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  • 马钱苷酸

    Loganic acid

    马钱苷酸
    产品编号 CFN98212
    CAS编号 22255-40-9
    分子式 = 分子量 C16H24O10 = 376.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Iridoids
    植物来源 The roots of Gentiana macrophylla Pall.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    马钱苷酸 CFN98212 22255-40-9 10mg QQ客服:2159513211
    马钱苷酸 CFN98212 22255-40-9 20mg QQ客服:2159513211
    马钱苷酸 CFN98212 22255-40-9 50mg QQ客服:2159513211
    马钱苷酸 CFN98212 22255-40-9 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Wollongong (Australia)
  • Deutsches Krebsforschungszentrum (Germany)
  • Universite Libre de Bruxelles (Belgium)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • National Cancer Institute (USA)
  • University of Oslo (Norway)
  • University of British Columbia (Canada)
  • Kitasato University (Japan)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Shanghai University of TCM (China)
  • Sapienza University of Rome (Italy)
  • Imperial College London (United Kingdom)
  • University of Amsterdam (Netherlands)
  • Wroclaw Medical University (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:242
  • Nat Prod Sci.2014, 20(3):182-190
  • Mol Med Rep.2015, 12(5):7789-95
  • Inflammation.2015, 38(4):1502-16
  • FEBS Lett.2015, 589(1):182-7
  • Braz J Med Biol Res. 2016, 49(7)
  • Eur J Pharm Sci.2016, 94:33-45
  • Molecules.2017, 22(11)
  • Pharmacol Rep.2017, 69(6):1224-1231
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • Nat Prod Commun.2018, 10.1177
  • Microchemical Journal2018, 137:168-173
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Biol Pharm Bull.2018, 41(11):1685-1693
  • Biochemistry.2018, 57(40):5886-5896
  • Pathogens.2018, 7(3):E62
  • Food Res Int.2019, 123:125-134
  • Neuropharmacology2019, 151437
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • FASEB J.2019, 33(2):2026-2036
  • Food Analytical Methods2020, 1-10
  • Nutrients2020, 12(2):488
  • Plant Growth Regulation2020, 90(2):383-392
  • ...
  • 生物活性
    Description: Loganic acid( 0.7% solution) has a strong intraocular pressure (IOP)-hypotensive effect, it exhibits both sides effect on superoxide generation. Loganic acid also has protective effects on atherosclerosis risk factors in hypercholesterolemic rabbits, it shows significant anti-inflammatory effects decreasing TNF-α and IL-6 activity in serum.
    Targets: PPAR | TNF-α | IL Receptor
    In vitro:
    Nat Prod Res. 2013;27(10):911-5.
    Anti-inflammatory effect of three iridoids in human neutrophils.[Pubmed: 22417122]
    To verify the anti-inflammatory potency of iridoids, three iridoids (two natural, loganic acid: LA; geniposide: GE; and an artefact, 7(S)-n-butyl morroniside: BM) were investigated in vitro on the inhibition of superoxide generation in human neutrophils.
    METHODS AND RESULTS:
    All compounds showed inhibitory effect on fMLP-induced superoxide generation in a concentration-dependent manner with the following order: BM>LA>GE. BM exhibits potent inhibitory activity on superoxide anion induced by PMA, while LA and GE showed weak effect. When AA was used as stimulus, the generation of superoxide anion was suppressed by BM in a concentration-dependent manner.
    CONCLUSIONS:
    LA and GE exhibit both sides effect on superoxide generation.
    In vivo:
    Phytomedicine. 2014 Nov 15;21(13):1774-84.
    The protective effect of the Cornus mas fruits (cornelian cherry) on hypertriglyceridemia and atherosclerosis through PPARα activation in hypercholesterolemic rabbits.[Pubmed: 25444446 ]
    Cornelian cherry (Cornus mas L.) fruits have been used in traditional cuisine and in folk medicine in various countries. This study was conducted to evaluate the constituents and impact of cornelian cherry (C. mas L.) fruits lyophilisate on lipid levels, PPARα protein expression, atheromatous changes in the aorta, oxido-redox state, and proinflammatory cytokines in hypercholesterolemic rabbits.
    METHODS AND RESULTS:
    The HPLC-MS method was used for determining active constituents in cornelian cherry. In a subsequent in vivo study the protective effect of the cornelian cherry on diet-induced hyperlipidemia was studied using a rabbit model fed 1% cholesterol. Cornelian cherry (100mg/kg b.w.) or simvastatin (5mg/kg b.w.) were administered orally for 60 days. Two iridoids - Loganic acid and cornuside - and five anthocyanins were identified as the main constituents of the cornelian cherry. The administering of the cornelian cherry led to a 44% significant decrease in serum triglyceride levels, as well as prevented development of atheromatous changes in the thoracic aorta. Cornelian cherry significantly increased PPARα protein expression in the liver, indicating that its hypolipidemic effect may stem from enhanced fatty acid catabolism. Simvastatin treatment did not affect PPAR-α expression. Moreover, the cornelian cherry had a significant protective effect on diet-induced oxidative stress in the liver, as well as restored upregulated proinflammatory cytokines serum levels.
    CONCLUSIONS:
    In conclusion, we have shown Loganic acid to be the main iridoid constituent in the European cultivar of the cornelian cherry, and proven that the cornelian cherry could have protective effects on diet-induced hypertriglicerydemia and atherosclerosis through enhanced PPARα protein expression and via regulating oxidative stress and inflammation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6567 mL 13.2837 mL 26.5675 mL 53.135 mL 66.4187 mL
    5 mM 0.5313 mL 2.6567 mL 5.3135 mL 10.627 mL 13.2837 mL
    10 mM 0.2657 mL 1.3284 mL 2.6567 mL 5.3135 mL 6.6419 mL
    50 mM 0.0531 mL 0.2657 mL 0.5313 mL 1.0627 mL 1.3284 mL
    100 mM 0.0266 mL 0.1328 mL 0.2657 mL 0.5313 mL 0.6642 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Adoxosidic acid; Adoxosidic acid CFN89313 84375-46-2 C16H24O10 = 376.35 5mg QQ客服:2159513211
    Suspenoidside B; Suspenoidside B CFN95071 2161432-08-0 C25H30O12 = 522.5 5mg QQ客服:2932563308
    京尼平苷酸; Geniposidic acid CFN98337 27741-01-1 C16H22O10 = 374.3 20mg QQ客服:2932563308
    鸡屎藤次苷; Scandoside CFN92535 18842-99-4 C16H22O11 = 390.3 5mg QQ客服:1413575084
    去乙酰基车叶草苷酸; Deacetylasperulosidic acid CFN92358 14259-55-3 C16H22O11 = 390.3 10mg QQ客服:1413575084
    车叶草苷酸; Asperulosidic acid CFN92108 25368-11-0 C18H24O12 = 432.4 10mg QQ客服:3257982914
    鸡屎藤苷酸; Paederosidic acid CFN92524 18842-98-3 C18H24O12S = 464.4 10mg QQ客服:215959384
    Euphroside; Euphroside CFN96341 76994-07-5 C16H24O10 = 376.4 5mg QQ客服:2159513211
    8-表去氧马钱子酸; 8-Epideoxyloganic acid CFN96280 88668-99-9 C16H24O9 = 360.4 5mg QQ客服:2159513211
    马钱苷酸; Loganic acid CFN98212 22255-40-9 C16H24O10 = 376.4 20mg QQ客服:3257982914

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