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  • 乌药环戊烯二酮

    Linderone

    乌药环戊烯二酮
    产品编号 CFN99837
    CAS编号 1782-79-2
    分子式 = 分子量 C16H14O5 = 286.3
    产品纯度 >=98%
    物理属性 Orange cryst.
    化合物类型 Chalcones
    植物来源 The roots of Lindera aggregata (Sims) Kosterm
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    乌药环戊烯二酮 CFN99837 1782-79-2 1mg QQ客服:2159513211
    乌药环戊烯二酮 CFN99837 1782-79-2 5mg QQ客服:2159513211
    乌药环戊烯二酮 CFN99837 1782-79-2 10mg QQ客服:2159513211
    乌药环戊烯二酮 CFN99837 1782-79-2 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universite Libre de Bruxelles (Belgium)
  • University of East Anglia (United Kingdom)
  • Mahidol University (Thailand)
  • Regional Crop Research Institute (Korea)
  • Universiti Sains Malaysia (Malaysia)
  • University of Hertfordshire (United Kingdom)
  • University of Melbourne (Australia)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • University of Ioannina (Greece)
  • University Medical Center Mainz (Germany)
  • University of Padjajaran (Indonesia)
  • Universite de Lille1 (France)
  • The Institute of Cancer Research (United Kingdom)
  • Medical University of South Carolina (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ginseng Res.2022, 46(1):104-114.
  • Scientific World Journal.2014, 2014:654193
  • Eur J Pharmacol.2022, 917:174744.
  • Life Sci.2023, 317:121458.
  • Phytother Res.2019, 33(3):676-689
  • Appl. Sci.2021, 11(19),9343.
  • J Pharm Biomed Anal.2018, 151:32-41
  • Int J Anal Chem.2017, 2017:1254721
  • J Biol Chem.2021, 297(6):101362.
  • Exp Neurobiol.2018, 27(3):200-209
  • Acta Edulis Fungi2020, 27(02):63-76.
  • Asian Pac J Tropical Bio.2020, 10(6):239-247
  • Int J Mol Sci.2018, 19(9):E2681
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • Molecules.2019, 24(22):E4022
  • Polytechnic University of Catalonia2017, 105826
  • Pharmacol Res.2020, 161:105205.
  • Int J Mol Sci.2019, 20(9):E2244
  • Analytical sci. & Tech2020, 33(5):224-231
  • Separations2021, 8(1), 1.
  • Pharmacogn J.2022, 14(2):350-357
  • LWT2020, 124:109163
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):21-39.
  • ...
  • 生物活性
    Description: Linderone A shows anticancer activity against A549 non-small cell lung cancer cells and PC-3 prostate adenocarcinoma cell line.
    In vitro:
    Comb Chem High Throughput Screen. 2013 Feb;16(2):160-6.
    Flavonoids and linderone from Lindera oxyphylla and their bioactivities.[Pubmed: 23173924]
    A new Linderone A, namely 2-cinnamoyl-3-hydroxy-4, 5-dimethoxycyclopenta-2, 4-dienone (5), together with three known flavonoids (1-3) and one Linderone (4), were isolated from the bark of Lindera oxyphylla.
    METHODS AND RESULTS:
    Extensive spectroscopic analysis including 1D and 2D-NMR spectra determined their sturctures. In addition, the antioxidant activity of all the compounds has been determined using 2, 2-diphenyl-1-picrylhydrazyl radical scavenging (DPPH), ferric reducing antioxidant power (FRAP) and ferrous ion chelating (FIC) methods. Compound 3 showed excellent DPPH scavenging activity with IC50% value of 8.5 ± 0.004% (μg/mL) which is comparable with vitamin C. This compound, also showed an absorbance value of 1.00 ± 0.06% through FRAP test when compared with Butyl Hydroxy Aniline (BHA). However, FIC showed low activity for all the isolated compounds (chelating activity less than 50%) in comparison with ethylene diamine tetra acetic acid (EDTA). Anticancer activity for all compounds has also been measured on A375 human melanoma, HT-29 colon adenocarcinoma, MCF-7 human breast adenocarcinoma cells, WRL-68 normal hepatic cells, A549 non-small cell lung cancer cells and PC-3 prostate adenocarcinoma cell line.
    CONCLUSIONS:
    Compound 1 showed A549=65.03%, PC-3=30.12%, MCF-7=47.67, compound 2 showed PC-3=90.13%, compound 3 showed MCF-7=79.57 and for compound 5 MCF-7 is 96.33.
    Org Lett. 2010 May 21;12(10):2354-7.
    Bi-linderone, a highly modified methyl-linderone dimer from Lindera aggregata with activity toward improvement of insulin sensitivity in vitro.[Pubmed: 20420414]
    Bi-Linderone (1) was isolated as racemate from the traditional Chinese medicinal plant Lindera aggregata.
    METHODS AND RESULTS:
    The structure elucidation of bi-Linderone was reported on the basis of extensive analysis of NMR spectra and crystal X-ray diffraction. Bi-Linderone has an unprecedented spirocyclopentenedione-containing carbon skeleton and showed significant activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 microg/mL.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4928 mL 17.4642 mL 34.9284 mL 69.8568 mL 87.321 mL
    5 mM 0.6986 mL 3.4928 mL 6.9857 mL 13.9714 mL 17.4642 mL
    10 mM 0.3493 mL 1.7464 mL 3.4928 mL 6.9857 mL 8.7321 mL
    50 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.3971 mL 1.7464 mL
    100 mM 0.0349 mL 0.1746 mL 0.3493 mL 0.6986 mL 0.8732 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    赤芝酮; Lucidone CFN98011 19956-53-7 C15H12O4 = 256.3 5mg QQ客服:2159513211
    甲基赤芝萜酮; Methyllucidone CFN98012 19956-54-8 C16H14O4 = 270.3 5mg QQ客服:215959384
    乙基赤芝酮; Ethyllucidone CFN99308 1195233-59-0 C17H16O4 = 284.3 5mg QQ客服:1457312923
    乌药环戊烯二酮; Linderone CFN99837 1782-79-2 C16H14O5 = 286.3 5mg QQ客服:1413575084
    乌药环戊烯二酮甲醚; Methyllinderone CFN98631 3984-73-4 C17H16O5 = 300.3 5mg QQ客服:215959384

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