| In vitro: |
| Molecules, 2014, 19(7):10650-10669. | | A Systematic Review of the Botanical, Phytochemical and Pharmacological Profile of Dracaena cochinchinensis, a Plant Source of the Ethnomedicine "Dragon's Blood".[Reference: WebLink] |
METHODS AND RESULTS:
"Dragon's blood" is the name given to a deep red resin obtained from a variety of plant sources. The resin extracted from stems of Dracaena cochinchinensis is one such source of "dragon's blood". It has a reputation for facilitating blood circulation and dispersing blood stasis. In traditional Chinese medicine, this resinous medicine is commonly prescribed to invigorate blood circulation for the treatment of traumatic injuries, blood stasis and pain. Modern pharmacological studies have found that this resinous medicine has anti-bacterial, anti-spasmodic, anti-inflammatory, analgesic, anti-diabetic, and anti-tumor activities, while it is also known to enhance immune function, promote skin repair, stop bleeding and enhance blood circulation. Various compounds have been isolated from the plant, including loureirin A, loureirin B, loureirin C, cochinchinenin, socotrin-4'-ol, 4',7-dihydroxyflavan, 4-methylcholest-7-ene-3-ol, ethylparaben, resveratrol, and hydroxyphenol.
CONCLUSIONS:
The present review summarizes current knowledge concerning the botany, phytochemistry, pharmacological effects, toxicology studies and clinical applications of this resinous medicine as derived from D. cochinchinenesis. | | Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology, 2015, 35(2):218-220. | | Virtual screening and activities in vitro of active components from total phenols part of dragon's blood on promoting blood circulation[Reference: WebLink] |
METHODS AND RESULTS:
Active components on promoting blood circulation and removing blood stasis were virtually screened by Discovery Studio with thrombin as receptor and the subjects were determined to be detected the effects on thrombin activities and anti-aggregation in vitro.Experimental data shows that the results of pharmacological effects correspond with that of the virtual screening.
CONCLUSIONS:
The subjects including loureirin A,loureirin B,loureirin C,7-hydroxy-4′-methoxy flavane,and 4′,7-dihydroxy-homoisoflavane can inhibit the activities of thrombin in vitro effectively. It is hypothesized that they play a crucial role in promoting blood circulation and removing blood stasis. |
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