914
    3beta-羟基-30-去甲羽扇烷; 29-Nor-20-oxolupeol CFN96388 19891-85-1 C29H48O2 = 428.7 5mg QQ客服:1457312923
    (3beta)-3-羟基羽扇-20(30)-烯-29-醛; 30-Oxolupeol CFN96383 64181-07-3 C30H48O2 = 440.7 5mg QQ客服:1457312923
    算盘子酮醇; Glochidonol CFN98248 23963-54-4 C30H48O2 = 440.7 5mg QQ客服:1413575084
    算盘子酮; Glochidone CFN97127 6610-55-5 C30H46O = 422.7 5mg QQ客服:2056216494
    羽扇烯酮; Lupenone CFN99681 1617-70-5 C30H48O = 424.7 10mg QQ客服:2932563308
    羽扇-20(29)-烯-3bate,23-二醇; Lup-20(29)-ene-3bate,23-diol CFN96184 163060-07-9 C30H50O2 = 442.7 5mg QQ客服:3257982914

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